MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Systolic blood pressure automated reading | -0.0317 | 0.00938 | 7.33e-04 | Wald ratio | 1 | trans | NA |
| Forearm bone mineral density | -0.2 | 0.06 | 8.48e-04 | Wald ratio | 1 | trans | NA |
| Forced vital capacity (FVC) | 0.0223 | 0.00752 | 0.00298 | Wald ratio | 1 | trans | NA |
| Mean cell haemoglobin concentration | -0.0308 | 0.013 | 0.0177 | Wald ratio | 1 | trans | NA |
| Eye problems or disorders: Glaucoma | 0.147 | 0.0664 | 0.0271 | Wald ratio | 1 | trans | NA |
| Diastolic blood pressure automated reading | -0.0206 | 0.00939 | 0.0283 | Wald ratio | 1 | trans | NA |
| Clear cell ovarian cancer | -0.334 | 0.153 | 0.0286 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter | 0.195 | 0.0907 | 0.0317 | Wald ratio | 1 | trans | NA |
| Bulimia nervosa | -0.0557 | 0.026 | 0.0321 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis | -0.0808 | 0.0409 | 0.0486 | Wald ratio | 1 | trans | NA |
| Sodium in urine | -0.0172 | 0.00902 | 0.0568 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: C50 Malignant neoplasm of breast | -0.154 | 0.0843 | 0.0675 | Wald ratio | 1 | trans | NA |
| …and 91 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
148 association rows across 127 traits (134 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Height | 1e-300 | rs13079205 | 2 | GCST90245843 | no MR -> candidate analysis |
| Cholesterol to Total Lipids in Very Large HDL percentage | 2e-41 | rs34330586 | 1 | GCST90501295 | no MR -> candidate analysis |
| Estimated glomerular filtration rate (creatinine, cystatin c | 2e-39 | rs10512987 | 1 | GCST90428446 | no MR -> candidate analysis |
| Estimated glomerular filtration rate (cystatin c) | 7e-39 | rs10512987 | 1 | GCST90428448 | no MR -> candidate analysis |
| PTPRS protein levels | 4e-30 | rs4431046 | 1 | GCST90470387 | no MR -> candidate analysis |
| Urea levels (UKB data field 30670) | 1e-29 | rs13079205 | 1 | GCST90468108 | no MR -> candidate analysis |
| Circulating PTPRS levels | 6e-29 | rs4431046 | 1 | GCST90860481 | no MR -> candidate analysis |
| Estimated glomerular filtration rate based on creatinine and | 1e-28 | rs10512987 | 1 | GCST90566737 | no MR -> candidate analysis |
| Fibrinogen levels or factor VII levels (pleiotropy) | 2e-28 | rs150213942 | 1 | GCST90129557 | no MR -> candidate analysis |
| Ischemic stroke or fibrinogen levels (pleiotropy) | 5e-28 | rs150213942 | 1 | GCST90129553 | no MR -> candidate analysis |
| Fibrinogen levels | 2e-27 | rs9840812 | 2 | GCST003194 | no MR -> candidate analysis |
| Blood urea nitrogen levels | 4e-27 | rs6793835 | 1 | GCST90018948 | no MR -> candidate analysis |
| …and 115 more traits (see JSON) |
Top diseases by Open Targets association (of 139 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| diabetes mellitus | 0.654 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.618 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.501 | — | common-variant locus | no MR -> candidate analysis |
| type 1 diabetes mellitus | 0.474 | — | common-variant locus | no MR -> candidate analysis |
| aortic stenosis | 0.463 | — | common-variant locus | no MR -> candidate analysis |
| dyslexia | 0.455 | — | common-variant locus | no MR -> candidate analysis |
| heart failure | 0.427 | — | common-variant locus | no MR -> candidate analysis |
| atrial fibrillation | 0.433 | — | common-variant locus | no MR -> candidate analysis |
| secondary malignant neoplasm | 0.428 | — | common-variant locus | no MR -> candidate analysis |
| myocardial ischemia | 0.418 | — | common-variant locus | no MR -> candidate analysis |
| Cachexia | 0.406 | — | common-variant locus | no MR -> candidate analysis |
| ulcerative colitis | 0.398 | — | common-variant locus | no MR -> candidate analysis |
| placental retention | 0.403 | — | common-variant locus | no MR -> candidate analysis |
| Increased total eosinophil count | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| chronic kidney disease | 0.396 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1.8e-20, LOEUF=0.901 — LoF-tolerant |
| GWAS Catalog | 103 unique SNPs / 228 rows |
| ClinVar | 243 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 139 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘PPP2R3A’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 243 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 127 traits by best p-value, aggregated from 148 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q06190 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000073711/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/PPP2R3A — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PPP2R3A — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PPP2R3A%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PPP2R3A — GWAS Catalog search API (live; release not exposed)