CausalSentinel

Protein Dossier — RNASE3 (Eosinophil cationic protein)

MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).

1. Published MR estimates (retrieved, not computed)

Outcome	beta	se	p	method	nSNP	cis/trans	coloc
ER-positive Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis)	0.129	0.0444	0.00379	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: pneumothorax	0.823	0.316	0.00915	Wald ratio	1	cis	NA
Diagnoses - main ICD10: D25 Leiomyoma of uterus	-0.495	0.199	0.0127	Wald ratio	1	cis	NA
Heel bone mineral density (BMD) T-score automated	-0.0398	0.0169	0.0186	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: kidney stone or ureter stone or bladder stone	0.238	0.118	0.0445	Wald ratio	1	cis	NA
Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis)	0.0734	0.0369	0.0469	Wald ratio	1	cis	NA
Diagnoses - main ICD10: K80 Cholelithiasis	0.152	0.0789	0.0546	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux	0.109	0.0567	0.0551	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: hypertension	0.0383	0.0215	0.0742	Wald ratio	1	cis	NA
Diagnoses - main ICD10: G56 Mononeuropathies of upper limb	0.15	0.0864	0.0817	Wald ratio	1	cis	NA
Schizophrenia	0.1	0.0593	0.0905	Wald ratio	1	cis	NA
Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis	0.254	0.153	0.0967	Wald ratio	1	cis	NA
…and 59 more outcomes (see JSON)

2. pQTL instrument availability (Tier-B probe)

No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).

3. GWAS Catalog results — traits with signal at this locus

37 association rows across 28 traits (32 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.

Trait	best p	lead SNP	n assoc	study	MR status
AZU1/RNASE3 protein level ratio	1e-422	rs112539509	1	GCST90313428	no MR -> candidate analysis
Circulating RNASE3 levels	2e-409	rs1763559	1	GCST90860416	no MR -> candidate analysis
RNASE1 protein levels	2e-208	rs12885981	3	GCST90470476	no MR -> candidate analysis
Eosinophil cationic protein (analyte X15576.158) levels	6e-164	rs4982376	1	GCST90422739	no MR -> candidate analysis
Non-secretory ribonuclease levels	9e-126	rs2233859	1	GCST90248708	no MR -> candidate analysis
Monocyte side fluorescence	1e-59	rs6571511	2	GCST90281241	no MR -> candidate analysis
Ribonuclease pancreatic levels	8e-53	rs17254387	2	GCST90249353	no MR -> candidate analysis
RNASE3 protein levels	3e-51	rs117558322	2	GCST90470477	no MR -> candidate analysis
Serum levels of protein RNASE2	1e-35	rs2233859	1	GCST90090180	no MR -> candidate analysis
Serum levels of protein RNASE1	2e-35	rs17254387	2	GCST90089740	no MR -> candidate analysis
Circulating CTRC levels	8e-29	rs35775091	1	GCST90859776	no MR -> candidate analysis
Blood protein levels	3e-25	rs12885981	1	GCST006585	no MR -> candidate analysis
…and 16 more traits (see JSON)

4. Phenome map — where this gene is a genetic locus, vs. where MR exists

No genetically-associated diseases retrieved from Open Targets.

5. Downstream annotation (druggability & safety preview)

Layer	Result
ChEMBL druggability	not available — no ChEMBL target (undrugged)
gnomAD constraint	pLI=NA, LOEUF=NA — Constraint metrics missing; LoF tolerance cannot be judged.
GWAS Catalog	65 unique SNPs / 130 rows
ClinVar	60 records; 3 pathogenic in sample of 30
PharmGKB/ClinPGx	no annotations

Caveats declared by the tools

• phenome — Top 30 of 558 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.
• chembl — No ChEMBL target for ‘RNASE3’.
• clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 60 ClinVar records for this gene; it is a sample, not a rate.
• pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).
• gwas_traits — Top 20 of 28 traits by best p-value, aggregated from 37 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.

Sources

• uniprot: https://www.uniprot.org/uniprotkb/P12724 — UniProt release 2026_02 (10-June-2026)
• mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0
• phenome: https://platform.opentargets.org/target/ENSG00000169397/associations — Open Targets data release 26.06
• gnomad: https://gnomad.broadinstitute.org/gene/RNASE3 — gnomAD constraint via GraphQL API (reference genome GRCh38)
• gwas: https://www.ebi.ac.uk/gwas/genes/RNASE3 — GWAS Catalog REST (live; release not exposed by this endpoint)
• clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=RNASE3%5Bgene%5D — ClinVar build Build260809-1055.1
• gwas_traits: https://www.ebi.ac.uk/gwas/genes/RNASE3 — GWAS Catalog search API (live; release not exposed)

Provenance

• Generated: 2026-08-14T04:50:32 · Tier: A
• Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
• MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
• Tool errors this run: none

This site is open source. Improve this page.