MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Sodium in urine | -0.0323 | 0.012 | 0.00696 | Wald ratio | 1 | trans | NA |
| Schizophrenia | 0.143 | 0.0543 | 0.00841 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: K80 Cholelithiasis | -0.269 | 0.113 | 0.0167 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R11 Nausea and vomiting | 0.333 | 0.142 | 0.0189 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: arthritis (nos) | 0.214 | 0.115 | 0.0618 | Wald ratio | 1 | trans | NA |
| Hirschsprung’s disease | -0.817 | 0.455 | 0.0727 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter | 0.212 | 0.119 | 0.0744 | Wald ratio | 1 | trans | NA |
| Eczema | 0.177 | 0.0998 | 0.0754 | Wald ratio | 1 | trans | NA |
| Systolic blood pressure automated reading | 0.0219 | 0.0124 | 0.0789 | Wald ratio | 1 | trans | NA |
| Thalamus volume | -65.5 | 37.3 | 0.0795 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest | -0.106 | 0.0605 | 0.081 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms | -0.206 | 0.124 | 0.0957 | Wald ratio | 1 | trans | NA |
| …and 56 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
31 association rows across 21 traits (16 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Height | 4e-53 | rs1990224 | 9 | GCST90245848 | no MR -> candidate analysis |
| Adseverin levels | 1e-22 | rs56357458 | 2 | GCST90246446 | no MR -> candidate analysis |
| Height (baseline) | 6e-11 | rs2079562 | 1 | GCST90565843 | no MR -> candidate analysis |
| Body size or adipose distribution (multivariate analysis) | 2e-10 | rs1990224 | 1 | GCST90624105 | no MR -> candidate analysis |
| Systolic blood pressure | 1e-8 | rs73053451 | 1 | GCST90662908 | MR: beta=0.0219, p=0.0789 (trans) |
| Gut microbiome abundance (class Clostridium sensu stricto sp | 2e-8 | rs55657832 | 1 | GCST90569106 | no MR -> candidate analysis |
| Physical function (baseline) | 4e-8 | rs2079562 | 1 | GCST90565837 | no MR -> candidate analysis |
| VCAM-1 levels in metastatic colorectal cancer | 4e-7 | rs6945041 | 2 | GCST90651094 | no MR -> candidate analysis |
| Adolescent idiopathic scoliosis | 6e-7 | rs17166189 | 1 | GCST006287 | no MR -> candidate analysis |
| TSP2 levels in metastatic colorectal cancer | 9e-7 | rs6945041 | 1 | GCST90651093 | no MR -> candidate analysis |
| Vitamin D deficiency | 1e-6 | rs557084736 | 1 | GCST90667552 | no MR -> candidate analysis |
| S-6-hydroxywarfarin levels | 1e-6 | rs116234739 | 1 | GCST90129565 | no MR -> candidate analysis |
| …and 9 more traits (see JSON) |
Top diseases by Open Targets association (of 135 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| colorectal carcinoma | 0.422 | — | common-variant locus | no MR -> candidate analysis |
| sweat gland disorder | 0.422 | — | common-variant locus | no MR -> candidate analysis |
| Alzheimer disease | 0.235 | — | common-variant locus | no MR -> candidate analysis |
| endocrine gland neoplasm | 0.121 | — | common-variant locus | no MR -> candidate analysis |
| pathological myopia | 0.082 | — | common-variant locus | no MR -> candidate analysis |
| hair morphology | 0.078 | — | common-variant locus | no MR -> candidate analysis |
| arthropathy | 0.077 | — | common-variant locus | no MR -> candidate analysis |
| bone neoplasm | 0.072 | — | common-variant locus | no MR -> candidate analysis |
| connective tissue neoplasm | 0.072 | — | common-variant locus | no MR -> candidate analysis |
| Graves disease | 0.067 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.062 | — | common-variant locus | no MR -> candidate analysis |
| protozoa infectious disease | 0.055 | — | common-variant locus | no MR -> candidate analysis |
| seasonal allergic rhinitis | 0.054 | — | common-variant locus | no MR -> candidate analysis |
| primary thrombocytopenia | 0.054 | — | common-variant locus | no MR -> candidate analysis |
| diverticular disease | 0.051 | — | common-variant locus | MR: beta=0.148, p=0.139 (trans) |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=4.4e-31, LOEUF=1.18 — LoF-tolerant |
| GWAS Catalog | 41 unique SNPs / 82 rows |
| ClinVar | 210 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 135 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘SCIN’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 210 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 21 traits by best p-value, aggregated from 31 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9Y6U3 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000006747/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/SCIN — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SCIN — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SCIN%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SCIN — GWAS Catalog search API (live; release not exposed)