MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: enlarged prostate | 0.22 | 0.0613 | 3.28e-04 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K35 Acute appendicitis | 0.324 | 0.0934 | 5.23e-04 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | 0.0242 | 0.0073 | 9.33e-04 | Wald ratio | 1 | cis | NA |
| Myocardial infarction | -0.133 | 0.0417 | 0.00146 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: emphysema or chronic bronchitis | 0.196 | 0.0636 | 0.00209 | Wald ratio | 1 | cis | NA |
| Coronary heart disease | -0.113 | 0.0376 | 0.00263 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: high cholesterol | -0.0734 | 0.0259 | 0.00464 | Wald ratio | 1 | cis | NA |
| Sodium in urine | -0.0231 | 0.00876 | 0.0082 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.0231 | 0.00889 | 0.00954 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: asthma | 0.0579 | 0.0235 | 0.0139 | Wald ratio | 1 | cis | NA |
| Systolic blood pressure automated reading | 0.0224 | 0.00911 | 0.0139 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K80 Cholelithiasis | -0.179 | 0.0745 | 0.0166 | Wald ratio | 1 | cis | NA |
| …and 77 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
55 association rows across 30 traits (44 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Glutaminyl-peptide cyclotransferase-like protein levels | 7e-88 | rs17850756 | 2 | GCST90247790 | no MR -> candidate analysis |
| Serum levels of protein QPCTL | 3e-35 | rs17850756 | 1 | GCST90090347 | no MR -> candidate analysis |
| Body mass index | 4e-30 | rs57925894 | 11 | GCST90662887 | MR: beta=-0.0231, p=0.00954 (cis) |
| Glutaminyl-peptide cyclotransferase-like protein levels (QPC | 2e-28 | rs17850756 | 1 | GCST90241277 | no MR -> candidate analysis |
| Whole body fat mass (UKB data field 23100) | 1e-21 | rs2287019 | 1 | GCST90428121 | no MR -> candidate analysis |
| Waist-hip ratio | 1e-19 | rs2287019 | 3 | GCST008998 | no MR -> candidate analysis |
| Blood protein levels | 5e-19 | rs7256197 | 1 | GCST006585 | no MR -> candidate analysis |
| Glucose levels (UKB data field 30740) | 5e-15 | rs7256920 | 1 | GCST90468071 | no MR -> candidate analysis |
| Waist circumference | 2e-14 | rs2287019 | 3 | GCST004065 | no MR -> candidate analysis |
| Retinal arteriolar tortuosity | 1e-13 | rs11673709 | 1 | GCST90270397 | no MR -> candidate analysis |
| LDL cholesterol levels | 7e-13 | rs150184119 | 2 | GCST90244006 | no MR -> candidate analysis |
| Pulse pressure | 2e-12 | rs74889068 | 3 | GCST90132905 | no MR -> candidate analysis |
| …and 18 more traits (see JSON) |
Top diseases by Open Targets association (of 55 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| myocardial infarction | 0.435 | — | common-variant locus | MR: beta=-0.133, p=0.00146 (cis) |
| response to statin | 0.363 | — | common-variant locus | no MR -> candidate analysis |
| sleep disorder | 0.251 | — | common-variant locus | MR: beta=0.13, p=0.207 (cis) |
| Abnormality of the skeletal system | 0.226 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.103 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.073 | — | common-variant locus | no MR -> candidate analysis |
| smoking behavior | 0.068 | — | common-variant locus | no MR -> candidate analysis |
| nephrolithiasis | 0.067 | — | common-variant locus | no MR -> candidate analysis |
| myotonic syndrome | 0.058 | — | common-variant locus | no MR -> candidate analysis |
| diabetic eye disease | 0.049 | — | common-variant locus | no MR -> candidate analysis |
| coronary artery disorder | 0.048 | — | common-variant locus | no MR -> candidate analysis |
| coronary atherosclerosis | 0.045 | — | common-variant locus | no MR -> candidate analysis |
Of the 12 rows above, 10 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Glutaminyl-peptide cyclotransferase-like protein) |
| gnomAD constraint | pLI=3.4e-10, LOEUF=1.21 — LoF-tolerant |
| GWAS Catalog | 116 unique SNPs / 278 rows |
| ClinVar | 106 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 55 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘QPCTL’ and resolved to ‘Glutaminyl-peptide cyclotransferase-like protein’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 106 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 30 traits by best p-value, aggregated from 55 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9NXS2 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000011478/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3638349/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/QPCTL — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/QPCTL — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=QPCTL%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/QPCTL — GWAS Catalog search API (live; release not exposed)