MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: I30 Acute pericarditis | 0.356 | 0.129 | 0.00593 | Wald ratio | 1 | cis | NA |
| HOMA-B | 0.00999 | 0.0041 | 0.0147 | Wald ratio | 1 | cis | NA |
| Systolic blood pressure automated reading | 0.00784 | 0.00325 | 0.016 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoporosis | 0.0574 | 0.0241 | 0.017 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | 0.0076 | 0.00325 | 0.0195 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: asthma | 0.0197 | 0.00872 | 0.0236 | Wald ratio | 1 | cis | NA |
| Packed cell volume | 0.0514 | 0.0232 | 0.0264 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: iron deficiency anaemia | 0.0885 | 0.0399 | 0.0265 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M23 Internal derangement of knee | 0.0451 | 0.0204 | 0.0271 | Wald ratio | 1 | cis | NA |
| Lung adenocarcinoma | 0.0833 | 0.039 | 0.0326 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N81 Female genital prolapse | 0.0535 | 0.0252 | 0.0336 | Wald ratio | 1 | cis | NA |
| Pulse rate | 0.0115 | 0.00562 | 0.0415 | Wald ratio | 1 | cis | NA |
| …and 97 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
22 association rows across 19 traits (19 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Prokineticin-2 levels | 6e-1260 | rs7644362 | 2 | GCST90249111 | no MR -> candidate analysis |
| Blood protein levels | 3e-289 | rs7644362 | 1 | GCST006585 | no MR -> candidate analysis |
| Serum levels of protein PROK2 | 2e-97 | rs6777956 | 1 | GCST90086438 | no MR -> candidate analysis |
| Prokineticin-2 level in Chronic kidney disease with hyperten | 6e-46 | rs7644362 | 1 | GCST90232979 | no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) | 9e-25 | rs7644362 | 1 | GCST90838669 | no MR -> candidate analysis |
| Smoking initiation | 3e-13 | rs116516927 | 2 | GCST90243985 | no MR -> candidate analysis |
| Monocyte percentage of white cells | 6e-12 | rs7634474 | 1 | GCST90002394 | no MR -> candidate analysis |
| Albumin levels | 2e-11 | rs2654439 | 1 | GCST90501097 | no MR -> candidate analysis |
| Monocyte count | 5e-11 | rs3796224 | 2 | GCST90002344 | no MR -> candidate analysis |
| Frailty (General Factor) | 7e-11 | rs116310555 | 1 | GCST90624046 | no MR -> candidate analysis |
| Depression | 9e-9 | rs116310555 | 1 | GCST90319327 | MR: beta=0.0469, p=0.431 (cis) |
| Neuroticism conditioned on self-rated math ability (multi-tr | 1e-8 | rs116310555 | 1 | GCST90027244 | no MR -> candidate analysis |
| …and 7 more traits (see JSON) |
Top diseases by Open Targets association (of 299 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| hypogonadotropic hypogonadism | 0.807 | — | established (curated) | no MR -> candidate analysis |
| hypogonadotropic hypogonadism 4 with or without anosmia | 0.875 | — | established (curated) | no MR -> candidate analysis |
| Kallmann syndrome | 0.608 | — | established (curated) | no MR -> candidate analysis |
| hereditary disease | 0.736 | — | established (curated) | no MR -> candidate analysis |
| male infertility with azoospermia or oligozoospermia due to single gene mutation | 0.559 | — | established (curated) | no MR -> candidate analysis |
| Male infertility with spermatogenesis disorder | 0.547 | — | established (curated) | no MR -> candidate analysis |
| Alzheimer disease | 0.449 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.443 | — | common-variant locus | no MR -> candidate analysis |
| malignant renal pelvis neoplasm | 0.364 | — | common-variant locus | no MR -> candidate analysis |
| dermatophytosis | 0.35 | — | common-variant locus | no MR -> candidate analysis |
| vertebral joint disorder | 0.347 | — | common-variant locus | no MR -> candidate analysis |
| anaphylaxis | 0.336 | — | common-variant locus | no MR -> candidate analysis |
| scoliosis | 0.336 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.329 | — | common-variant locus | no MR -> candidate analysis |
| atrial fibrillation | 0.306 | — | common-variant locus | MR: beta=0.0238, p=0.418 (cis) |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Prokineticin-2) |
| gnomAD constraint | pLI=0.03, LOEUF=1.02 — LoF-tolerant |
| GWAS Catalog | 31 unique SNPs / 62 rows |
| ClinVar | 114 records; 5 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 299 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘PROK2’ and resolved to ‘Prokineticin-2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 114 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 19 of 19 traits by best p-value, aggregated from 22 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9HC23 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000163421/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1949485/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/PROK2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PROK2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PROK2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PROK2 — GWAS Catalog search API (live; release not exposed)