MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Sodium in urine | -0.00648 | 0.00201 | 0.00129 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M72 Fibroblastic disorders | -0.0967 | 0.0307 | 0.00162 | Wald ratio | 1 | cis | NA |
| Cough on most days | -0.0333 | 0.0108 | 0.0021 | Wald ratio | 1 | cis | NA |
| Schizophrenia | -0.0274 | 0.00925 | 0.00304 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I30 Acute pericarditis | 0.261 | 0.0906 | 0.00399 | Wald ratio | 1 | cis | NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0302 | 0.0107 | 0.00455 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | -0.0409 | 0.0149 | 0.00601 | Wald ratio | 1 | cis | NA |
| Weight | -0.00482 | 0.00181 | 0.00769 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | -0.00781 | 0.00302 | 0.00985 | Wald ratio | 1 | cis | NA |
| Happiness | 0.00619 | 0.00254 | 0.0148 | Wald ratio | 1 | cis | NA |
| Pulse rate | -0.00853 | 0.00362 | 0.0183 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | -0.00406 | 0.00177 | 0.0218 | Wald ratio | 1 | cis | NA |
| …and 64 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
229 association rows across 83 traits (213 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating SIRPA levels | 1e-10333 | rs6136377 | 6 | GCST90859973 | no MR -> candidate analysis |
| Tyrosine-protein phosphatase non-receptor type substrate 1 l | 1e-5100 | rs1569960 | 17 | GCST90250037 | no MR -> candidate analysis |
| Tyrosine-protein phosphatase non-receptor type substrate 1 l | 8e-1361 | rs6136377 | 2 | GCST90243222 | no MR -> candidate analysis |
| Blood protein levels | 2e-1072 | rs6075340 | 1 | GCST006585 | no MR -> candidate analysis |
| Cerebrospinal fluid protein SIRPA levels | 1e-698 | rs4813331 | 1 | GCST90944895 | no MR -> candidate analysis |
| Tyrosine-protein phosphatase non-receptor type substrate 1 ( | 1e-310 | rs6075339 | 1 | GCST90426344 | no MR -> candidate analysis |
| Mean platelet thrombocyte volume (UKB data field 30100) | 2e-304 | rs4814779 | 6 | GCST90468087 | no MR -> candidate analysis |
| Mean platelet volume | 2e-264 | rs4814776 | 13 | GCST90002346 | no MR -> candidate analysis |
| Tyrosine-protein phosphatase non-receptor type substrate 1 l | 2e-263 | rs6075340 | 1 | GCST90237933 | no MR -> candidate analysis |
| Platelet crit (UKB data field 30090) | 1e-250 | rs11906768 | 4 | GCST90468096 | no MR -> candidate analysis |
| SIRPA protein levels | 2e-237 | rs77985164 | 32 | GCST90470639 | no MR -> candidate analysis |
| mean platelet volume (MPV, mean, inv-norm transformed) | 3e-134 | rs6136492 | 2 | GCST90479708 | no MR -> candidate analysis |
| …and 71 more traits (see JSON) |
Top diseases by Open Targets association (of 731 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| type 2 diabetes mellitus | 0.692 | — | common-variant locus | no MR -> candidate analysis |
| diabetes mellitus | 0.561 | — | common-variant locus | no MR -> candidate analysis |
| thrombocytopenia 4 | 0.554 | — | common-variant locus | no MR -> candidate analysis |
| hemorrhagic disease | 0.559 | — | common-variant locus | no MR -> candidate analysis |
| tooth disorder | 0.545 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.404 | — | common-variant locus | no MR -> candidate analysis |
| urolithiasis | 0.347 | — | common-variant locus | no MR -> candidate analysis |
Of the 7 rows above, 7 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1, LOEUF=0.312 — LoF-INTOLERANT |
| GWAS Catalog | 140 unique SNPs / 327 rows |
| ClinVar | 133 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 731 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘SIRPA’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 133 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 83 traits by best p-value, aggregated from 229 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P78324 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000198053/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/SIRPA — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SIRPA — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SIRPA%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SIRPA — GWAS Catalog search API (live; release not exposed)