Protein Dossier — SIGLEC6 (Sialic acid-binding Ig-like lectin 6)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Rheumatoid arthritis |
0.0747 |
0.0187 |
6.43e-05 |
Wald ratio |
1 |
cis |
NA |
| HbA1C |
0.0161 |
0.00521 |
0.00201 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: bone disorder |
0.188 |
0.0666 |
0.00484 |
Wald ratio |
1 |
cis |
NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
0.0473 |
0.0176 |
0.00721 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: depression |
-0.0354 |
0.016 |
0.0271 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M54 Dorsalgia |
0.059 |
0.0274 |
0.0316 |
Wald ratio |
1 |
cis |
NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
0.0205 |
0.00965 |
0.0334 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: pneumothorax |
0.276 |
0.143 |
0.0526 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level |
0.155 |
0.081 |
0.0563 |
Wald ratio |
1 |
cis |
NA |
| Fasting proinsulin |
-0.0199 |
0.0109 |
0.0671 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: uterine fibroids |
-0.0574 |
0.0321 |
0.0735 |
Wald ratio |
1 |
cis |
NA |
| Red blood cell count |
0.00597 |
0.00337 |
0.0763 |
Wald ratio |
1 |
cis |
NA |
| …and 98 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2741_22_2 |
Siglec-6 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
55 association rows across 20 traits (50 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating SIGLEC6 levels |
3e-880 |
rs62617068 |
9 |
GCST90860512 |
no MR -> candidate analysis |
| Sialic acid-binding Ig-like lectin 6 levels |
8e-533 |
rs4146202 |
11 |
GCST90249550 |
no MR -> candidate analysis |
| SIGLEC6 protein levels |
8e-252 |
rs180865472 |
7 |
GCST90470634 |
no MR -> candidate analysis |
| Serum levels of protein SIGLEC6 |
1e-210 |
rs12460678 |
2 |
GCST90088041 |
no MR -> candidate analysis |
| Sialic acid-binding Ig-like lectin 5 levels |
6e-150 |
rs140056884 |
2 |
GCST90249549 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein SIGLEC6 levels |
6e-119 |
rs79864857 |
1 |
GCST90943899 |
no MR -> candidate analysis |
| Blood protein levels |
1e-114 |
rs2305771 |
2 |
GCST006585 |
no MR -> candidate analysis |
| SIGLEC5 protein levels |
6e-77 |
rs736574 |
5 |
GCST90470633 |
no MR -> candidate analysis |
| Serum levels of protein SIGLEC14 |
2e-46 |
rs140056884 |
1 |
GCST90088943 |
no MR -> candidate analysis |
| SIGLEC8 protein levels |
7e-28 |
rs10401247 |
4 |
GCST90470636 |
no MR -> candidate analysis |
| Protein quantitative trait loci |
4e-22 |
rs10221508 |
1 |
GCST010900 |
no MR -> candidate analysis |
| Sialic acid-binding Ig-like lectin 14 levels |
2e-15 |
rs56109198 |
1 |
GCST90162313 |
no MR -> candidate analysis |
| …and 8 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 209 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Splenomegaly |
0.213 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1.4e-08, LOEUF=1.01 — LoF-tolerant |
| GWAS Catalog |
107 unique SNPs / 252 rows |
| ClinVar |
93 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 209 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘SIGLEC6’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 93 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 20 traits by best p-value, aggregated from 55 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/O43699 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000105492/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/SIGLEC6 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SIGLEC6 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SIGLEC6%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SIGLEC6 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:05:56 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none