MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: gout | 0.0524 | 0.017 | 0.00206 | Wald ratio | 1 | cis | NA |
| Nucleus accumbens volume | -2.47 | 0.942 | 0.00864 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R14 Flatulence and related conditions | 0.189 | 0.074 | 0.0109 | Wald ratio | 1 | cis | NA |
| Bulimia nervosa | 0.0151 | 0.00605 | 0.0124 | Wald ratio | 1 | cis | NA |
| Heel bone mineral density (BMD) T-score automated | -0.00693 | 0.00277 | 0.0125 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: J33 Nasal polyp | -0.0819 | 0.0337 | 0.0151 | Wald ratio | 1 | cis | NA |
| Microalbuminuria | 0.0409 | 0.0174 | 0.0189 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: C61 Malignant neoplasm of prostate | -0.0657 | 0.028 | 0.019 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: prostate cancer | -0.0594 | 0.0266 | 0.0253 | Wald ratio | 1 | cis | NA |
| Neuroticism | 0.00605 | 0.00303 | 0.0455 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux | 0.0197 | 0.0101 | 0.0505 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoarthritis | -0.0139 | 0.00725 | 0.0558 | Wald ratio | 1 | cis | NA |
| …and 93 more outcomes (see JSON) |
| Dataset | Trait | Author | Year |
|---|---|---|---|
prot-c-2672_60_1 |
Cripto | Suhre K | 2019 |
No GWAS Catalog associations mapped to this gene.
Top diseases by Open Targets association (of 280 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| midline interhemispheric variant of holoprosencephaly | 0.608 | — | established (curated) | no MR -> candidate analysis |
| lobar holoprosencephaly | 0.608 | — | established (curated) | no MR -> candidate analysis |
| microform holoprosencephaly | 0.608 | — | established (curated) | no MR -> candidate analysis |
| alobar holoprosencephaly | 0.608 | — | established (curated) | no MR -> candidate analysis |
| septopreoptic holoprosencephaly | 0.608 | — | established (curated) | no MR -> candidate analysis |
| semilobar holoprosencephaly | 0.608 | — | established (curated) | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.216 | — | common-variant locus | no MR -> candidate analysis |
Of the 7 rows above, 7 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 1 known modulators (Protein Cripto) |
| gnomAD constraint | not available |
| GWAS Catalog | no mapped SNPs |
| ClinVar | no records |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 280 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘TDGF1’ and resolved to ‘Protein Cripto’ — confirm this is the intended target.gnomad — No gnomAD constraint data.gwas — No GWAS Catalog SNPs mapped to this gene.clinvar — No ClinVar records.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — No GWAS Catalog associations mapped to this gene.uniprot: https://www.uniprot.org/uniprotkb/P13385 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000241186/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3713025/ — ChEMBL_37 (released 2026-05-01)