MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: muscle or soft tissue injuries | 0.365 | 0.0893 | 4.37e-05 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: kidney stone or ureter stone or bladder stone | 0.294 | 0.0917 | 0.00134 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms | 0.198 | 0.0724 | 0.00616 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: ankylosing spondylitis | 0.385 | 0.142 | 0.00685 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R14 Flatulence and related conditions | 0.646 | 0.254 | 0.0109 | Wald ratio | 1 | cis | NA |
| Bulimia nervosa | -0.0859 | 0.0344 | 0.0124 | Wald ratio | 1 | cis | NA |
| Coronary heart disease | 0.108 | 0.0445 | 0.0153 | Wald ratio | 1 | cis | NA |
| Myocardial infarction | 0.117 | 0.0489 | 0.017 | Wald ratio | 1 | cis | NA |
| Amyotrophic lateral sclerosis | 0.191 | 0.0811 | 0.0183 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level | 0.391 | 0.191 | 0.0404 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: bone disorder | 0.328 | 0.172 | 0.0561 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis | 0.235 | 0.127 | 0.0644 | Wald ratio | 1 | cis | NA |
| …and 52 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
15 association rows across 12 traits (12 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating PRCP levels | 4e-112 | rs530515812 | 3 | GCST90860469 | no MR -> candidate analysis |
| Lysosomal Pro-X carboxypeptidase levels | 5e-67 | rs2229437 | 1 | GCST90248367 | no MR -> candidate analysis |
| Adolescent idiopathic scoliosis | 7e-33 | rs12289095 | 1 | GCST006287 | no MR -> candidate analysis |
| PRCP protein levels | 1e-28 | rs2510290 | 2 | GCST90470314 | no MR -> candidate analysis |
| Lysosomal Pro-X carboxypeptidase levels (PRCP.5722.78.3) | 3e-20 | rs2229437 | 1 | GCST90241844 | no MR -> candidate analysis |
| Serum levels of protein PRCP | 4e-16 | rs2229437 | 1 | GCST90089168 | no MR -> candidate analysis |
| PCP protein level (protein group normalized intensity) | 6e-12 | rs11233371 | 1 | GCST90570869 | no MR -> candidate analysis |
| Blood protein levels | 2e-9 | rs10898041 | 1 | GCST006585 | no MR -> candidate analysis |
| COVID-19 (hospitalized covid vs population) | 2e-8 | rs77599934 | 1 | GCST90454506 | no MR -> candidate analysis |
| RS-10-hydroxywarfarin to RS-warfarin ratio | 9e-7 | rs142660981 | 1 | GCST90129574 | no MR -> candidate analysis |
| Tinnitus | 5e-6 | rs7107322 | 1 | GCST90267564 | no MR -> candidate analysis |
| Obesity-related traits | 6e-6 | rs10792665 | 1 | GCST001762 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 167 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| stroke disorder | 0.401 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.401 | — | common-variant locus | no MR -> candidate analysis |
| adolescent idiopathic scoliosis | 0.391 | — | common-variant locus | no MR -> candidate analysis |
| herpes zoster | 0.092 | — | common-variant locus | no MR -> candidate analysis |
| psoriatic arthritis | 0.071 | — | common-variant locus | no MR -> candidate analysis |
Of the 5 rows above, 5 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Lysosomal Pro-X carboxypeptidase) |
| gnomAD constraint | pLI=6.9e-14, LOEUF=1.09 — LoF-tolerant |
| GWAS Catalog | 23 unique SNPs / 42 rows |
| ClinVar | 105 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | 1 clinical annotations across 1 drugs |
phenome — Top 30 of 167 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘PRCP’ and resolved to ‘Lysosomal Pro-X carboxypeptidase’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 105 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 12 of 12 traits by best p-value, aggregated from 15 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P42785 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000137509/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2335/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/PRCP — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PRCP — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PRCP%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=PRCP — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/PRCP — GWAS Catalog search API (live; release not exposed)