Protein Dossier — SELL (L-selectin)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Autism |
0.207 |
0.0625 |
9.33e-04 |
Wald ratio |
1 |
cis |
NA |
| Lung adenocarcinoma |
0.135 |
0.0561 |
0.0161 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K43 Ventral hernia |
-0.236 |
0.101 |
0.0192 |
Wald ratio |
1 |
cis |
NA |
| Femoral neck bone mineral density |
-0.0377 |
0.0164 |
0.0212 |
Wald ratio |
1 |
cis |
NA |
| Lung cancer |
0.0866 |
0.0379 |
0.0223 |
Wald ratio |
1 |
cis |
NA |
| Squamous cell lung cancer |
0.129 |
0.0568 |
0.0227 |
Wald ratio |
1 |
cis |
NA |
| Childhood intelligence |
-0.0639 |
0.0283 |
0.0238 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: D12 Benign neoplasm of colon rectum anus and anal canal |
0.0906 |
0.0404 |
0.025 |
Wald ratio |
1 |
cis |
NA |
| Anorexia nervosa |
-0.147 |
0.069 |
0.0329 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms |
0.08 |
0.0394 |
0.0421 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities |
-0.0803 |
0.0397 |
0.0428 |
Wald ratio |
1 |
cis |
NA |
| Neo-neuroticism |
-0.408 |
0.208 |
0.05 |
Wald ratio |
1 |
cis |
NA |
| …and 87 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4831_4_2 |
sL-Selectin |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
45 association rows across 32 traits (39 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| L-selectin levels |
2e-363 |
rs4140655 |
10 |
GCST90248341 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein SELL levels |
6e-134 |
rs4987369 |
1 |
GCST90944888 |
no MR -> candidate analysis |
| L-Selectin levels (SELL.4831.4.2) |
7e-87 |
rs4987358 |
1 |
GCST90241725 |
no MR -> candidate analysis |
| Serum levels of protein SELL |
2e-82 |
rs4987358 |
1 |
GCST90088779 |
no MR -> candidate analysis |
| SELL protein levels |
8e-56 |
rs2223286 |
2 |
GCST90453181 |
no MR -> candidate analysis |
| ICAM2/SELE protein level ratio |
3e-53 |
rs2298900 |
1 |
GCST90315120 |
no MR -> candidate analysis |
| PTPRM/SELE protein level ratio |
2e-52 |
rs2298900 |
1 |
GCST90315753 |
no MR -> candidate analysis |
| ICAM1/SELE protein level ratio |
5e-52 |
rs2298900 |
1 |
GCST90315116 |
no MR -> candidate analysis |
| CD62L on monocyte |
4e-50 |
rs4987369 |
1 |
GCST90001834 |
no MR -> candidate analysis |
| Blood protein levels |
6e-48 |
rs4987358 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
2e-31 |
rs4987353 |
1 |
GCST90838671 |
no MR -> candidate analysis |
| ITGA5/SELE protein level ratio |
3e-30 |
rs4987318 |
1 |
GCST90315205 |
no MR -> candidate analysis |
| …and 20 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 900 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| type 2 diabetes mellitus |
0.565 |
— |
common-variant locus |
no MR -> candidate analysis |
| lymphatic system disorder |
0.512 |
— |
common-variant locus |
no MR -> candidate analysis |
| ankylosing spondylitis |
0.394 |
— |
common-variant locus |
MR: beta=0.133, p=0.13 (cis) |
| phlebitis |
0.369 |
— |
common-variant locus |
no MR -> candidate analysis |
| Thrombophlebitis |
0.369 |
— |
common-variant locus |
no MR -> candidate analysis |
| atrial fibrillation |
0.275 |
— |
common-variant locus |
MR: beta=0.0391, p=0.413 (cis) |
| aging |
0.174 |
— |
common-variant locus |
no MR -> candidate analysis |
| Sepsis |
0.035 |
— |
common-variant locus |
no MR -> candidate analysis |
| deep vein thrombosis |
0.141 |
— |
common-variant locus |
no MR -> candidate analysis |
| thrombophilia |
0.139 |
— |
common-variant locus |
no MR -> candidate analysis |
| venous thromboembolism |
0.133 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 11 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
2 known modulators (L-selectin) |
| gnomAD constraint |
pLI=1e-12, LOEUF=1.07 — LoF-tolerant |
| GWAS Catalog |
101 unique SNPs / 208 rows |
| ClinVar |
85 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 900 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘SELL’ and resolved to ‘L-selectin’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 85 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 32 traits by best p-value, aggregated from 45 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P14151 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000188404/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3161/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/SELL — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SELL — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SELL%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SELL — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:57:28 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none