MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: hayfever or allergic rhinitis | 0.0938 | 0.0387 | 0.0155 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: malignant melanoma | 0.224 | 0.0946 | 0.0181 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | 0.0237 | 0.0103 | 0.0218 | Wald ratio | 1 | cis | NA |
| Pulse rate | 0.0397 | 0.0183 | 0.0306 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: prostate cancer | -0.37 | 0.182 | 0.0421 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb | -0.195 | 0.0965 | 0.0435 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | 0.0168 | 0.00848 | 0.0474 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: enlarged prostate | 0.151 | 0.0764 | 0.0477 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Injury or trauma resulting in loss of vision | 0.209 | 0.111 | 0.0601 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R04 Haemorrhage from respiratory passages | 0.22 | 0.117 | 0.0603 | Wald ratio | 1 | cis | NA |
| Primary sclerosing cholangitis | -0.276 | 0.151 | 0.0668 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | 0.0164 | 0.00894 | 0.067 | Wald ratio | 1 | cis | NA |
| …and 64 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
5 association rows across 5 traits (5 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| SLIT and NTRK-like protein 3 levels | 3e-143 | rs62282371 | 1 | GCST90249567 | no MR -> candidate analysis |
| SLIT and NTRK-like protein 3 levels (SLITRK3.10565.19.3) | 2e-49 | rs398062996 | 1 | GCST90242836 | no MR -> candidate analysis |
| Serum levels of protein SLITRK3 | 4e-31 | rs62282368 | 1 | GCST90086345 | no MR -> candidate analysis |
| Blood protein levels | 4e-19 | rs62282371 | 1 | GCST006585 | no MR -> candidate analysis |
| Eukaryotic translation initiation factor 2 subunit 2 protein | 6e-10 | rs62282368 | 1 | GCST90442203 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 67 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Intellectual disability | 0.547 | — | established (curated) | no MR -> candidate analysis |
| premature birth | 0.419 | — | common-variant locus | no MR -> candidate analysis |
| acquired polycythemia vera | 0.331 | — | common-variant locus | no MR -> candidate analysis |
| myeloproliferative disorder | 0.261 | — | common-variant locus | no MR -> candidate analysis |
| intracranial hemorrhage | 0.134 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.062 | — | common-variant locus | no MR -> candidate analysis |
| colon carcinoma | 0.054 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.054 | — | common-variant locus | no MR -> candidate analysis |
| vascular disorder | 0.054 | — | common-variant locus | no MR -> candidate analysis |
| intestinal disorder | 0.054 | — | common-variant locus | no MR -> candidate analysis |
| gastrointestinal disease | 0.054 | — | common-variant locus | no MR -> candidate analysis |
| diaphragm disorder | 0.053 | — | common-variant locus | no MR -> candidate analysis |
| drug allergy | 0.041 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the gastrointestinal tract | 0.034 | — | common-variant locus | no MR -> candidate analysis |
| neuropathy | 0.033 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1, LOEUF=0.382 — LoF-INTOLERANT |
| GWAS Catalog | 74 unique SNPs / 89 rows |
| ClinVar | 135 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 67 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘SLITRK3’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 135 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 5 of 5 traits by best p-value, aggregated from 5 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O94933 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000121871/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/SLITRK3 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SLITRK3 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SLITRK3%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SLITRK3 — GWAS Catalog search API (live; release not exposed)