MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Forced vital capacity (FVC) | 0.0255 | 0.00553 | 3.83e-06 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | 0.0234 | 0.00583 | 5.98e-05 | Wald ratio | 1 | cis | NA |
| Sodium in urine | -0.0262 | 0.00663 | 7.98e-05 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: high cholesterol | 0.0593 | 0.0172 | 5.54e-04 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | 0.022 | 0.0069 | 0.00141 | Wald ratio | 1 | cis | NA |
| Underlying (primary) cause of death: ICD10: E85.4 Organ-limited amyloidosis | 1.42 | 0.449 | 0.0016 | Wald ratio | 1 | cis | NA |
| Rheumatoid arthritis | -0.144 | 0.0524 | 0.00611 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Arm | 0.153 | 0.0584 | 0.00864 | Wald ratio | 1 | cis | NA |
| Sleep duration | -0.0137 | 0.00526 | 0.00936 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | -0.0255 | 0.00996 | 0.0103 | Wald ratio | 1 | cis | NA |
| Weight | 0.015 | 0.00595 | 0.0117 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level | 0.299 | 0.128 | 0.0191 | Wald ratio | 1 | cis | NA |
| …and 73 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
156 association rows across 75 traits (148 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Height | 1e-300 | rs7038554 | 30 | GCST90245843 | no MR -> candidate analysis |
| height (mean, inv-normal transformed) | 1e-207 | rs7849585 | 4 | GCST90475362 | no MR -> candidate analysis |
| Height (maximum, inv-normal transformed) | 3e-203 | rs7849585 | 3 | GCST90475359 | no MR -> candidate analysis |
| height (minimum, inv-normal transformed) | 1e-168 | rs62578989 | 3 | GCST90475365 | no MR -> candidate analysis |
| What is your height? (cm, inv-normal transformed) | 2e-107 | rs62578989 | 2 | GCST90475368 | no MR -> candidate analysis |
| Standing height (UKB data field 50) | 2e-61 | rs7038554 | 1 | GCST90468178 | no MR -> candidate analysis |
| Free thyroxine levels within normal range in pregnancy | 3e-55 | rs10858249 | 1 | GCST90435196 | no MR -> candidate analysis |
| Height (baseline) | 6e-53 | rs7038554 | 2 | GCST90565843 | no MR -> candidate analysis |
| Body size or adipose distribution (multivariate analysis) | 1e-52 | rs4842134 | 1 | GCST90624105 | no MR -> candidate analysis |
| Sulfhydryl oxidase 2 levels (QSOX2.8397.147.3) | 2e-50 | rs10858248 | 2 | GCST90242914 | no MR -> candidate analysis |
| Physical function (baseline) | 1e-37 | rs12684650 | 1 | GCST90565837 | no MR -> candidate analysis |
| FVC | 5e-34 | rs12684650 | 1 | GCST90270083 | MR: beta=0.0255, p=3.83e-06 (cis) |
| …and 63 more traits (see JSON) |
Top diseases by Open Targets association (of 94 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| insomnia | 0.572 | — | common-variant locus | no MR -> candidate analysis |
| refractive error | 0.459 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.399 | — | common-variant locus | no MR -> candidate analysis |
| atrial fibrillation | 0.221 | — | common-variant locus | MR: beta=-0.0747, p=0.28 (cis) |
| Abnormality of refraction | 0.215 | — | common-variant locus | no MR -> candidate analysis |
| Inguinal hernia | 0.166 | — | common-variant locus | MR: beta=0.0783, p=0.04 (cis) |
| Hernia | 0.128 | — | common-variant locus | MR: beta=0.179, p=0.0357 (cis) |
| Abnormality of the skeletal system | 0.107 | — | common-variant locus | no MR -> candidate analysis |
Of the 8 rows above, 5 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=3.6e-12, LOEUF=0.953 — LoF-tolerant |
| GWAS Catalog | 78 unique SNPs / 156 rows |
| ClinVar | 221 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 94 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘QSOX2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 221 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 75 traits by best p-value, aggregated from 156 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q6ZRP7 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000165661/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/QSOX2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/QSOX2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=QSOX2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/QSOX2 — GWAS Catalog search API (live; release not exposed)