MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: K43 Ventral hernia | 0.106 | 0.0338 | 0.00167 | Wald ratio | 1 | cis | NA |
| Height | -0.00973 | 0.00314 | 0.00197 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain | 0.0281 | 0.0118 | 0.017 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: J33 Nasal polyp | 0.0801 | 0.0336 | 0.0172 | Wald ratio | 1 | cis | NA |
| Sodium in urine | 0.00562 | 0.00247 | 0.0226 | Wald ratio | 1 | cis | NA |
| Squamous cell lung cancer | 0.0668 | 0.0313 | 0.033 | Wald ratio | 1 | cis | NA |
| Ovarian cancer | -0.0289 | 0.0139 | 0.0375 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: D12 Benign neoplasm of colon rectum anus and anal canal | -0.0443 | 0.0221 | 0.0451 | Wald ratio | 1 | cis | NA |
| Depressive symptoms | 0.00748 | 0.00374 | 0.0455 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine | 0.0334 | 0.0171 | 0.0501 | Wald ratio | 1 | cis | NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0235 | 0.012 | 0.0511 | Wald ratio | 1 | cis | NA |
| Putamen volume | 11.8 | 6.06 | 0.0516 | Wald ratio | 1 | cis | NA |
| …and 101 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
15 association rows across 10 traits (13 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating RARRES1 levels | 6e-1014 | rs6441224 | 2 | GCST90860306 | no MR -> candidate analysis |
| Retinoic acid receptor responder protein 1 levels (RARRES1.8 | 7e-514 | rs112493023 | 3 | GCST90242640 | no MR -> candidate analysis |
| Blood protein levels | 5e-481 | rs73030851 | 1 | GCST006585 | no MR -> candidate analysis |
| Retinoic acid receptor responder protein 1 levels | 2e-333 | rs17699997 | 2 | GCST90249381 | no MR -> candidate analysis |
| Circulating LXN levels | 6e-97 | rs1548013 | 1 | GCST90859687 | no MR -> candidate analysis |
| RARRES1 protein levels | 5e-30 | rs74516361 | 2 | GCST90470427 | no MR -> candidate analysis |
| Mouth ulcers | 4e-11 | rs73156502 | 1 | GCST007839 | no MR -> candidate analysis |
| Systolic blood pressure | 2e-9 | rs9849301 | 1 | GCST007267 | MR: beta=-0.00199, p=0.438 (cis) |
| C.albicans induced TNF-a level | 5e-7 | rs16829318 | 1 | GCST90308659 | no MR -> candidate analysis |
| Diisocyanate-induced asthma | 2e-6 | rs190141647 | 1 | GCST002875 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 192 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| premature birth | 0.566 | — | common-variant locus | no MR -> candidate analysis |
| placental retention | 0.46 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.421 | — | common-variant locus | no MR -> candidate analysis |
| pathological myopia | 0.421 | — | common-variant locus | no MR -> candidate analysis |
| Oral ulcer | 0.393 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.356 | — | common-variant locus | no MR -> candidate analysis |
| congestive heart failure | 0.112 | — | common-variant locus | no MR -> candidate analysis |
| neuroblastoma | 0.097 | — | common-variant locus | no MR -> candidate analysis |
| chronic obstructive pulmonary disease | 0.088 | — | common-variant locus | no MR -> candidate analysis |
| major depressive disorder | 0.078 | — | common-variant locus | no MR -> candidate analysis |
| bipolar disorder | 0.053 | — | common-variant locus | MR: beta=0.0383, p=0.419 (cis) |
| handedness | 0.049 | — | common-variant locus | no MR -> candidate analysis |
Of the 12 rows above, 11 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=3.1e-13, LOEUF=1.48 — LoF-tolerant |
| GWAS Catalog | 48 unique SNPs / 96 rows |
| ClinVar | 104 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 192 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘RARRES1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 104 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 10 of 10 traits by best p-value, aggregated from 15 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P49788 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000118849/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/RARRES1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/RARRES1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=RARRES1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/RARRES1 — GWAS Catalog search API (live; release not exposed)