Protein Dossier — PYY (Peptide YY)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: G47 Sleep disorders |
0.593 |
0.121 |
9.10e-07 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Arm |
0.441 |
0.108 |
4.61e-05 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N81 Female genital prolapse |
0.385 |
0.0946 |
4.74e-05 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypopituitarism |
1.19 |
0.303 |
8.85e-05 |
Wald ratio |
1 |
cis |
NA |
| Triglycerides |
0.117 |
0.0318 |
2.33e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: emphysema or chronic bronchitis |
0.362 |
0.1 |
3.14e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux |
0.216 |
0.0642 |
7.72e-04 |
Wald ratio |
1 |
cis |
NA |
| Putamen volume |
-117 |
40.8 |
0.00412 |
Wald ratio |
1 |
cis |
NA |
| HDL cholesterol |
-0.0904 |
0.0325 |
0.00536 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: osteoarthritis |
0.132 |
0.0484 |
0.00624 |
Wald ratio |
1 |
cis |
NA |
| Fasting glucose |
0.0522 |
0.0204 |
0.0104 |
Wald ratio |
1 |
cis |
NA |
| Age at menopause |
0.318 |
0.127 |
0.0124 |
Wald ratio |
1 |
cis |
NA |
| …and 97 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3727_35_1 |
PYY |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
19 association rows across 17 traits (13 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| PYY protein levels |
1e-249 |
rs8074783 |
2 |
GCST90470398 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
9e-38 |
rs573345854 |
2 |
GCST90838669 |
no MR -> candidate analysis |
| CD300LG protein levels |
3e-21 |
rs1642598 |
1 |
GCST90468623 |
no MR -> candidate analysis |
| HDL levels x fish oil supplementation interaction (2df) |
3e-16 |
rs147438979 |
1 |
GCST011927 |
no MR -> candidate analysis |
| Triglyceride levels |
1e-15 |
rs116878033 |
1 |
GCST010244 |
no MR -> candidate analysis |
| Serum levels of protein PYY |
2e-14 |
rs2341378 |
1 |
GCST90088497 |
no MR -> candidate analysis |
| Metabolic syndrome cluster 4 (lipodystrophy-like endotype) |
4e-10 |
rs147438979 |
1 |
GCST90859211 |
no MR -> candidate analysis |
| Blood protein levels |
1e-9 |
rs8074783 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Total body bone mineral density |
2e-9 |
rs116953263 |
1 |
GCST005348 |
no MR -> candidate analysis |
| DNA methylation variation (age effect) |
3e-8 |
rs4793062 |
1 |
GCST006660 |
no MR -> candidate analysis |
| Pulse pressure |
4e-8 |
rs62080325 |
1 |
GCST004278 |
no MR -> candidate analysis |
| Omega-6 fatty acid percentage of total fatty acids |
5e-8 |
rs116878033 |
1 |
GCST90454484 |
no MR -> candidate analysis |
| …and 5 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 551 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| hyperammonemia due to N-acetylglutamate synthase deficiency |
0.532 |
— |
established (curated) |
no MR -> candidate analysis |
| Hyperammonemia due to N-acetylglutamate synthetase deficiency |
0.532 |
— |
established (curated) |
no MR -> candidate analysis |
| Obesity |
0.182 |
— |
established (curated) |
MR: beta=0.729, p=0.0501 (cis) |
Of the 3 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1.9e-05, LOEUF=1.89 — LoF-tolerant |
| GWAS Catalog |
62 unique SNPs / 124 rows |
| ClinVar |
58 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 551 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘PYY’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 58 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 17 of 17 traits by best p-value, aggregated from 19 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P10082 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000131096/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/PYY — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PYY — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PYY%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PYY — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:43:07 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none