MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: high cholesterol | 0.0885 | 0.0337 | 0.0086 | Wald ratio | 1 | trans | NA |
| Clear cell ovarian cancer | 0.48 | 0.231 | 0.0376 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: hypopituitarism | 0.803 | 0.393 | 0.041 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: J33 Nasal polyp | 0.3 | 0.15 | 0.0461 | Wald ratio | 1 | trans | NA |
| Forced vital capacity (FVC) | -0.022 | 0.0112 | 0.0487 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] | 0.164 | 0.0837 | 0.0497 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: kidney stone or ureter stone or bladder stone | 0.235 | 0.124 | 0.0578 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: polio or poliomyelitis | 0.592 | 0.324 | 0.0678 | Wald ratio | 1 | trans | NA |
| Creatinine (enzymatic) in urine | 0.0229 | 0.013 | 0.0782 | Wald ratio | 1 | trans | NA |
| Cigarettes smoked per day | 0.856 | 0.49 | 0.081 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: M23 Internal derangement of knee | 0.139 | 0.0801 | 0.0819 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: D12 Benign neoplasm of colon rectum anus and anal canal | 0.17 | 0.098 | 0.0836 | Wald ratio | 1 | trans | NA |
| …and 79 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
184 association rows across 106 traits (166 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Arachidonoylcarnitine (C20:4) levels | 6e-174 | rs12210538 | 2 | GCST90200150 | no MR -> candidate analysis |
| Dihomo-linolenoylcarnitine (C20:3n3 or 6) levels | 2e-164 | rs12210538 | 2 | GCST90200139 | no MR -> candidate analysis |
| Linoleoylcarnitine levels | 2e-156 | rs72939920 | 2 | GCST90245282 | no MR -> candidate analysis |
| Octadecandienylcarnitine levels | 2e-144 | rs12210538 | 1 | GCST90010774 | no MR -> candidate analysis |
| Oleoylcarnitine levels | 1e-132 | rs72939920 | 2 | GCST90245349 | no MR -> candidate analysis |
| Acylcarnitine (18:1) levels | 6e-97 | rs12210538 | 9 | GCST90024622 | no MR -> candidate analysis |
| Palmitoylcarnitine levels | 2e-89 | rs72939920 | 2 | GCST90245362 | no MR -> candidate analysis |
| Hexadecanoylcarnitine levels | 2e-82 | rs72939920 | 1 | GCST90010770 | no MR -> candidate analysis |
| Stearoylcarnitine levels | 1e-76 | rs72939920 | 2 | GCST90245435 | no MR -> candidate analysis |
| Acylcarnitine (16:0) levels | 1e-76 | rs12210538 | 8 | GCST90023988 | no MR -> candidate analysis |
| Dihomo-linoleoylcarnitine (C20:2) levels | 4e-72 | rs12210538 | 2 | GCST90200144 | no MR -> candidate analysis |
| Plasma arachidonoylcarnitine (C20:4) levels in chronic kidne | 3e-70 | rs12210538 | 1 | GCST90264823 | no MR -> candidate analysis |
| …and 94 more traits (see JSON) |
Top diseases by Open Targets association (of 85 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| melanoma | 0.582 | — | common-variant locus | MR: beta=-0.252, p=0.228 (trans) |
| cervical carcinoma | 0.479 | — | common-variant locus | no MR -> candidate analysis |
| ulcerative colitis | 0.44 | — | common-variant locus | no MR -> candidate analysis |
| cardiomyopathy | 0.406 | — | common-variant locus | no MR -> candidate analysis |
| endocrine system disorder | 0.23 | — | common-variant locus | no MR -> candidate analysis |
| ovarian dysfunction | 0.141 | — | common-variant locus | no MR -> candidate analysis |
| self-injurious ideation | 0.096 | — | common-variant locus | no MR -> candidate analysis |
| cellulitis | 0.09 | — | common-variant locus | MR: beta=-0.132, p=0.463 (trans) |
| abscess | 0.09 | — | common-variant locus | no MR -> candidate analysis |
Of the 9 rows above, 7 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Solute carrier family 22 member 16) |
| gnomAD constraint | pLI=1.5e-18, LOEUF=1.26 — LoF-tolerant |
| GWAS Catalog | 75 unique SNPs / 141 rows |
| ClinVar | 143 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | 5 clinical annotations across 4 drugs |
phenome — Top 30 of 85 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘SLC22A16’ and resolved to ‘Solute carrier family 22 member 16’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 143 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 106 traits by best p-value, aggregated from 184 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q86VW1 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000004809/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2073722/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/SLC22A16 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SLC22A16 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SLC22A16%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=SLC22A16 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/SLC22A16 — GWAS Catalog search API (live; release not exposed)