Protein Dossier — SLAMF7 (SLAM family member 7)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Ulcerative colitis |
0.0621 |
0.0157 |
7.35e-05 |
Wald ratio |
1 |
cis |
NA |
| Multiple sclerosis |
0.0633 |
0.0196 |
0.00126 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: bladder problem (not cancer) |
-0.109 |
0.0416 |
0.00893 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
0.00588 |
0.00233 |
0.0116 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: depression |
0.0282 |
0.0114 |
0.0133 |
Wald ratio |
1 |
cis |
NA |
| Inflammatory bowel disease |
0.0284 |
0.0123 |
0.0206 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: vaginal prolapse or uterine prolapse |
-0.0933 |
0.0423 |
0.0275 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: mania or bipolar disorder or manic depression |
-0.131 |
0.0637 |
0.0402 |
Wald ratio |
1 |
cis |
NA |
| Pulse rate |
-0.00994 |
0.00501 |
0.0472 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertrophic cardiomyopathy (hcm or hocm) |
0.295 |
0.152 |
0.0523 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis |
0.0584 |
0.0311 |
0.0606 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R55 Syncope and collapse |
-0.0553 |
0.0319 |
0.0827 |
Wald ratio |
1 |
cis |
NA |
| …and 50 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5487_7_3 |
SLAF7 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
82 association rows across 38 traits (79 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating SLAMF7 levels |
2e-3149 |
rs11581248 |
8 |
GCST90859745 |
no MR -> candidate analysis |
| ICAM3/SLAMF7 protein level ratio |
3e-1976 |
rs11265473 |
1 |
GCST90315123 |
no MR -> candidate analysis |
| LY96/SLAMF7 protein level ratio |
5e-1884 |
rs11265473 |
1 |
GCST90315347 |
no MR -> candidate analysis |
| CD48/SLAMF7 protein level ratio |
7e-1715 |
rs11265473 |
1 |
GCST90313842 |
no MR -> candidate analysis |
| SLAMF7/TXNDC15 protein level ratio |
2e-1641 |
rs11265473 |
1 |
GCST90315850 |
no MR -> candidate analysis |
| Circulating LY9 levels |
2e-1425 |
rs12405457 |
1 |
GCST90860013 |
no MR -> candidate analysis |
| SLAM family member 7 levels |
2e-1362 |
rs11581248 |
12 |
GCST90249565 |
no MR -> candidate analysis |
| ICAM3/LY9 protein level ratio |
4e-781 |
rs535241 |
1 |
GCST90315121 |
no MR -> candidate analysis |
| Circulating CD48 levels |
3e-534 |
rs352684 |
1 |
GCST90860011 |
no MR -> candidate analysis |
| SLAM family member 7 levels (SLAMF7.5487.7.3) |
2e-397 |
rs11581248 |
2 |
GCST90242832 |
no MR -> candidate analysis |
| SLAM family member 7 (analyte X5487.7) levels |
9e-213 |
rs11581248 |
1 |
GCST90426368 |
no MR -> candidate analysis |
| Blood protein levels |
4e-208 |
rs11581248 |
1 |
GCST006585 |
no MR -> candidate analysis |
| …and 26 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 257 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| multiple sclerosis |
0.57 |
— |
common-variant locus |
MR: beta=0.0633, p=0.00126 (cis) |
| Epstein-Barr virus infection |
0.532 |
— |
common-variant locus |
no MR -> candidate analysis |
| rotator cuff syndrome |
0.459 |
— |
common-variant locus |
no MR -> candidate analysis |
| Delayed puberty |
0.36 |
— |
common-variant locus |
no MR -> candidate analysis |
| autism |
0.182 |
— |
established (curated) |
no MR -> candidate analysis |
Of the 5 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
2 known modulators (SLAM family member 7) |
| gnomAD constraint |
pLI=1.6e-07, LOEUF=1.06 — LoF-tolerant |
| GWAS Catalog |
120 unique SNPs / 296 rows |
| ClinVar |
47 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 257 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘SLAMF7’ and resolved to ‘SLAM family member 7’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 47 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 38 traits by best p-value, aggregated from 82 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9NQ25 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000026751/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3559386/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/SLAMF7 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SLAMF7 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SLAMF7%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SLAMF7 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:08:14 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none