MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: gout | 0.569 | 0.0578 | 7.21e-23 | Wald ratio | 1 | trans | 0.981 |
| Urate | 0.278 | 0.0286 | 3.11e-22 | Wald ratio | 1 | trans | NA |
| Triglycerides | 0.119 | 0.0169 | 1.77e-12 | Wald ratio | 1 | trans | 0.991 |
| HDL cholesterol | -0.118 | 0.0178 | 3.26e-11 | Wald ratio | 1 | trans | 0.992 |
| Serum creatinine (eGFRcrea) | -0.0239 | 0.00434 | 3.80e-08 | Wald ratio | 1 | trans | 0.992 |
| Creatinine (enzymatic) in urine | -0.0572 | 0.0116 | 8.59e-07 | Wald ratio | 1 | trans | NA |
| Potassium in urine | -0.0554 | 0.0123 | 6.78e-06 | Wald ratio | 1 | trans | NA |
| Ferritin | 0.176 | 0.0482 | 2.64e-04 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: asthma | -0.139 | 0.0391 | 3.87e-04 | Wald ratio | 1 | trans | NA |
| LDL cholesterol | 0.0664 | 0.0191 | 5.07e-04 | Wald ratio | 1 | trans | NA |
| Haemoglobin concentration | -0.115 | 0.0339 | 7.13e-04 | Wald ratio | 1 | trans | NA |
| Neuroticism | 0.0564 | 0.0174 | 0.00115 | Wald ratio | 1 | trans | NA |
| …and 114 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
177 association rows across 126 traits (156 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Phospholipids in HDL | 2e-47 | rs4239651 | 2 | GCST90501117 | no MR -> candidate analysis |
| Total Lipids in HDL | 6e-46 | rs4239651 | 2 | GCST90501115 | no MR -> candidate analysis |
| High density lipoprotein cholesterol levels | 2e-44 | rs4239651 | 7 | GCST90239649 | no MR -> candidate analysis |
| Concentration of medium HDL particles | 4e-44 | rs4239651 | 3 | GCST90501189 | no MR -> candidate analysis |
| Free cholesterol in medium HDL | 4e-43 | rs4239651 | 2 | GCST90501186 | no MR -> candidate analysis |
| Apolipoprotein A1 levels | 2e-42 | rs4239651 | 8 | GCST90501098 | no MR -> candidate analysis |
| Total lipids in medium HDL | 2e-42 | rs4239651 | 2 | GCST90501188 | no MR -> candidate analysis |
| Cholesterol in Medium HDL | 6e-42 | rs4239651 | 2 | GCST90501182 | no MR -> candidate analysis |
| Phospholipids in medium HDL | 1e-41 | rs4239651 | 2 | GCST90501190 | no MR -> candidate analysis |
| Cholesteryl Esters in Medium HDL | 7e-41 | rs4239651 | 2 | GCST90501184 | no MR -> candidate analysis |
| Free Cholesterol in HDL | 5e-38 | rs4239651 | 1 | GCST90501114 | no MR -> candidate analysis |
| Phospholipids to Total Lipids in Small HDL percentage | 1e-32 | rs4239651 | 2 | GCST90501243 | no MR -> candidate analysis |
| …and 114 more traits (see JSON) |
Top diseases by Open Targets association (of 365 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| osteoarthritis, knee | 0.748 | — | common-variant locus | MR: beta=-0.253, p=0.0641 (trans) |
| alcohol drinking | 0.684 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.569 | — | common-variant locus | no MR -> candidate analysis |
| liver disorder | 0.539 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.482 | — | common-variant locus | no MR -> candidate analysis |
| osteoarthritis | 0.461 | — | common-variant locus | MR: beta=-0.253, p=0.0641 (trans) |
| osteoarthritis, hip | 0.461 | — | common-variant locus | MR: beta=-0.128, p=0.276 (trans) |
| total knee arthroplasty | 0.461 | — | common-variant locus | no MR -> candidate analysis |
| squamous cell carcinoma | 0.43 | — | common-variant locus | no MR -> candidate analysis |
| arthropathy | 0.43 | — | common-variant locus | no MR -> candidate analysis |
| head injury | 0.406 | — | common-variant locus | no MR -> candidate analysis |
| Sjogren syndrome | 0.364 | — | common-variant locus | no MR -> candidate analysis |
| non-Hodgkin lymphoma | 0.363 | — | common-variant locus | no MR -> candidate analysis |
| lymphatic system cancer | 0.363 | — | common-variant locus | no MR -> candidate analysis |
| musculoskeletal system disorder | 0.345 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=2.2e-05, LOEUF=0.608 — LoF-tolerant |
| GWAS Catalog | 61 unique SNPs / 121 rows |
| ClinVar | 188 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 365 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘SULF2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 188 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 126 traits by best p-value, aggregated from 177 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q8IWU5 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000196562/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/SULF2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/SULF2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=SULF2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/SULF2 — GWAS Catalog search API (live; release not exposed)