MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: R04 Haemorrhage from respiratory passages | 0.124 | 0.0361 | 5.94e-04 | Wald ratio | 1 | cis | NA |
| Age at menarche | -0.024 | 0.00728 | 1.00e-03 | Wald ratio | 1 | cis | NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0418 | 0.0141 | 0.00294 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M54 Dorsalgia | -0.0709 | 0.0245 | 0.00385 | Wald ratio | 1 | cis | NA |
| Height | -0.0101 | 0.00367 | 0.00589 | Wald ratio | 1 | cis | NA |
| Sleep duration | 0.00628 | 0.0023 | 0.00625 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: C61 Malignant neoplasm of prostate | -0.0992 | 0.0399 | 0.0129 | Wald ratio | 1 | cis | NA |
| Weight | -0.00645 | 0.0026 | 0.013 | Wald ratio | 1 | cis | NA |
| Large vessel disease | -0.104 | 0.0421 | 0.0138 | Wald ratio | 1 | cis | NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.0191 | 0.00777 | 0.0139 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M72 Fibroblastic disorders | 0.0873 | 0.0367 | 0.0175 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K29 Gastritis and duodenitis | -0.047 | 0.02 | 0.0185 | Wald ratio | 1 | cis | NA |
| …and 98 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
424 association rows across 291 traits (411 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating ICAM2 levels | 3e-4665 | rs10935473 | 3 | GCST90859991 | no MR -> candidate analysis |
| ENG/ICAM2 protein level ratio | 2e-3465 | rs10935473 | 1 | GCST90314646 | no MR -> candidate analysis |
| Circulating SIGLEC9 levels | 1e-3034 | rs10935473 | 4 | GCST90859658 | no MR -> candidate analysis |
| Circulating FLT4 levels | 1e-2869 | rs11927405 | 2 | GCST90860081 | no MR -> candidate analysis |
| EPHB4/ICAM2 protein level ratio | 3e-2779 | rs10935473 | 1 | GCST90314680 | no MR -> candidate analysis |
| Circulating PDCD1LG2 levels (id: OID00458_OID21273) | 4e-1895 | rs10935473 | 2 | GCST90859819 | no MR -> candidate analysis |
| Circulating PDCD1LG2 levels (id: OID00831_OID21273) | 2e-1444 | rs10935473 | 2 | GCST90860159 | no MR -> candidate analysis |
| Type 2 lactosamine alpha-2,3-sialyltransferase levels | 5e-1184 | rs72934623 | 2 | GCST90249754 | no MR -> candidate analysis |
| ICOSLG/PDCD1LG2 protein level ratio | 1e-1038 | rs10935473 | 1 | GCST90315125 | no MR -> candidate analysis |
| Circulating CD200R1 levels | 2e-646 | rs10935473 | 2 | GCST90859738 | no MR -> candidate analysis |
| Circulating IL1R1 levels | 3e-564 | rs10935473 | 1 | GCST90859959 | no MR -> candidate analysis |
| Serum uromodulin levels (aptamer-based assay) | 7e-442 | rs34211178 | 3 | GCST90129632 | no MR -> candidate analysis |
| …and 279 more traits (see JSON) |
Top diseases by Open Targets association (of 114 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Abnormality of the skeletal system | 0.797 | — | common-variant locus | no MR -> candidate analysis |
| hypothyroidism | 0.69 | — | common-variant locus | no MR -> candidate analysis |
| basal cell carcinoma | 0.643 | — | common-variant locus | MR: beta=-0.0258, p=0.414 (cis) |
| skin cancer | 0.559 | — | common-variant locus | no MR -> candidate analysis |
| skin neoplasm | 0.559 | — | common-variant locus | no MR -> candidate analysis |
| actinic keratosis | 0.554 | — | common-variant locus | no MR -> candidate analysis |
| post term pregnancy | 0.455 | — | common-variant locus | no MR -> candidate analysis |
| Hashimoto thyroiditis | 0.452 | — | common-variant locus | no MR -> candidate analysis |
| lichen planus | 0.451 | — | common-variant locus | no MR -> candidate analysis |
| skin disorder | 0.448 | — | common-variant locus | no MR -> candidate analysis |
| thyroid gland disorder | 0.443 | — | common-variant locus | no MR -> candidate analysis |
| protozoa infectious disease | 0.427 | — | common-variant locus | no MR -> candidate analysis |
| autoimmune disease | 0.348 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.108 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.102 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=8.7e-09, LOEUF=1.03 — LoF-tolerant |
| GWAS Catalog | 170 unique SNPs / 392 rows |
| ClinVar | 58 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 114 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘ST3GAL6’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 58 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 291 traits by best p-value, aggregated from 424 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9Y274 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000064225/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/ST3GAL6 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/ST3GAL6 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=ST3GAL6%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/ST3GAL6 — GWAS Catalog search API (live; release not exposed)