Protein Dossier — SIGLEC9 (Sialic acid-binding Ig-like lectin 9)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Weight |
-0.00702 |
0.00174 |
5.55e-05 |
Wald ratio |
1 |
cis |
NA |
| Body mass index (BMI) |
-0.00739 |
0.00197 |
1.75e-04 |
Wald ratio |
1 |
cis |
NA |
| Amyotrophic lateral sclerosis |
0.0441 |
0.0145 |
0.00237 |
Wald ratio |
1 |
cis |
NA |
| High grade serous ovarian cancer |
-0.0379 |
0.013 |
0.00354 |
Wald ratio |
1 |
cis |
NA |
| Neo-extraversion |
-0.178 |
0.0641 |
0.0055 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: pneumothorax |
0.214 |
0.0784 |
0.00636 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema |
-0.0245 |
0.00898 |
0.00642 |
Wald ratio |
1 |
cis |
NA |
| Microalbuminuria |
-0.0449 |
0.018 |
0.0124 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: prostate cancer |
-0.0596 |
0.0245 |
0.0149 |
Wald ratio |
1 |
cis |
NA |
| Squamous cell lung cancer |
-0.0515 |
0.0212 |
0.0152 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: chronic obstructive airways disease or copd |
-0.0885 |
0.0369 |
0.0166 |
Wald ratio |
1 |
cis |
NA |
| Iron |
-0.0195 |
0.00816 |
0.0168 |
Wald ratio |
1 |
cis |
NA |
| …and 100 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3007_7_2 |
Siglec-9 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
89 association rows across 45 traits (87 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Sialic acid-binding Ig-like lectin 9 levels |
2e-5041 |
rs2075803 |
11 |
GCST90249553 |
no MR -> candidate analysis |
| Circulating SIGLEC9 levels |
3e-2701 |
rs2075803 |
6 |
GCST90859658 |
no MR -> candidate analysis |
| Sialic acid-binding Ig-like lectin 9 levels (SIGLEC9.3007.7. |
6e-2142 |
rs2075803 |
2 |
GCST90242813 |
no MR -> candidate analysis |
| Blood protein levels |
2e-723 |
rs1039405 |
3 |
GCST006585 |
no MR -> candidate analysis |
| Sialic acid-binding Ig-like lectin 7 levels |
6e-420 |
rs12983058 |
9 |
GCST90425443 |
no MR -> candidate analysis |
| Uromodulin levels |
3e-342 |
rs2075803 |
2 |
GCST90427813 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein SIGLEC7 levels |
2e-319 |
rs12983058 |
1 |
GCST90944577 |
no MR -> candidate analysis |
| Circulating SIGLEC7 levels |
6e-310 |
rs12983058 |
3 |
GCST90860368 |
no MR -> candidate analysis |
| SIGLEC7 protein levels |
3e-298 |
rs12983058 |
4 |
GCST90470635 |
no MR -> candidate analysis |
| Serum uromodulin levels (aptamer-based assay) |
2e-280 |
rs2075803 |
1 |
GCST90129632 |
no MR -> candidate analysis |
| Serum levels of protein UMOD |
3e-223 |
rs2075803 |
1 |
GCST90090697 |
no MR -> candidate analysis |
| Protein quantitative trait loci |
5e-208 |
rs2075803 |
1 |
GCST010900 |
no MR -> candidate analysis |
| …and 33 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 102 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| obesity disorder |
0.24 |
— |
common-variant locus |
no MR -> candidate analysis |
| arthropathy |
0.101 |
— |
common-variant locus |
no MR -> candidate analysis |
| osteoarthritis, knee |
0.061 |
— |
common-variant locus |
MR: beta=0.0165, p=0.438 (cis) |
Of the 3 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Sialic acid-binding Ig-like lectin 9) |
| gnomAD constraint |
pLI=1.4e-06, LOEUF=0.942 — LoF-tolerant |
| GWAS Catalog |
174 unique SNPs / 443 rows |
| ClinVar |
85 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 102 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘SIGLEC9’ and resolved to ‘Sialic acid-binding Ig-like lectin 9’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 85 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 45 traits by best p-value, aggregated from 89 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9Y336 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000129450/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4105860/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/SIGLEC9 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SIGLEC9 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SIGLEC9%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SIGLEC9 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:06:43 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none