Protein Dossier — RETN (Resistin)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Multiple sclerosis |
-0.62 |
0.132 |
2.59e-06 |
Wald ratio |
1 |
trans |
NA |
| Hip osteoarthritis |
-0.65 |
0.212 |
0.00213 |
Wald ratio |
1 |
trans |
NA |
| Fasting proinsulin |
-0.159 |
0.0559 |
0.00452 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
-0.00309 |
0.00117 |
0.00804 |
Inverse variance weighted |
3 |
cis |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
-0.00309 |
0.00117 |
0.00804 |
Inverse variance weighted |
3 |
trans |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
-0.00309 |
0.00117 |
0.00804 |
Inverse variance weighted |
3 |
trans |
NA |
| Non-cancer illness code self-reported: enlarged prostate |
-0.00215 |
0.000946 |
0.0229 |
Inverse variance weighted |
3 |
cis |
NA |
| Non-cancer illness code self-reported: enlarged prostate |
-0.00215 |
0.000946 |
0.0229 |
Inverse variance weighted |
3 |
trans |
NA |
| Non-cancer illness code self-reported: enlarged prostate |
-0.00215 |
0.000946 |
0.0229 |
Inverse variance weighted |
3 |
trans |
NA |
| Crohn’s disease |
-0.208 |
0.0972 |
0.0326 |
Wald ratio |
1 |
trans |
NA |
| Knee and hip osteoarthritis |
-0.354 |
0.166 |
0.033 |
Wald ratio |
1 |
trans |
NA |
| Major depressive disorder |
0.343 |
0.165 |
0.0374 |
Wald ratio |
1 |
trans |
NA |
| …and 193 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3046_31_1 |
resistin |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
41 association rows across 15 traits (39 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Resistin levels |
2e-858 |
rs3219175 |
20 |
GCST003759 |
no MR -> candidate analysis |
| Circulating RETN levels |
4e-481 |
rs3745368 |
6 |
GCST90859950 |
no MR -> candidate analysis |
| LCN2/RETN protein level ratio |
2e-437 |
rs34124816 |
1 |
GCST90315308 |
no MR -> candidate analysis |
| COL18A1/RETN protein level ratio |
1e-287 |
rs34124816 |
1 |
GCST90314170 |
no MR -> candidate analysis |
| CST3/RETN protein level ratio |
4e-274 |
rs34124816 |
1 |
GCST90314297 |
no MR -> candidate analysis |
| RETN/RNASET2 protein level ratio |
3e-273 |
rs34124816 |
1 |
GCST90315768 |
no MR -> candidate analysis |
| RETN protein levels |
1e-92 |
rs35547567 |
2 |
GCST90470457 |
no MR -> candidate analysis |
| Resistin levels in overweight individuals |
6e-64 |
rs3219175 |
1 |
GCST90091185 |
no MR -> candidate analysis |
| Resistin levels in type 2 diabetes |
3e-59 |
rs3219175 |
1 |
GCST90091204 |
no MR -> candidate analysis |
| Resistin levels in lean individuals |
2e-50 |
rs3219175 |
1 |
GCST90091174 |
no MR -> candidate analysis |
| Resistin level in Chronic kidney disease with hypertension a |
1e-47 |
rs3219175 |
1 |
GCST90237214 |
no MR -> candidate analysis |
| Cerebrospinal fluid biomarker levels |
6e-39 |
rs3219175 |
1 |
GCST004000 |
no MR -> candidate analysis |
| …and 3 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 745 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| autism |
0.182 |
— |
established (curated) |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.018, LOEUF=1.73 — LoF-tolerant |
| GWAS Catalog |
111 unique SNPs / 266 rows |
| ClinVar |
26 records; 5 pathogenic in sample of 26 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 745 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘RETN’.clinvar — Pathogenic count is over the 26 record(s) retrieved, NOT over all 26 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 15 of 15 traits by best p-value, aggregated from 41 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9HD89 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000104918/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/RETN — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/RETN — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=RETN%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/RETN — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:48:22 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none