Protein Dossier — SELP (P-selectin)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Height |
-0.0136 |
0.00657 |
0.0379 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Wrist |
-0.00121 |
0.000681 |
0.0763 |
Inverse variance weighted |
2 |
trans |
NA |
| Fractured bone site(s): Wrist |
-0.00121 |
0.000681 |
0.0763 |
Inverse variance weighted |
2 |
cis |
NA |
| Serum creatinine (eGFRcrea) |
0.00347 |
0.00198 |
0.0801 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
-0.00109 |
0.000638 |
0.0862 |
Inverse variance weighted |
2 |
trans |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
-0.00109 |
0.000638 |
0.0862 |
Inverse variance weighted |
2 |
cis |
NA |
| Non-cancer illness code self-reported: emphysema or chronic bronchitis |
-0.000882 |
0.000519 |
0.0891 |
Inverse variance weighted |
2 |
trans |
NA |
| Non-cancer illness code self-reported: emphysema or chronic bronchitis |
-0.000882 |
0.000519 |
0.0891 |
Inverse variance weighted |
2 |
cis |
NA |
| Hippocampus volume |
16.7 |
9.96 |
0.0939 |
Inverse variance weighted |
2 |
trans |
NA |
| Hippocampus volume |
16.7 |
9.96 |
0.0939 |
Inverse variance weighted |
2 |
cis |
NA |
| Diastolic blood pressure automated reading |
-0.00749 |
0.00453 |
0.0984 |
Inverse variance weighted |
2 |
trans |
NA |
| Diastolic blood pressure automated reading |
-0.00749 |
0.00453 |
0.0984 |
Inverse variance weighted |
2 |
cis |
NA |
| …and 135 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4154_57_2 |
P-Selectin |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
112 association rows across 83 traits (68 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating SELP levels |
2e-806 |
rs6136 |
4 |
GCST90859923 |
no MR -> candidate analysis |
| SELP/VSIR protein level ratio |
7e-662 |
rs6136 |
1 |
GCST90315822 |
no MR -> candidate analysis |
| GP1BA/SELP protein level ratio |
3e-541 |
rs6136 |
1 |
GCST90314958 |
no MR -> candidate analysis |
| CD46/SELP protein level ratio |
1e-532 |
rs6136 |
1 |
GCST90313834 |
no MR -> candidate analysis |
| SDC4/SELP protein level ratio |
4e-437 |
rs6136 |
1 |
GCST90315817 |
no MR -> candidate analysis |
| ITGB1/SELP protein level ratio |
1e-385 |
rs6136 |
1 |
GCST90315230 |
no MR -> candidate analysis |
| Bone mineral density mean |
1e-300 |
rs140704427 |
2 |
GCST90321120 |
no MR -> candidate analysis |
| SELL protein levels |
1e-295 |
rs3917775 |
4 |
GCST90470567 |
no MR -> candidate analysis |
| Blood protein levels |
2e-184 |
rs6136 |
2 |
GCST006585 |
no MR -> candidate analysis |
| Serum levels of protein SELP |
5e-162 |
rs6128 |
2 |
GCST90088610 |
no MR -> candidate analysis |
| L-selectin levels |
9e-118 |
rs3917775 |
3 |
GCST90248341 |
no MR -> candidate analysis |
| P-selectin levels (SELP.4154.57.2) |
3e-105 |
rs6136 |
2 |
GCST90242187 |
no MR -> candidate analysis |
| …and 71 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1435 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| atrial fibrillation |
0.542 |
— |
common-variant locus |
MR: beta=-0.000456, p=0.336 (trans) |
| deep vein thrombosis |
0.487 |
— |
common-variant locus |
no MR -> candidate analysis |
| aging |
0.524 |
— |
common-variant locus |
no MR -> candidate analysis |
| Abnormality of the skeletal system |
0.522 |
— |
common-variant locus |
no MR -> candidate analysis |
| thrombophilia |
0.493 |
— |
common-variant locus |
no MR -> candidate analysis |
| Thromboembolism |
0.481 |
— |
common-variant locus |
no MR -> candidate analysis |
| Premature coronary artery atherosclerosis |
0.426 |
— |
established (curated) |
no MR -> candidate analysis |
| viral pneumonia |
0.414 |
— |
common-variant locus |
no MR -> candidate analysis |
| acne |
0.138 |
— |
common-variant locus |
no MR -> candidate analysis |
| cancer |
0.078 |
— |
common-variant locus |
MR: beta=-0.000882, p=0.0891 (trans) |
Of the 10 rows above, 8 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
4 known modulators (P-selectin) |
| gnomAD constraint |
pLI=8.7e-28, LOEUF=1.05 — LoF-tolerant |
| GWAS Catalog |
137 unique SNPs / 366 rows |
| ClinVar |
162 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1435 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘SELP’ and resolved to ‘P-selectin’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 162 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 83 traits by best p-value, aggregated from 112 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P16109 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000174175/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL5378/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/SELP — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SELP — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SELP%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SELP — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:57:46 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none