Protein Dossier — SCARF2 (Scavenger receptor class F member 2)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Forced expiratory volume in 1-second (FEV1) |
0.0404 |
0.00878 |
4.14e-06 |
Wald ratio |
1 |
cis |
NA |
| Fasting insulin |
-0.04 |
0.0133 |
0.0027 |
Wald ratio |
1 |
cis |
NA |
| Weight |
0.0258 |
0.00897 |
0.00397 |
Wald ratio |
1 |
cis |
NA |
| Thyroid cancer |
1.13 |
0.41 |
0.00573 |
Wald ratio |
1 |
cis |
NA |
| Vascular or heart problems diagnosed by doctor: Angina |
0.134 |
0.05 |
0.00749 |
Wald ratio |
1 |
cis |
NA |
| Age at menarche |
0.0634 |
0.0246 |
0.01 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N40 Hyperplasia of prostate |
0.22 |
0.0856 |
0.0103 |
Wald ratio |
1 |
cis |
NA |
| Height |
0.029 |
0.0127 |
0.0221 |
Wald ratio |
1 |
cis |
NA |
| Schizophrenia |
-0.103 |
0.0457 |
0.0241 |
Wald ratio |
1 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
0.0293 |
0.0132 |
0.0259 |
Wald ratio |
1 |
cis |
NA |
| Depressive symptoms |
0.0367 |
0.0167 |
0.0278 |
Wald ratio |
1 |
cis |
NA |
| Melanoma |
0.477 |
0.229 |
0.037 |
Wald ratio |
1 |
cis |
NA |
| …and 107 more outcomes (see JSON) |
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|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5130_67_3 |
SREC-II |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
47 association rows across 31 traits (46 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating SCARF2 levels |
1e-738 |
rs9610955 |
4 |
GCST90859705 |
no MR -> candidate analysis |
| Height |
2e-144 |
rs1477178 |
7 |
GCST90245848 |
MR: beta=0.029, p=0.0221 (cis) |
| Scavenger receptor class F member 2 levels |
4e-58 |
rs738084 |
3 |
GCST90249445 |
no MR -> candidate analysis |
| SCARF2 protein levels |
2e-39 |
rs12483784 |
2 |
GCST90470537 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein SCARF2 levels |
1e-35 |
rs738084 |
1 |
GCST90944551 |
no MR -> candidate analysis |
| FEV1/FVC ratio |
2e-32 |
rs5763025 |
1 |
GCST90705072 |
no MR -> candidate analysis |
| Lung function (FEV1/FVC) |
2e-27 |
rs5763025 |
3 |
GCST90244094 |
no MR -> candidate analysis |
| FEV1 FVC ratio Z score (UKB data field 20258) |
3e-24 |
rs738084 |
1 |
GCST90468165 |
no MR -> candidate analysis |
| Height (baseline) |
2e-23 |
rs12628193 |
3 |
GCST90565843 |
no MR -> candidate analysis |
| Standing height (UKB data field 50) |
2e-23 |
rs874100 |
1 |
GCST90468178 |
no MR -> candidate analysis |
| Scavenger receptor class F member 2 levels (SCARF2.8956.96.3 |
5e-21 |
rs738086 |
1 |
GCST90242719 |
no MR -> candidate analysis |
| Body shape phenotype PC2 |
7e-21 |
rs12628193 |
1 |
GCST90832990 |
no MR -> candidate analysis |
| …and 19 more traits (see JSON) |
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|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 285 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| van den Ende-Gupta syndrome |
0.803 |
— |
established (curated) |
no MR -> candidate analysis |
| Abnormality of the skeletal system |
0.895 |
— |
common-variant locus |
no MR -> candidate analysis |
| open-angle glaucoma |
0.56 |
— |
common-variant locus |
no MR -> candidate analysis |
| COVID-19 |
0.521 |
— |
common-variant locus |
no MR -> candidate analysis |
| severe acute respiratory syndrome |
0.521 |
— |
common-variant locus |
no MR -> candidate analysis |
| poisoning |
0.475 |
— |
common-variant locus |
no MR -> candidate analysis |
| response to xenobiotic stimulus |
0.475 |
— |
common-variant locus |
no MR -> candidate analysis |
| hereditary disease |
0.319 |
— |
established (curated) |
no MR -> candidate analysis |
| microcephaly |
0.182 |
— |
established (curated) |
no MR -> candidate analysis |
Of the 9 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=6.9e-06, LOEUF=0.694 — LoF-tolerant |
| GWAS Catalog |
45 unique SNPs / 90 rows |
| ClinVar |
684 records; 20 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 285 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘SCARF2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 684 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 31 traits by best p-value, aggregated from 47 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q96GP6 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000244486/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/SCARF2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SCARF2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SCARF2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SCARF2 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:56:06 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none