Protein Dossier — PRDX6 (Peroxiredoxin-6)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Forced vital capacity (FVC) |
0.0215 |
0.00612 |
4.51e-04 |
Wald ratio |
1 |
cis |
NA |
| Forced expiratory volume in 1-second (FEV1) |
0.0206 |
0.00646 |
0.00142 |
Wald ratio |
1 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
-0.0303 |
0.00966 |
0.00171 |
Wald ratio |
1 |
cis |
NA |
| Birth weight |
0.0305 |
0.0111 |
0.00616 |
Wald ratio |
1 |
cis |
NA |
| Alcohol intake frequency |
-0.0301 |
0.011 |
0.0063 |
Wald ratio |
1 |
cis |
NA |
| Rheumatoid arthritis |
-0.095 |
0.0356 |
0.00772 |
Wald ratio |
1 |
cis |
NA |
| Schizophrenia |
-0.0857 |
0.0327 |
0.00874 |
Wald ratio |
1 |
cis |
NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
0.0484 |
0.0196 |
0.0135 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux |
0.0808 |
0.0332 |
0.015 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: migraine |
-0.116 |
0.0485 |
0.0172 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
-0.0139 |
0.00583 |
0.0174 |
Wald ratio |
1 |
cis |
NA |
| Body fat |
0.4 |
0.169 |
0.018 |
Wald ratio |
1 |
cis |
NA |
| …and 104 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5018_68_1 |
Peroxiredoxin-6 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
19 association rows across 16 traits (14 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| CASP8/PRDX6 protein level ratio |
5e-102 |
rs7549074 |
1 |
GCST90313655 |
no MR -> candidate analysis |
| PRDX6 protein levels |
1e-95 |
rs7529089 |
2 |
GCST90470319 |
no MR -> candidate analysis |
| Serum levels of protein PRDX6 |
9e-53 |
rs34259759 |
1 |
GCST90088875 |
no MR -> candidate analysis |
| Blood protein levels |
9e-33 |
rs6671141 |
1 |
GCST006585 |
no MR -> candidate analysis |
| TNN protein levels |
2e-22 |
rs569204712 |
2 |
GCST90470927 |
no MR -> candidate analysis |
| Circulating PRDX6 levels |
4e-22 |
rs35263596 |
1 |
GCST90860534 |
no MR -> candidate analysis |
| Ease of getting up in the morning |
1e-11 |
rs148137538 |
1 |
GCST007986 |
no MR -> candidate analysis |
| Body mass index |
2e-9 |
rs148137538 |
2 |
GCST009871 |
no MR -> candidate analysis |
| Non-alcoholic fatty liver disease or type 2 diabetes |
5e-9 |
rs61828878 |
1 |
GCST90272881 |
no MR -> candidate analysis |
| Morningness |
6e-9 |
rs148137538 |
1 |
GCST007983 |
no MR -> candidate analysis |
| Adult body size |
4e-8 |
rs148137538 |
1 |
GCST010988 |
no MR -> candidate analysis |
| Phosphate levels |
8e-8 |
rs571961047 |
1 |
GCST90245374 |
no MR -> candidate analysis |
| …and 4 more traits (see JSON) |
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|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 657 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| hypothyroidism |
0.543 |
— |
common-variant locus |
MR: beta=-0.0479, p=0.169 (cis) |
| systemic lupus erythematosus |
0.469 |
— |
common-variant locus |
MR: beta=-0.134, p=0.362 (cis) |
| rheumatoid arthritis |
0.468 |
— |
common-variant locus |
MR: beta=-0.095, p=0.00772 (cis) |
| placental retention |
0.382 |
— |
common-variant locus |
no MR -> candidate analysis |
| systemic sclerosis |
0.338 |
— |
common-variant locus |
no MR -> candidate analysis |
| COVID-19 |
0.329 |
— |
common-variant locus |
no MR -> candidate analysis |
| tricuspid valve disorder |
0.32 |
— |
common-variant locus |
no MR -> candidate analysis |
| type 2 diabetes mellitus |
0.197 |
— |
common-variant locus |
no MR -> candidate analysis |
| metabolic dysfunction-associated steatotic liver disease |
0.197 |
— |
common-variant locus |
no MR -> candidate analysis |
| Abnormality of the skeletal system |
0.18 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 10 rows above, 7 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Peroxiredoxin-6) |
| gnomAD constraint |
pLI=0.0013, LOEUF=1.03 — LoF-tolerant |
| GWAS Catalog |
37 unique SNPs / 73 rows |
| ClinVar |
71 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 657 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘PRDX6’ and resolved to ‘Peroxiredoxin-6’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 71 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 16 of 16 traits by best p-value, aggregated from 19 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P30041 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000117592/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4295741/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/PRDX6 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PRDX6 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PRDX6%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PRDX6 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:36:12 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none