MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Multiple sclerosis |
-0.338 |
0.088 |
1.24e-04 |
Wald ratio |
1 |
trans |
NA |
| Ulcerative colitis |
-0.242 |
0.0678 |
3.55e-04 |
Wald ratio |
1 |
trans |
NA |
| Age at menopause |
-0.358 |
0.107 |
8.58e-04 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: K43 Ventral hernia |
0.307 |
0.0952 |
0.00127 |
Inverse variance weighted |
2 |
trans |
NA |
| Diagnoses - main ICD10: K43 Ventral hernia |
0.307 |
0.0952 |
0.00127 |
Inverse variance weighted |
2 |
trans |
NA |
| Myocardial infarction |
0.128 |
0.0413 |
0.00201 |
Inverse variance weighted |
2 |
trans |
NA |
| Myocardial infarction |
0.128 |
0.0413 |
0.00201 |
Inverse variance weighted |
2 |
trans |
NA |
| Non-cancer illness code self-reported: psoriasis |
-0.335 |
0.114 |
0.00332 |
Inverse variance weighted |
2 |
trans |
NA |
| Non-cancer illness code self-reported: psoriasis |
-0.335 |
0.114 |
0.00332 |
Inverse variance weighted |
2 |
trans |
NA |
| Neo-openness to experience |
-1.12 |
0.389 |
0.00403 |
Wald ratio |
1 |
trans |
NA |
| Neuroblastoma |
-0.616 |
0.224 |
0.00588 |
Wald ratio |
1 |
trans |
NA |
| Birth length |
-0.12 |
0.0436 |
0.00603 |
Wald ratio |
1 |
trans |
NA |
| …and 153 more outcomes (see JSON) |
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|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5034_79_1 |
Trypsin 2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
43 association rows across 16 traits (39 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| CTRB1/PRSS2 protein level ratio |
3e-340 |
rs10952532 |
1 |
GCST90314308 |
no MR -> candidate analysis |
| CPB1/PRSS2 protein level ratio |
6e-339 |
rs10952532 |
1 |
GCST90314211 |
no MR -> candidate analysis |
| PLA2G1B/PRSS2 protein level ratio |
4e-152 |
rs10952532 |
1 |
GCST90315665 |
no MR -> candidate analysis |
| PRSS2 protein levels |
2e-106 |
rs3752404 |
1 |
GCST90470343 |
no MR -> candidate analysis |
| Circulating PRSS2 levels |
2e-101 |
rs4726588 |
1 |
GCST90860437 |
no MR -> candidate analysis |
| Alcoholic chronic pancreatitis |
5e-40 |
rs2855983 |
26 |
GCST004860 |
no MR -> candidate analysis |
| CTRB1 protein levels |
3e-21 |
rs1969595 |
1 |
GCST90468905 |
no MR -> candidate analysis |
| Trypsin-2 levels (PRSS2.5034.79.1) |
3e-20 |
rs13229701 |
1 |
GCST90243126 |
no MR -> candidate analysis |
| Chronic pancreatitis (PheCode 577.2) |
5e-17 |
rs2855972 |
2 |
GCST90480358 |
no MR -> candidate analysis |
| Serum levels of protein PRSS2 |
5e-14 |
rs10258394 |
1 |
GCST90088888 |
no MR -> candidate analysis |
| Trypsin-2 levels |
3e-12 |
rs28706856 |
2 |
GCST90137836 |
no MR -> candidate analysis |
| Diseases of pancreas (PheCode 577) |
3e-12 |
rs2855972 |
1 |
GCST90480360 |
no MR -> candidate analysis |
| …and 4 more traits (see JSON) |
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|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 246 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| alcoholic pancreatitis |
0.697 |
— |
common-variant locus |
no MR -> candidate analysis |
| acute pancreatitis |
0.503 |
— |
common-variant locus |
no MR -> candidate analysis |
| chronic pancreatitis |
0.505 |
— |
common-variant locus |
no MR -> candidate analysis |
| pancreatitis |
0.057 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 4 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Trypsin-2) |
| gnomAD constraint |
pLI=3.2e-07, LOEUF=1.45 — LoF-tolerant |
| GWAS Catalog |
105 unique SNPs / 209 rows |
| ClinVar |
31 records; 22 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 246 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘PRSS2’ and resolved to ‘Trypsin-2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 31 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 16 of 16 traits by best p-value, aggregated from 43 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P07478 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000275896/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3159/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/PRSS2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PRSS2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PRSS2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PRSS2 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:37:51 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none