MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Height |
-0.0431 |
0.011 |
9.11e-05 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M72 Fibroblastic disorders |
0.306 |
0.0906 |
7.36e-04 |
Wald ratio |
1 |
cis |
NA |
| Pulse rate |
0.0434 |
0.0158 |
0.00598 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R14 Flatulence and related conditions |
0.59 |
0.219 |
0.00692 |
Wald ratio |
1 |
cis |
NA |
| Intracranial volume |
1.89e+04 |
7e+03 |
0.00697 |
Wald ratio |
1 |
cis |
NA |
| Type 2 diabetes |
-0.0938 |
0.0352 |
0.00772 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
-0.0195 |
0.00735 |
0.00786 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: anxiety or panic attacks |
0.168 |
0.0655 |
0.0103 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
-0.0155 |
0.00699 |
0.027 |
Wald ratio |
1 |
cis |
NA |
| Fasting insulin |
0.0263 |
0.012 |
0.0278 |
Wald ratio |
1 |
cis |
NA |
| Sodium in urine |
0.0189 |
0.00882 |
0.0319 |
Wald ratio |
1 |
cis |
NA |
| Parkinson’s disease |
-0.322 |
0.151 |
0.0326 |
Wald ratio |
1 |
cis |
NA |
| …and 111 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2278_61_4 |
TIMP-2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
50 association rows across 35 traits (40 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| LGALS3BP protein levels |
1e-77 |
rs111526614 |
1 |
GCST90469760 |
no MR -> candidate analysis |
| Height |
2e-66 |
rs8066695 |
6 |
GCST90245848 |
MR: beta=-0.0431, p=9.11e-05 (cis) |
| Serum levels of protein TIMP2 |
4e-47 |
rs2376999 |
2 |
GCST90087930 |
no MR -> candidate analysis |
| TIMP2 protein levels |
5e-44 |
rs8066695 |
2 |
GCST90470870 |
no MR -> candidate analysis |
| Galectin-3-binding protein levels |
4e-35 |
rs111526614 |
2 |
GCST90247672 |
no MR -> candidate analysis |
| Circulating DSG4 levels |
3e-30 |
rs55842605 |
1 |
GCST90860253 |
no MR -> candidate analysis |
| Blood protein levels |
3e-29 |
rs2376999 |
1 |
GCST006585 |
no MR -> candidate analysis |
| DSG4 protein levels |
3e-29 |
rs55842605 |
1 |
GCST90469044 |
no MR -> candidate analysis |
| DSG3/DSG4 protein level ratio |
2e-27 |
rs7220336 |
1 |
GCST90314558 |
no MR -> candidate analysis |
| Heel bone mineral density |
9e-16 |
rs35881190 |
4 |
GCST006433 |
no MR -> candidate analysis |
| Estimated bone mineral density |
1e-15 |
rs35881190 |
1 |
GCST90726625 |
no MR -> candidate analysis |
| Height (baseline) |
2e-14 |
rs55646445 |
2 |
GCST90565843 |
no MR -> candidate analysis |
| …and 23 more traits (see JSON) |
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|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 947 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| coronary artery disorder |
0.545 |
— |
common-variant locus |
no MR -> candidate analysis |
| Abnormality of the skeletal system |
0.511 |
— |
common-variant locus |
no MR -> candidate analysis |
| benign neoplasm |
0.432 |
— |
common-variant locus |
MR: beta=-0.136, p=0.119 (cis) |
| neuroendocrine neoplasm |
0.212 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 4 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1, LOEUF=0.433 — LoF-INTOLERANT |
| GWAS Catalog |
92 unique SNPs / 184 rows |
| ClinVar |
62 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 947 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘TIMP2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 62 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 35 traits by best p-value, aggregated from 50 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P16035 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000035862/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/TIMP2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TIMP2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TIMP2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TIMP2 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:21:36 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none