MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Systolic blood pressure automated reading | 0.0521 | 0.0146 | 3.60e-04 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest | 0.184 | 0.0532 | 5.54e-04 | Wald ratio | 1 | trans | NA |
| Hearing difficulty or problems: Yes | 0.0695 | 0.023 | 0.00254 | Wald ratio | 1 | trans | NA |
| Primary sclerosing cholangitis | -0.453 | 0.154 | 0.00335 | Wald ratio | 1 | trans | NA |
| Hippocampus volume | -66.9 | 24.8 | 0.00703 | Wald ratio | 1 | trans | NA |
| Hip osteoarthritis | 0.44 | 0.171 | 0.00986 | Wald ratio | 1 | trans | NA |
| Eye problems or disorders: Glaucoma | 0.24 | 0.0945 | 0.0111 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: high cholesterol | 0.0869 | 0.0355 | 0.0144 | Wald ratio | 1 | trans | NA |
| Microalbuminuria | 0.298 | 0.122 | 0.0145 | Wald ratio | 1 | trans | NA |
| Vascular or heart problems diagnosed by doctor: Angina | 0.166 | 0.0683 | 0.0148 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: B37 Candidiasis | 0.812 | 0.347 | 0.0194 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis | 0.246 | 0.107 | 0.0215 | Wald ratio | 1 | trans | NA |
| …and 106 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
1 association rows across 1 traits (0 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Cognitive performance (attention) (longitudinal) | 1e-6 | rs7891774 | 1 | GCST90104685 | no MR -> candidate analysis |
No genetically-associated diseases retrieved from Open Targets.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.28, LOEUF=0.888 — LoF-tolerant |
| GWAS Catalog | 2 unique SNPs / 4 rows |
| ClinVar | 211 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 33 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘PRRG1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 211 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 1 of 1 traits by best p-value, aggregated from 1 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O14668 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000130962/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/PRRG1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PRRG1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PRRG1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PRRG1 — GWAS Catalog search API (live; release not exposed)