Protein Dossier — SCARF1 (Scavenger receptor class F member 1)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Depressive symptoms |
0.0187 |
0.00678 |
0.00596 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: muscle or soft tissue injuries |
0.139 |
0.0522 |
0.00761 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Other bones |
0.0528 |
0.0209 |
0.0115 |
Wald ratio |
1 |
cis |
NA |
| Serum cystatin C (eGFRcys) |
0.00933 |
0.0039 |
0.0168 |
Wald ratio |
1 |
cis |
NA |
| Squamous cell lung cancer |
-0.123 |
0.0524 |
0.0186 |
Wald ratio |
1 |
cis |
NA |
| Fractured or broken bones in last 5 years |
0.0349 |
0.0153 |
0.0224 |
Wald ratio |
1 |
cis |
NA |
| Glioma |
0.201 |
0.0917 |
0.0285 |
Wald ratio |
1 |
cis |
NA |
| Eczema |
-0.0763 |
0.0349 |
0.0288 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
0.0177 |
0.00849 |
0.0373 |
Wald ratio |
1 |
cis |
NA |
| Alzheimer’s disease |
-0.067 |
0.0322 |
0.0376 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K60 Fissure and fistula of anal and rectal regions |
-0.184 |
0.0911 |
0.0429 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N81 Female genital prolapse |
0.0781 |
0.0392 |
0.0464 |
Wald ratio |
1 |
cis |
NA |
| …and 96 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5129_12_3 |
SREC-I |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
32 association rows across 22 traits (32 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| DAG1/SCARF1 protein level ratio |
8e-1454 |
rs2272011 |
1 |
GCST90314381 |
no MR -> candidate analysis |
| SCARF1/TNFRSF14 protein level ratio |
3e-1355 |
rs2272011 |
1 |
GCST90315812 |
no MR -> candidate analysis |
| ESAM/SCARF1 protein level ratio |
2e-1310 |
rs2272011 |
1 |
GCST90314715 |
no MR -> candidate analysis |
| PEAR1/SCARF1 protein level ratio |
9e-1003 |
rs2272011 |
1 |
GCST90315642 |
no MR -> candidate analysis |
| SCARF1/SUSD1 protein level ratio |
9e-973 |
rs2272011 |
1 |
GCST90315811 |
no MR -> candidate analysis |
| Circulating SCARF1 levels |
1e-841 |
rs2272011 |
5 |
GCST90860642 |
no MR -> candidate analysis |
| Scavenger receptor class F member 1 levels |
3e-118 |
rs2272011 |
5 |
GCST90249444 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein SCARF1 levels |
4e-99 |
rs76081968 |
1 |
GCST90944886 |
no MR -> candidate analysis |
| Serum levels of protein SCARF1 |
4e-93 |
rs2272011 |
1 |
GCST90088945 |
no MR -> candidate analysis |
| SCARF1 protein levels |
2e-39 |
rs186669865 |
2 |
GCST90470536 |
no MR -> candidate analysis |
| Mean platelet thrombocyte volume (UKB data field 30100) |
7e-28 |
rs113487086 |
1 |
GCST90468087 |
no MR -> candidate analysis |
| Scavenger receptor class F member 1 level in Chronic kidney |
8e-24 |
rs2272011 |
1 |
GCST90237863 |
no MR -> candidate analysis |
| …and 10 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 440 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| brain aneurysm |
0.511 |
— |
common-variant locus |
no MR -> candidate analysis |
| rhabdomyolysis |
0.325 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1.4e-10, LOEUF=0.814 — LoF-tolerant |
| GWAS Catalog |
103 unique SNPs / 218 rows |
| ClinVar |
270 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 440 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘SCARF1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 270 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 22 traits by best p-value, aggregated from 32 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q14162 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000074660/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/SCARF1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SCARF1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SCARF1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SCARF1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:55:52 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none