MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: R55 Syncope and collapse | 0.312 | 0.0967 | 0.00124 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: anxiety or panic attacks | 0.25 | 0.0834 | 0.00277 | Wald ratio | 1 | trans | NA |
| Hearing difficulty or problems: Yes | -0.0663 | 0.0228 | 0.00359 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: osteoarthritis | -0.111 | 0.0462 | 0.0162 | Wald ratio | 1 | trans | NA |
| Cancer code self-reported: basal cell carcinoma | -0.416 | 0.205 | 0.0428 | Wald ratio | 1 | trans | NA |
| Caudate volume | -64.6 | 32.6 | 0.0477 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: asthma | -0.0696 | 0.0371 | 0.0605 | Wald ratio | 1 | trans | NA |
| Pulse rate | -0.041 | 0.0219 | 0.0615 | Wald ratio | 1 | trans | NA |
| Amygdala volume | 30.3 | 16.3 | 0.0622 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: hypertension | -0.0407 | 0.0219 | 0.0633 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis | 0.235 | 0.146 | 0.108 | Wald ratio | 1 | trans | NA |
| Lung adenocarcinoma | -0.254 | 0.163 | 0.119 | Wald ratio | 1 | trans | NA |
| …and 47 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
96 association rows across 57 traits (79 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Bone mineral density mean | 1e-300 | rs534919147 | 3 | GCST90321120 | no MR -> candidate analysis |
| Body mass index | 7e-21 | rs2479958 | 18 | GCST90255621 | no MR -> candidate analysis |
| Height | 4e-20 | rs11619721 | 3 | GCST90245848 | no MR -> candidate analysis |
| Menarche (age at onset) | 2e-17 | rs9560113 | 5 | GCST002541 | no MR -> candidate analysis |
| Leg fat percentage left (UKB data field 23115) | 2e-17 | rs1183668 | 1 | GCST90468174 | no MR -> candidate analysis |
| Body mass index (UKB data field 21001) | 7e-17 | rs2528787 | 1 | GCST90468161 | no MR -> candidate analysis |
| Leg fat percentage right (UKB data field 23111) | 3e-16 | rs2528787 | 1 | GCST90468175 | no MR -> candidate analysis |
| Weight | 6e-16 | rs9522183 | 2 | GCST90662910 | no MR -> candidate analysis |
| Body mass index (MTAG) | 1e-15 | rs9522279 | 2 | GCST90179150 | no MR -> candidate analysis |
| Body fat percentage (UKB data field 23099) | 8e-14 | rs1183668 | 1 | GCST90468160 | no MR -> candidate analysis |
| Metabolic syndrome | 1e-13 | rs9522264 | 2 | GCST90444487 | no MR -> candidate analysis |
| Waist circumference (UKB data field 48) | 1e-12 | rs1183668 | 1 | GCST90468182 | no MR -> candidate analysis |
| …and 45 more traits (see JSON) |
Top diseases by Open Targets association (of 38 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| insomnia | 0.669 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.522 | — | common-variant locus | no MR -> candidate analysis |
| dyshidrosis | 0.517 | — | common-variant locus | no MR -> candidate analysis |
| amino acid metabolism disease | 0.517 | — | common-variant locus | no MR -> candidate analysis |
| Hepatitis | 0.442 | — | common-variant locus | no MR -> candidate analysis |
| ocular hypotension | 0.423 | — | common-variant locus | no MR -> candidate analysis |
| benign urinary system neoplasm | 0.412 | — | common-variant locus | no MR -> candidate analysis |
| benign chondrogenic neoplasm | 0.409 | — | common-variant locus | no MR -> candidate analysis |
| response to xenobiotic stimulus | 0.409 | — | common-variant locus | no MR -> candidate analysis |
| diabetic ketoacidosis | 0.331 | — | common-variant locus | no MR -> candidate analysis |
| gout | 0.228 | — | common-variant locus | no MR -> candidate analysis |
| digestive system disorder | 0.219 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.207 | — | common-variant locus | no MR -> candidate analysis |
| systemic lupus erythematosus | 0.111 | — | common-variant locus | no MR -> candidate analysis |
| female reproductive system disorder | 0.103 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=5.5e-12, LOEUF=1.98 — LoF-tolerant |
| GWAS Catalog | 80 unique SNPs / 116 rows |
| ClinVar | 155 records; 6 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 38 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘TEX29’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 155 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 57 traits by best p-value, aggregated from 96 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q8N6K0 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000153495/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/TEX29 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TEX29 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TEX29%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TEX29 — GWAS Catalog search API (live; release not exposed)