Protein Dossier — SPARCL1 (SPARC-like protein 1)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms |
0.127 |
0.0327 |
1.01e-04 |
Inverse variance weighted |
2 |
cis |
NA |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms |
0.127 |
0.0327 |
1.01e-04 |
Inverse variance weighted |
2 |
trans |
NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities |
0.0813 |
0.0293 |
0.00555 |
Inverse variance weighted |
2 |
cis |
NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities |
0.0813 |
0.0293 |
0.00555 |
Inverse variance weighted |
2 |
trans |
NA |
| Clear cell ovarian cancer |
-0.208 |
0.0766 |
0.00653 |
Inverse variance weighted |
2 |
cis |
NA |
| Clear cell ovarian cancer |
-0.208 |
0.0766 |
0.00653 |
Inverse variance weighted |
2 |
trans |
NA |
| Hippocampus volume |
28.8 |
10.8 |
0.00785 |
Inverse variance weighted |
2 |
cis |
NA |
| Hippocampus volume |
28.8 |
10.8 |
0.00785 |
Inverse variance weighted |
2 |
trans |
NA |
| Ferritin |
0.04 |
0.0175 |
0.0223 |
Inverse variance weighted |
2 |
cis |
NA |
| Ferritin |
0.04 |
0.0175 |
0.0223 |
Inverse variance weighted |
2 |
trans |
NA |
| Cardioembolic stroke |
0.129 |
0.0588 |
0.0279 |
Inverse variance weighted |
2 |
cis |
NA |
| Cardioembolic stroke |
0.129 |
0.0588 |
0.0279 |
Inverse variance weighted |
2 |
trans |
NA |
| …and 163 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4467_49_2 |
SPARCL1 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
63 association rows across 30 traits (61 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating SPARCL1 levels |
8e-2786 |
rs4693826 |
3 |
GCST90860484 |
no MR -> candidate analysis |
| SPARC-like protein 1 levels |
1e-522 |
rs7671511 |
8 |
GCST90249613 |
no MR -> candidate analysis |
| SPARCL1 protein levels |
8e-227 |
rs112213305 |
18 |
GCST90470717 |
no MR -> candidate analysis |
| Serum levels of protein SPARCL1 |
5e-143 |
rs7681694 |
3 |
GCST90088700 |
no MR -> candidate analysis |
| SPARC-like protein 1 levels (SPARCL1.4467.49.2) |
3e-105 |
rs7681694 |
2 |
GCST90242870 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein SPARCL1 levels |
5e-83 |
rs62315960 |
1 |
GCST90945049 |
no MR -> candidate analysis |
| Blood protein levels |
1e-78 |
rs7681694 |
2 |
GCST006585 |
no MR -> candidate analysis |
| Height |
7e-30 |
rs10001608 |
1 |
GCST90245848 |
MR: beta=-0.0209, p=0.486 (cis) |
| Hematological traits (multi-trait analysis) |
5e-26 |
rs12644532 |
1 |
GCST90838669 |
no MR -> candidate analysis |
| SPARC-like protein 1 (analyte X13707.27) levels |
6e-26 |
rs17012853 |
1 |
GCST90422315 |
no MR -> candidate analysis |
| Urate levels |
6e-21 |
rs116183010 |
2 |
GCST90019524 |
no MR -> candidate analysis |
| SPARC-like protein 1 level in Chronic kidney disease with hy |
5e-20 |
rs1031795 |
1 |
GCST90237656 |
no MR -> candidate analysis |
| …and 18 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 280 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| gout |
0.75 |
— |
common-variant locus |
MR: beta=-0.0671, p=0.265 (cis) |
| congenital stromal corneal dystrophy |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
| Abnormality of the skeletal system |
0.589 |
— |
common-variant locus |
no MR -> candidate analysis |
| stromal corneal dystrophy |
0.547 |
— |
established (curated) |
no MR -> candidate analysis |
| spinal cord injury |
0.416 |
— |
common-variant locus |
no MR -> candidate analysis |
| coronary atherosclerosis |
0.157 |
— |
common-variant locus |
no MR -> candidate analysis |
| metabolic syndrome |
0.033 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 7 rows above, 6 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=3.3e-14, LOEUF=0.977 — LoF-tolerant |
| GWAS Catalog |
80 unique SNPs / 160 rows |
| ClinVar |
148 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 280 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘SPARCL1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 148 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 30 traits by best p-value, aggregated from 63 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q14515 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000152583/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/SPARCL1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SPARCL1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SPARCL1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SPARCL1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:10:58 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none