MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: R55 Syncope and collapse | 0.279 | 0.0775 | 3.21e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: anxiety or panic attacks | 0.232 | 0.0658 | 4.25e-04 | Wald ratio | 1 | cis | NA |
| Ulcerative colitis | -0.128 | 0.0521 | 0.0138 | Wald ratio | 1 | cis | NA |
| Low grade serous ovarian cancer | 0.476 | 0.194 | 0.0142 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R35 Polyuria | 0.284 | 0.117 | 0.0155 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K80 Cholelithiasis | 0.14 | 0.0582 | 0.0162 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypopituitarism | 0.676 | 0.293 | 0.0209 | Wald ratio | 1 | cis | NA |
| Schizophrenia | -0.0989 | 0.043 | 0.0214 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: vaginal prolapse or uterine prolapse | 0.231 | 0.104 | 0.0269 | Wald ratio | 1 | cis | NA |
| Fasting insulin | -0.0282 | 0.0129 | 0.0295 | Wald ratio | 1 | cis | NA |
| Ferritin | -0.0814 | 0.0377 | 0.0306 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: C50 Malignant neoplasm of breast | -0.183 | 0.0909 | 0.0439 | Wald ratio | 1 | cis | NA |
| …and 94 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
45 association rows across 35 traits (40 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| LTBR/SIRPB1 protein level ratio | 2e-2930 | rs76958425 | 1 | GCST90315339 | no MR -> candidate analysis |
| OSCAR/SIRPB1 protein level ratio | 6e-2733 | rs76958425 | 1 | GCST90315587 | no MR -> candidate analysis |
| Circulating SIRPB1 levels | 3e-2444 | rs75649571 | 1 | GCST90860614 | no MR -> candidate analysis |
| CD58/SIRPB1 protein level ratio | 2e-2380 | rs76958425 | 1 | GCST90313855 | no MR -> candidate analysis |
| Blood protein levels | 5e-226 | rs4814391 | 2 | GCST006585 | no MR -> candidate analysis |
| Mean platelet thrombocyte volume (UKB data field 30100) | 5e-191 | rs11696739 | 1 | GCST90468087 | no MR -> candidate analysis |
| SIRPB1 protein levels | 1e-190 | rs62186952 | 4 | GCST90470640 | no MR -> candidate analysis |
| Signal-regulatory protein beta-1 levels (SIRPB1.6247.9.3) | 3e-161 | rs76357893 | 1 | GCST90242820 | no MR -> candidate analysis |
| Signal-regulatory protein gamma levels | 4e-132 | rs6043409 | 1 | GCST90249560 | no MR -> candidate analysis |
| Signal-regulatory protein beta-1 levels | 2e-105 | rs2277760 | 1 | GCST90249559 | no MR -> candidate analysis |
| Mean platelet volume | 3e-100 | rs11696739 | 2 | GCST90002395 | no MR -> candidate analysis |
| Immature platelet count | 1e-37 | rs56078965 | 1 | GCST90281199 | no MR -> candidate analysis |
| …and 23 more traits (see JSON) |
Top diseases by Open Targets association (of 311 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| type 1 diabetes mellitus | 0.842 | — | common-variant locus | no MR -> candidate analysis |
| rheumatoid arthritis | 0.522 | — | common-variant locus | MR: beta=0.116, p=0.0536 (cis) |
| alcohol drinking | 0.519 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.287 | — | common-variant locus | no MR -> candidate analysis |
| tooth disorder | 0.254 | — | common-variant locus | no MR -> candidate analysis |
| placental retention | 0.249 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.243 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.243 | — | common-variant locus | no MR -> candidate analysis |
| narcolepsy-cataplexy syndrome | 0.239 | — | common-variant locus | no MR -> candidate analysis |
| spermatogenic failure | 0.206 | — | common-variant locus | no MR -> candidate analysis |
Of the 10 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=3.1e-14, LOEUF=1.4 — LoF-tolerant |
| GWAS Catalog | 95 unique SNPs / 184 rows |
| ClinVar | 123 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 311 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘SIRPG’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 123 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 35 traits by best p-value, aggregated from 45 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9P1W8 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000089012/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/SIRPG — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SIRPG — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SIRPG%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SIRPG — GWAS Catalog search API (live; release not exposed)