MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Pallidum volume | -31 | 10.7 | 0.00383 | Wald ratio | 1 | cis | NA |
| Forearm bone mineral density | 0.14 | 0.0649 | 0.0307 | Wald ratio | 1 | cis | NA |
| Creatinine (enzymatic) in urine | -0.0188 | 0.0087 | 0.0309 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N92 Excessive frequent and irregular menstruation | 0.116 | 0.0565 | 0.0402 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Injury or trauma resulting in loss of vision | 0.195 | 0.0984 | 0.0474 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.0176 | 0.00908 | 0.0531 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: high cholesterol | 0.0417 | 0.0236 | 0.0769 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Cataract | -0.0952 | 0.0547 | 0.0819 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine | 0.1 | 0.0581 | 0.085 | Wald ratio | 1 | cis | NA |
| Weight | -0.0134 | 0.00802 | 0.0939 | Wald ratio | 1 | cis | NA |
| Heel bone mineral density (BMD) T-score automated | -0.0193 | 0.0117 | 0.101 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: enlarged prostate | -0.147 | 0.0909 | 0.106 | Wald ratio | 1 | cis | NA |
| …and 54 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
61 association rows across 45 traits (32 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Serum levels of protein SPOCK3 | 1e-186 | rs62353586 | 4 | GCST90090901 | no MR -> candidate analysis |
| Testican-3 levels | 1e-152 | rs62353586 | 6 | GCST90249873 | no MR -> candidate analysis |
| Blood protein levels | 5e-96 | rs62353586 | 1 | GCST006585 | no MR -> candidate analysis |
| Testican-3 levels (SPOCK3.9906.21.3) | 2e-28 | rs17599599 | 2 | GCST90242988 | no MR -> candidate analysis |
| Testican-3 level in Chronic kidney disease with hypertension | 4e-17 | rs4385095 | 1 | GCST90239534 | no MR -> candidate analysis |
| GLIPR1 protein levels | 4e-12 | rs774502822 | 1 | GCST90469357 | no MR -> candidate analysis |
| Symptomatic extra- and intra-cranial atherosclerotic stenosi | 1e-11 | rs139225422 | 1 | GCST90319540 | no MR -> candidate analysis |
| Toxic multinodular goiter (PheCode 242.2) | 1e-11 | rs147778808 | 1 | GCST90479864 | no MR -> candidate analysis |
| DnaJ homolog subfamily B member 3 protein levels (SomaScan I | 2e-11 | rs35065151 | 1 | GCST90439025 | no MR -> candidate analysis |
| Adolescent idiopathic scoliosis | 2e-11 | rs6841675 | 1 | GCST006287 | no MR -> candidate analysis |
| Immune reponse to smallpox (secreted IL-10) | 3e-11 | rs13111850 | 1 | GCST001534 | no MR -> candidate analysis |
| Total PHF-tau (SNP x SNP interaction) | 1e-9 | rs17696409 x rs1419028 | 1 | GCST010340 | no MR -> candidate analysis |
| …and 33 more traits (see JSON) |
Top diseases by Open Targets association (of 164 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Hypercholesterolemia | 0.537 | — | common-variant locus | MR: beta=0.0417, p=0.0769 (cis) |
| medical procedure | 0.523 | — | common-variant locus | no MR -> candidate analysis |
| complication | 0.523 | — | common-variant locus | no MR -> candidate analysis |
| trauma complication | 0.523 | — | common-variant locus | no MR -> candidate analysis |
| response to antihypertensive drug | 0.519 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.506 | — | common-variant locus | no MR -> candidate analysis |
| liver disorder | 0.49 | — | common-variant locus | no MR -> candidate analysis |
| adolescent idiopathic scoliosis | 0.479 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.469 | — | common-variant locus | no MR -> candidate analysis |
| response to vaccine | 0.409 | — | common-variant locus | no MR -> candidate analysis |
| bone Paget disease | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| pericarditis | 0.393 | — | common-variant locus | no MR -> candidate analysis |
| tooth disorder | 0.388 | — | common-variant locus | no MR -> candidate analysis |
| alopecia areata | 0.382 | — | common-variant locus | no MR -> candidate analysis |
| congenital anomaly of cardiovascular system | 0.382 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.0001, LOEUF=0.719 — LoF-tolerant |
| GWAS Catalog | 66 unique SNPs / 119 rows |
| ClinVar | 130 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 164 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘SPOCK3’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 130 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 45 traits by best p-value, aggregated from 61 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9BQ16 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000196104/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/SPOCK3 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SPOCK3 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SPOCK3%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SPOCK3 — GWAS Catalog search API (live; release not exposed)