Protein Dossier — PPID (Peptidyl-prolyl cis-trans isomerase D)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Ischemic stroke |
-0.123 |
0.0357 |
5.91e-04 |
Wald ratio |
1 |
cis |
NA |
| Pulse rate |
0.0316 |
0.0092 |
5.93e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) |
-0.101 |
0.0409 |
0.0138 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt |
-0.164 |
0.0683 |
0.0165 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: iron deficiency anaemia |
0.146 |
0.0619 |
0.0183 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
0.00966 |
0.00427 |
0.0237 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: retinal detachment |
0.17 |
0.077 |
0.0276 |
Wald ratio |
1 |
cis |
NA |
| Serum cystatin C (eGFRcys) |
-0.00878 |
0.00399 |
0.0278 |
Wald ratio |
1 |
cis |
NA |
| Age at menarche |
0.0259 |
0.0124 |
0.037 |
Wald ratio |
1 |
cis |
NA |
| Inflammatory bowel disease |
-0.0468 |
0.0226 |
0.0386 |
Wald ratio |
1 |
cis |
NA |
| Amyotrophic lateral sclerosis |
-0.079 |
0.0387 |
0.0412 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: C61 Malignant neoplasm of prostate |
-0.152 |
0.0749 |
0.0417 |
Wald ratio |
1 |
cis |
NA |
| …and 107 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5202_4_3 |
PPID |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
50 association rows across 35 traits (48 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Peptidyl-prolyl cis-trans isomerase D levels |
2e-276 |
rs17843929 |
5 |
GCST90249093 |
no MR -> candidate analysis |
| Decanoylcarnitine levels |
2e-118 |
rs8396 |
3 |
GCST90010763 |
no MR -> candidate analysis |
| Octanoylcarnitine levels |
2e-113 |
rs8396 |
4 |
GCST90010761 |
no MR -> candidate analysis |
| Cerebrospinal fluid glutarylcarnitine (C5-DC) levels |
6e-64 |
rs9410 |
1 |
GCST90318011 |
no MR -> candidate analysis |
| Octanoylcarnitine (C8) levels |
7e-37 |
rs17843929 |
2 |
GCST90139734 |
no MR -> candidate analysis |
| Dodecanoylcarnitine levels |
1e-35 |
rs2070630 |
2 |
GCST90010765 |
no MR -> candidate analysis |
| Decanoylcarnitine (C10) levels |
5e-35 |
rs17843929 |
1 |
GCST90139736 |
no MR -> candidate analysis |
| Nonanoylcarnitine (C9) levels |
4e-28 |
rs17843929 |
1 |
GCST90139937 |
no MR -> candidate analysis |
| Metabolite levels |
4e-24 |
rs8396 |
1 |
GCST000550 |
no MR -> candidate analysis |
| Decenoylcarnitine levels |
7e-22 |
rs8396 |
2 |
GCST90010764 |
no MR -> candidate analysis |
| Cis-4-decenoyl carnitine levels |
2e-20 |
rs55936281 |
2 |
GCST90102911 |
no MR -> candidate analysis |
| Blood 3-decenoylcarnitine levels |
3e-20 |
rs9410 |
1 |
GCST90840642 |
no MR -> candidate analysis |
| …and 23 more traits (see JSON) |
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|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 97 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| frozen shoulder |
0.419 |
— |
common-variant locus |
no MR -> candidate analysis |
| gallbladder disorder |
0.419 |
— |
common-variant locus |
no MR -> candidate analysis |
| health study participation |
0.094 |
— |
common-variant locus |
no MR -> candidate analysis |
| Abnormality of the skeletal system |
0.085 |
— |
common-variant locus |
no MR -> candidate analysis |
| smoking cessation |
0.076 |
— |
common-variant locus |
no MR -> candidate analysis |
| hypotensive disorder |
0.057 |
— |
common-variant locus |
no MR -> candidate analysis |
| major depressive disorder |
0.053 |
— |
common-variant locus |
no MR -> candidate analysis |
| insomnia |
0.052 |
— |
common-variant locus |
no MR -> candidate analysis |
| intelligence |
0.039 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 9 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Peptidyl-prolyl cis-trans isomerase D) |
| gnomAD constraint |
pLI=3.5e-16, LOEUF=1.25 — LoF-tolerant |
| GWAS Catalog |
31 unique SNPs / 62 rows |
| ClinVar |
114 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 97 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘PPID’ and resolved to ‘Peptidyl-prolyl cis-trans isomerase D’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 114 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 35 traits by best p-value, aggregated from 50 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q08752 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000171497/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1697657/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/PPID — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PPID — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PPID%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PPID — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:33:57 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none