MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain | 0.133 | 0.0401 | 9.21e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: sleep apnoea | 0.355 | 0.122 | 0.00357 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | 0.0365 | 0.014 | 0.00921 | Wald ratio | 1 | cis | NA |
| Pulse rate | 0.0422 | 0.0167 | 0.0116 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Glaucoma | 0.159 | 0.0678 | 0.0189 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: malignant melanoma | 0.206 | 0.0883 | 0.0197 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis | 0.17 | 0.0761 | 0.0258 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest | -0.102 | 0.0469 | 0.0299 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level | 0.365 | 0.171 | 0.0328 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: basal cell carcinoma | -0.279 | 0.134 | 0.0368 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: bone disorder | 0.312 | 0.152 | 0.0406 | Wald ratio | 1 | cis | NA |
| Schizophrenia | 0.0825 | 0.0424 | 0.0517 | Wald ratio | 1 | cis | NA |
| …and 58 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
128 association rows across 88 traits (97 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating ST3GAL1 levels | 1e-313 | rs9643300 | 6 | GCST90860277 | no MR -> candidate analysis |
| Bone mineral density mean | 1e-300 | rs72720294 | 2 | GCST90321120 | no MR -> candidate analysis |
| Circulating LYPD3 levels | 3e-160 | rs7842080 | 2 | GCST90860022 | no MR -> candidate analysis |
| Circulating CCDC80 levels | 2e-133 | rs2142306 | 3 | GCST90860352 | no MR -> candidate analysis |
| Height | 1e-103 | rs4736702 | 8 | GCST90245848 | no MR -> candidate analysis |
| CCDC80 protein levels | 9e-103 | rs2142306 | 4 | GCST90468562 | no MR -> candidate analysis |
| CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialylt | 6e-65 | rs9643300 | 2 | GCST90247069 | no MR -> candidate analysis |
| VIT protein levels | 5e-64 | rs2142306 | 2 | GCST90471041 | no MR -> candidate analysis |
| SDC1 protein levels | 2e-48 | rs10101832 | 1 | GCST90470558 | no MR -> candidate analysis |
| SSC5D protein levels | 2e-47 | rs2142306 | 2 | GCST90470748 | no MR -> candidate analysis |
| Circulating SDC1 levels | 5e-46 | rs7827450 | 1 | GCST90860008 | no MR -> candidate analysis |
| ST3GAL1 protein levels | 2e-40 | rs6986303 | 2 | GCST90470752 | no MR -> candidate analysis |
| …and 76 more traits (see JSON) |
Top diseases by Open Targets association (of 172 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| prostate carcinoma | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.486 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.486 | — | common-variant locus | no MR -> candidate analysis |
| Hepatomegaly | 0.475 | — | common-variant locus | no MR -> candidate analysis |
| inner ear disorder | 0.444 | — | common-variant locus | no MR -> candidate analysis |
| Meniere disease | 0.409 | — | common-variant locus | no MR -> candidate analysis |
| hypothyroidism | 0.407 | — | common-variant locus | no MR -> candidate analysis |
| insomnia | 0.397 | — | common-variant locus | no MR -> candidate analysis |
| hepatitis B virus infection | 0.387 | — | common-variant locus | no MR -> candidate analysis |
| bone Paget disease | 0.387 | — | common-variant locus | no MR -> candidate analysis |
| fungal infectious disease | 0.387 | — | common-variant locus | no MR -> candidate analysis |
| psoriatic arthritis | 0.387 | — | common-variant locus | no MR -> candidate analysis |
| preeclampsia | 0.335 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.336 | — | common-variant locus | no MR -> candidate analysis |
| thyroid cancer | 0.336 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1) |
| gnomAD constraint | pLI=0.036, LOEUF=0.713 — LoF-tolerant |
| GWAS Catalog | 85 unique SNPs / 170 rows |
| ClinVar | 118 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 172 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘ST3GAL1’ and resolved to ‘CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 118 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 88 traits by best p-value, aggregated from 128 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q11201 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000008513/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3596074/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/ST3GAL1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ST3GAL1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ST3GAL1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ST3GAL1 — GWAS Catalog search API (live; release not exposed)