Protein Dossier — RARRES2 (Retinoic acid receptor responder protein 2)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Thyroid cancer |
-1.35 |
0.268 |
4.54e-07 |
Wald ratio |
1 |
cis |
NA |
| Sodium in urine |
0.0276 |
0.00716 |
1.15e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
-0.0366 |
0.0129 |
0.0045 |
Wald ratio |
1 |
cis |
NA |
| Knee osteoarthritis |
-0.222 |
0.0817 |
0.00668 |
Wald ratio |
1 |
cis |
NA |
| Knee and hip osteoarthritis |
-0.168 |
0.0621 |
0.00691 |
Wald ratio |
1 |
cis |
NA |
| Creatinine (enzymatic) in urine |
0.0186 |
0.00697 |
0.00749 |
Wald ratio |
1 |
cis |
NA |
| Alzheimer’s disease |
-0.113 |
0.0469 |
0.0165 |
Wald ratio |
1 |
cis |
NA |
| Systolic blood pressure automated reading |
-0.0168 |
0.00745 |
0.0243 |
Wald ratio |
1 |
cis |
NA |
| Potassium in urine |
0.0166 |
0.00739 |
0.0245 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level |
0.301 |
0.138 |
0.0288 |
Wald ratio |
1 |
cis |
NA |
| Diastolic blood pressure automated reading |
-0.0155 |
0.00745 |
0.0374 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: H25 Senile cataract |
0.147 |
0.0721 |
0.0417 |
Wald ratio |
1 |
cis |
NA |
| …and 96 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3079_62_2 |
TIG2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
24 association rows across 17 traits (20 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating RARRES2 levels |
1e-385 |
rs3735167 |
1 |
GCST90859990 |
no MR -> candidate analysis |
| RARRES2 protein levels |
1e-216 |
rs3735167 |
1 |
GCST90470428 |
no MR -> candidate analysis |
| Retinoic acid receptor responder protein 2 levels |
6e-115 |
rs3735167 |
5 |
GCST90249382 |
no MR -> candidate analysis |
| Serum levels of protein RARRES2 |
1e-71 |
rs2098053 |
1 |
GCST90088227 |
no MR -> candidate analysis |
| Blood protein levels |
9e-46 |
rs3735167 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein RARRES2 levels |
1e-34 |
rs57367026 |
1 |
GCST90945039 |
no MR -> candidate analysis |
| Chemerin levels |
2e-21 |
rs3735167 |
1 |
GCST007900 |
no MR -> candidate analysis |
| Height |
1e-13 |
rs3735167 |
1 |
GCST90245848 |
MR: beta=-0.00864, p=0.349 (cis) |
| Impedance of whole body (UKB data field 23106) |
6e-12 |
rs10952252 |
1 |
GCST90468173 |
no MR -> candidate analysis |
| Protein levels in obesity |
2e-10 |
rs10282458 |
1 |
GCST010196 |
no MR -> candidate analysis |
| Circulating chemerin levels |
2e-10 |
rs10259796 |
2 |
GCST004389 |
no MR -> candidate analysis |
| Systolic blood pressure |
3e-10 |
rs11771693 |
2 |
GCST006624 |
MR: beta=-0.0168, p=0.0243 (cis) |
| …and 5 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 565 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Abnormality of the skeletal system |
0.693 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.0015, LOEUF=1.08 — LoF-tolerant |
| GWAS Catalog |
39 unique SNPs / 78 rows |
| ClinVar |
114 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 565 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘RARRES2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 114 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 17 of 17 traits by best p-value, aggregated from 24 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q99969 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000106538/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/RARRES2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/RARRES2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=RARRES2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/RARRES2 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:45:45 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none