MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Cardioembolic stroke | 0.265 | 0.0916 | 0.0038 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: anxiety or panic attacks | -0.228 | 0.0802 | 0.0045 | Wald ratio | 1 | cis | NA |
| Ovarian cancer | -0.108 | 0.0405 | 0.00744 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: sleep apnoea | 0.264 | 0.103 | 0.0104 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis | 0.219 | 0.0872 | 0.0121 | Wald ratio | 1 | cis | NA |
| Height | -0.0221 | 0.00905 | 0.0147 | Wald ratio | 1 | cis | NA |
| Lung adenocarcinoma | -0.175 | 0.0745 | 0.019 | Wald ratio | 1 | cis | NA |
| High grade serous ovarian cancer | -0.11 | 0.048 | 0.0217 | Wald ratio | 1 | cis | NA |
| Sodium in urine | 0.0156 | 0.00724 | 0.0313 | Wald ratio | 1 | cis | NA |
| Hip osteoarthritis | 0.184 | 0.0859 | 0.0321 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: vitiligo | 0.577 | 0.273 | 0.0344 | Wald ratio | 1 | cis | NA |
| Anorexia nervosa | 0.17 | 0.0815 | 0.0367 | Wald ratio | 1 | cis | NA |
| …and 97 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
75 association rows across 51 traits (57 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Serum levels of protein PREP | 1e-65 | rs1051484 | 2 | GCST90087854 | no MR -> candidate analysis |
| Blood protein levels | 7e-44 | rs1051484 | 1 | GCST006585 | no MR -> candidate analysis |
| Male-pattern baldness | 6e-40 | rs10457129 | 4 | GCST007020 | no MR -> candidate analysis |
| Prolyl endopeptidase level in Chronic kidney disease with hy | 3e-36 | rs1051484 | 1 | GCST90234249 | no MR -> candidate analysis |
| Prolyl endopeptidase levels | 2e-30 | rs71748560 | 2 | GCST90249088 | no MR -> candidate analysis |
| Balding type 1 | 2e-27 | rs17804660 | 1 | GCST007038 | no MR -> candidate analysis |
| JT interval | 6e-25 | rs2634854 | 1 | GCST90179157 | no MR -> candidate analysis |
| heart rate (HR, mean, inv-normal transformed) | 4e-22 | rs117979970 | 1 | GCST90480666 | no MR -> candidate analysis |
| Cough in response to angiotensin-converting enzyme inhibitor | 4e-21 | rs7761208 | 1 | GCST90573176 | no MR -> candidate analysis |
| Chronic dry cough or cough in response to angiotensin-conver | 2e-20 | rs7761208 | 1 | GCST90573177 | no MR -> candidate analysis |
| BCHE protein levels | 9e-20 | rs72939784 | 2 | GCST90468429 | no MR -> candidate analysis |
| ACE-inhibitor discontinuation | 1e-19 | rs12210271 | 1 | GCST90132618 | no MR -> candidate analysis |
| …and 39 more traits (see JSON) |
Top diseases by Open Targets association (of 269 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| response to angiotensin-converting enzyme inhibitor | 0.691 | — | common-variant locus | no MR -> candidate analysis |
| Cough | 0.641 | — | common-variant locus | no MR -> candidate analysis |
| androgenetic alopecia | 0.619 | — | common-variant locus | no MR -> candidate analysis |
| Peptic ulcer | 0.488 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.474 | — | common-variant locus | no MR -> candidate analysis |
| atrial fibrillation | 0.449 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.448 | — | common-variant locus | no MR -> candidate analysis |
| preeclampsia | 0.446 | — | common-variant locus | no MR -> candidate analysis |
| connective tissue disorder | 0.428 | — | common-variant locus | no MR -> candidate analysis |
| alopecia | 0.426 | — | common-variant locus | no MR -> candidate analysis |
| polycythemia | 0.419 | — | common-variant locus | no MR -> candidate analysis |
| colorectal cancer | 0.4 | — | common-variant locus | no MR -> candidate analysis |
| Peyronie disease | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| tooth eruption | 0.361 | — | common-variant locus | no MR -> candidate analysis |
| facial morphology | 0.359 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Prolyl endopeptidase) |
| gnomAD constraint | pLI=1, LOEUF=0.451 — LoF-INTOLERANT |
| GWAS Catalog | 58 unique SNPs / 95 rows |
| ClinVar | 118 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 269 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘PREP’ and resolved to ‘Prolyl endopeptidase’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 118 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 51 traits by best p-value, aggregated from 75 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P48147 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000085377/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3202/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/PREP — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PREP — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PREP%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PREP — GWAS Catalog search API (live; release not exposed)