Protein Dossier — STK17B (Serine/threonine-protein kinase 17B)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Myocardial infarction |
-0.155 |
0.0444 |
4.76e-04 |
Wald ratio |
1 |
trans |
NA |
| Coronary heart disease |
-0.134 |
0.0403 |
8.64e-04 |
Wald ratio |
1 |
trans |
NA |
| Amyotrophic lateral sclerosis |
-0.237 |
0.0729 |
0.00113 |
Wald ratio |
1 |
trans |
NA |
| Eczema |
0.214 |
0.0713 |
0.00266 |
Wald ratio |
1 |
trans |
NA |
| Years of schooling |
-0.0476 |
0.0159 |
0.0027 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: N92 Excessive frequent and irregular menstruation |
0.168 |
0.0565 |
0.00295 |
Wald ratio |
1 |
trans |
NA |
| Chronic kidney disease |
0.174 |
0.0634 |
0.00596 |
Wald ratio |
1 |
trans |
NA |
| Forced vital capacity (FVC) |
-0.0214 |
0.00785 |
0.00649 |
Wald ratio |
1 |
trans |
NA |
| LDL cholesterol |
-0.0598 |
0.0222 |
0.00701 |
Wald ratio |
1 |
trans |
NA |
| Sodium in urine |
0.0238 |
0.00941 |
0.0115 |
Wald ratio |
1 |
trans |
NA |
| Heel bone mineral density (BMD) T-score automated |
0.0303 |
0.0124 |
0.0143 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) |
-0.203 |
0.0837 |
0.0155 |
Wald ratio |
1 |
trans |
NA |
| …and 99 more outcomes (see JSON) |
|
|
|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5249_31_3 |
DRAK2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
36 association rows across 24 traits (31 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Vertex-wise sulcal depth |
9e-33 |
rs1054537 |
1 |
GCST90095129 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
2e-32 |
rs4514889 |
2 |
GCST90838669 |
no MR -> candidate analysis |
| Mean reticulocyte volume (UKB data field 30260) |
2e-16 |
rs539299744 |
1 |
GCST90468088 |
no MR -> candidate analysis |
| Mean sphered cell volume (UKB data field 30270) |
5e-16 |
rs75229287 |
1 |
GCST90468089 |
no MR -> candidate analysis |
| Vertex-wise cortical thickness |
1e-15 |
rs1519602 |
1 |
GCST90095131 |
no MR -> candidate analysis |
| Cortical thickness |
4e-15 |
rs1519602 |
1 |
GCST90091061 |
no MR -> candidate analysis |
| Mean corpuscular volume |
6e-15 |
rs76005009 |
4 |
GCST90002338 |
no MR -> candidate analysis |
| Mean spheric corpuscular volume |
3e-14 |
rs539299744 |
1 |
GCST90002397 |
no MR -> candidate analysis |
| Mean corpuscular hemoglobin |
3e-13 |
rs17302154 |
3 |
GCST007068 |
no MR -> candidate analysis |
| Eosinophill percentage (UKB data field 30210) |
5e-13 |
rs539299744 |
1 |
GCST90468069 |
no MR -> candidate analysis |
| Eosinophil percentage of white cells |
3e-12 |
rs539299744 |
1 |
GCST90002382 |
no MR -> candidate analysis |
| Brain morphology (MOSTest) |
3e-12 |
rs1519602 |
1 |
GCST90239729 |
no MR -> candidate analysis |
| …and 12 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 123 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| frozen shoulder |
0.5 |
— |
common-variant locus |
no MR -> candidate analysis |
| placental retention |
0.484 |
— |
common-variant locus |
no MR -> candidate analysis |
| type 2 diabetes mellitus |
0.3 |
— |
common-variant locus |
no MR -> candidate analysis |
| smoking initiation |
0.297 |
— |
common-variant locus |
no MR -> candidate analysis |
| depressive disorder |
0.215 |
— |
common-variant locus |
no MR -> candidate analysis |
| anxiety disorder |
0.212 |
— |
common-variant locus |
no MR -> candidate analysis |
| hypothyroidism |
0.203 |
— |
common-variant locus |
MR: beta=-0.0405, p=0.361 (trans) |
| mood disorder |
0.176 |
— |
common-variant locus |
no MR -> candidate analysis |
| ulcerative colitis |
0.176 |
— |
common-variant locus |
no MR -> candidate analysis |
| generalized dystonia |
0.173 |
— |
common-variant locus |
no MR -> candidate analysis |
| hypertrophic cardiomyopathy |
0.103 |
— |
common-variant locus |
no MR -> candidate analysis |
| mental disorder |
0.055 |
— |
common-variant locus |
no MR -> candidate analysis |
| upper extremity fracture |
0.041 |
— |
common-variant locus |
no MR -> candidate analysis |
| ovarian dysfunction |
0.041 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 14 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Serine/threonine-protein kinase 17B) |
| gnomAD constraint |
pLI=0.0042, LOEUF=0.72 — LoF-tolerant |
| GWAS Catalog |
36 unique SNPs / 71 rows |
| ClinVar |
75 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 123 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘STK17B’ and resolved to ‘Serine/threonine-protein kinase 17B’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 75 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 24 traits by best p-value, aggregated from 36 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/O94768 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000081320/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3980/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/STK17B — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/STK17B — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=STK17B%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/STK17B — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:15:29 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none