Protein Dossier — RGMB (Repulsive guidance molecule B)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Creatinine (enzymatic) in urine |
-0.0403 |
0.0108 |
1.87e-04 |
Wald ratio |
1 |
cis |
NA |
| Potassium in urine |
-0.0354 |
0.0114 |
0.00193 |
Wald ratio |
1 |
cis |
NA |
| Forced expiratory volume in 1-second (FEV1) |
-0.0297 |
0.00976 |
0.00231 |
Wald ratio |
1 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
-0.0414 |
0.0146 |
0.00457 |
Wald ratio |
1 |
cis |
NA |
| Neuroticism |
-0.037 |
0.0139 |
0.00766 |
Wald ratio |
1 |
cis |
NA |
| Height |
-0.0356 |
0.0139 |
0.0103 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb |
0.184 |
0.0717 |
0.0103 |
Wald ratio |
1 |
cis |
NA |
| Small vessel disease |
-0.411 |
0.161 |
0.0106 |
Wald ratio |
1 |
cis |
NA |
| Depressive symptoms |
-0.0324 |
0.0139 |
0.0196 |
Wald ratio |
1 |
cis |
NA |
| Myocardial infarction |
-0.111 |
0.0486 |
0.0222 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip] |
-0.282 |
0.127 |
0.0262 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: enlarged prostate |
0.177 |
0.0813 |
0.029 |
Wald ratio |
1 |
cis |
NA |
| …and 115 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3331_8_1 |
RGMB |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
16 association rows across 13 traits (15 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| RGMB protein levels |
1e-52 |
rs1053451 |
2 |
GCST90470464 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
1e-27 |
rs79997895 |
2 |
GCST90838669 |
no MR -> candidate analysis |
| Height |
3e-21 |
rs10479243 |
2 |
GCST90245848 |
MR: beta=-0.0356, p=0.0103 (cis) |
| RGM domain family member B levels |
1e-20 |
rs11370451 |
1 |
GCST90249294 |
no MR -> candidate analysis |
| Forced expiratory volume in 1 second (FEV1) |
2e-14 |
rs1508793 |
1 |
GCST90705070 |
no MR -> candidate analysis |
| Lung function (FEV1) |
2e-13 |
rs2249797 |
1 |
GCST90244092 |
no MR -> candidate analysis |
| Appendicular lean mass |
4e-11 |
rs331917 |
1 |
GCST90000025 |
no MR -> candidate analysis |
| Basophil percentage of granulocytes |
3e-10 |
rs111887461 |
1 |
GCST004634 |
no MR -> candidate analysis |
| Hair color |
3e-9 |
rs2617515 |
1 |
GCST007082 |
no MR -> candidate analysis |
| Depression severity x hours spent watching television inter |
2e-8 |
rs2662263 |
1 |
GCST90101750 |
no MR -> candidate analysis |
| Forced vital capacity (FVC) |
2e-8 |
rs2249797 |
1 |
GCST90705071 |
MR: beta=-0.0122, p=0.188 (cis) |
| Hip minimal joint space width |
4e-8 |
rs2545730 |
1 |
GCST90281365 |
no MR -> candidate analysis |
| …and 1 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 140 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Abnormality of the skeletal system |
0.658 |
— |
common-variant locus |
no MR -> candidate analysis |
| carpal tunnel syndrome |
0.586 |
— |
common-variant locus |
no MR -> candidate analysis |
| benign prostatic hyperplasia |
0.536 |
— |
common-variant locus |
no MR -> candidate analysis |
| Peyronie disease |
0.487 |
— |
common-variant locus |
no MR -> candidate analysis |
| osteoarthritis |
0.482 |
— |
common-variant locus |
MR: beta=-0.05, p=0.208 (cis) |
| frozen shoulder |
0.44 |
— |
common-variant locus |
no MR -> candidate analysis |
| glomerulonephritis |
0.44 |
— |
common-variant locus |
no MR -> candidate analysis |
| physical activity |
0.426 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.397 |
— |
common-variant locus |
no MR -> candidate analysis |
| trauma complication |
0.387 |
— |
common-variant locus |
no MR -> candidate analysis |
| cataract |
0.387 |
— |
common-variant locus |
MR: beta=-0.0846, p=0.209 (cis) |
| placental retention |
0.387 |
— |
common-variant locus |
no MR -> candidate analysis |
| Constipation |
0.362 |
— |
common-variant locus |
no MR -> candidate analysis |
| hemorrhoid |
0.358 |
— |
common-variant locus |
no MR -> candidate analysis |
| disorder of ear |
0.354 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=0.001, LOEUF=0.904 — LoF-tolerant |
| GWAS Catalog |
22 unique SNPs / 43 rows |
| ClinVar |
107 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 140 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘RGMB’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 107 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 13 of 13 traits by best p-value, aggregated from 16 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q6NW40 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000174136/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/RGMB — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/RGMB — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=RGMB%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/RGMB — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:49:15 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none