MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Schizophrenia | 0.131 | 0.0391 | 7.85e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertension | 0.0457 | 0.0145 | 0.00162 | Wald ratio | 1 | cis | NA |
| Heel bone mineral density (BMD) T-score automated | 0.0335 | 0.0115 | 0.0036 | Wald ratio | 1 | cis | NA |
| Alzheimer’s disease | -0.167 | 0.059 | 0.00473 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M72 Fibroblastic disorders | 0.232 | 0.097 | 0.017 | Wald ratio | 1 | cis | NA |
| Forearm bone mineral density | 0.134 | 0.0575 | 0.0196 | Wald ratio | 1 | cis | NA |
| Lumbar spine bone mineral density | 0.0729 | 0.0324 | 0.0245 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt | -0.308 | 0.137 | 0.0249 | Wald ratio | 1 | cis | NA |
| Sodium in urine | -0.0192 | 0.00875 | 0.028 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Diabetes related eye disease | -0.375 | 0.171 | 0.0285 | Wald ratio | 1 | cis | NA |
| Lung adenocarcinoma | 0.232 | 0.109 | 0.0334 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux | -0.099 | 0.0474 | 0.0366 | Wald ratio | 1 | cis | NA |
| …and 68 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
54 association rows across 29 traits (46 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating QPCT levels | 3e-440 | rs2255991 | 4 | GCST90860490 | no MR -> candidate analysis |
| QPCT protein levels | 1e-199 | rs72792854 | 5 | GCST90470401 | no MR -> candidate analysis |
| Height | 3e-90 | rs7593932 | 8 | GCST90245848 | no MR -> candidate analysis |
| Cerebrospinal fluid protein QPCT levels | 9e-79 | rs12467820 | 1 | GCST90944879 | no MR -> candidate analysis |
| Glutaminyl-peptide cyclotransferase levels | 5e-60 | rs12467820 | 2 | GCST90427104 | no MR -> candidate analysis |
| Serum levels of protein QPCT | 2e-33 | rs12467820 | 1 | GCST90089874 | no MR -> candidate analysis |
| Pyroglutamylglutamine levels | 9e-31 | rs77684493 | 1 | GCST90140299 | no MR -> candidate analysis |
| Blood protein levels | 4e-28 | rs13027919 | 1 | GCST006585 | no MR -> candidate analysis |
| Systolic blood pressure | 5e-20 | rs13419498 | 2 | GCST90310294 | MR: beta=0.0082, p=0.367 (cis) |
| Systolic blood pressure (MTAG) | 1e-17 | rs6734118 | 1 | GCST90449056 | no MR -> candidate analysis |
| Fasting blood glucose | 2e-15 | rs13027919 | 1 | GCST90662896 | no MR -> candidate analysis |
| Diastolic blood pressure | 2e-13 | rs13419498 | 1 | GCST90310295 | no MR -> candidate analysis |
| …and 17 more traits (see JSON) |
Top diseases by Open Targets association (of 160 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Alzheimer disease | 0.039 | — | common-variant locus | no MR -> candidate analysis |
| schizophrenia | 0.502 | — | common-variant locus | MR: beta=0.131, p=7.85e-04 (cis) |
| head injury | 0.416 | — | common-variant locus | no MR -> candidate analysis |
| hypertensive disorder | 0.212 | — | common-variant locus | no MR -> candidate analysis |
| response to xenobiotic stimulus | 0.188 | — | common-variant locus | no MR -> candidate analysis |
| Hallux valgus | 0.111 | — | common-variant locus | no MR -> candidate analysis |
| atrial fibrillation | 0.1 | — | common-variant locus | MR: beta=0.0791, p=0.313 (cis) |
| heart failure | 0.092 | — | common-variant locus | no MR -> candidate analysis |
| premature birth | 0.092 | — | common-variant locus | no MR -> candidate analysis |
| essential hypertension | 0.091 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.09 | — | common-variant locus | no MR -> candidate analysis |
| COVID-19 | 0.078 | — | common-variant locus | no MR -> candidate analysis |
| esophageal ulcer | 0.078 | — | common-variant locus | no MR -> candidate analysis |
| ovarian neoplasm | 0.076 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.061 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Glutaminyl-peptide cyclotransferase) |
| gnomAD constraint | pLI=1.1e-15, LOEUF=1.3 — LoF-tolerant |
| GWAS Catalog | 71 unique SNPs / 142 rows |
| ClinVar | 106 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 160 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘QPCT’ and resolved to ‘Glutaminyl-peptide cyclotransferase’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 106 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 29 traits by best p-value, aggregated from 54 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q16769 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000115828/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4508/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/QPCT — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/QPCT — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=QPCT%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/QPCT — GWAS Catalog search API (live; release not exposed)