MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Serum cystatin C (eGFRcys) | -0.108 | 0.00362 | 9.81e-198 | Wald ratio | 1 | trans | 0.904 |
| Eye problems or disorders: Diabetes related eye disease | 0.196 | 0.0495 | 7.76e-05 | Wald ratio | 1 | trans | NA |
| Autism | -0.187 | 0.057 | 0.00102 | Wald ratio | 1 | trans | NA |
| Alcohol intake frequency | -0.0188 | 0.00695 | 0.00685 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: osteoporosis | -0.109 | 0.0422 | 0.00944 | Wald ratio | 1 | trans | NA |
| PGC cross-disorder traits | -0.0582 | 0.024 | 0.0153 | Wald ratio | 1 | trans | NA |
| Height | 0.0136 | 0.00575 | 0.0177 | Wald ratio | 1 | trans | NA |
| Heel bone mineral density (BMD) T-score automated | 0.0141 | 0.00609 | 0.0208 | Wald ratio | 1 | trans | NA |
| Birth weight | 0.0159 | 0.00707 | 0.0241 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) | 0.0685 | 0.0311 | 0.0279 | Wald ratio | 1 | trans | NA |
| Eye problems or disorders: Injury or trauma resulting in loss of vision | -0.158 | 0.0722 | 0.0283 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: asthma | 0.0277 | 0.0128 | 0.0309 | Wald ratio | 1 | trans | NA |
| …and 109 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
16 association rows across 14 traits (13 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Height | 3e-75 | rs876402 | 3 | GCST90245848 | MR: beta=0.0136, p=0.0177 (trans) |
| TMPRSS5 protein levels | 2e-21 | rs546034924 | 1 | GCST90470893 | no MR -> candidate analysis |
| Circulating TMPRSS5 levels | 8e-20 | rs10149880 | 1 | GCST90859695 | no MR -> candidate analysis |
| PGF protein levels | 7e-18 | rs190193666 | 1 | GCST90470218 | no MR -> candidate analysis |
| IGF 1 (UKB data field 30770) | 1e-17 | rs12433944 | 1 | GCST90468078 | no MR -> candidate analysis |
| Diseases of sebaceous glands (PheCode 706) | 3e-15 | rs4903293 | 1 | GCST90480484 | no MR -> candidate analysis |
| Heel bone mineral density | 4e-15 | rs876403 | 1 | GCST006433 | MR: beta=0.0141, p=0.0208 (trans) |
| Alzheimer’s disease (PheCode 290.11) | 3e-11 | rs568436451 | 1 | GCST90480731 | no MR -> candidate analysis |
| Body size or adipose distribution (multivariate analysis) | 5e-10 | rs175426 | 1 | GCST90624105 | no MR -> candidate analysis |
| Hypothyroidism | 7e-9 | rs7156476 | 1 | GCST90627750 | no MR -> candidate analysis |
| Gut microbial network clusters (Salmon (at 1 year) x Any Bre | 1e-8 | rs56201181 | 1 | GCST90569461 | no MR -> candidate analysis |
| Coronary artery disease | 4e-8 | rs2098297 | 1 | GCST010479 | MR: beta=0.0192, p=0.286 (trans) |
| …and 2 more traits (see JSON) |
Top diseases by Open Targets association (of 130 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Alzheimer disease | 0.267 | — | common-variant locus | no MR -> candidate analysis |
| Pilonidal abscess | 0.265 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.241 | — | common-variant locus | no MR -> candidate analysis |
| hypothyroidism | 0.218 | — | common-variant locus | no MR -> candidate analysis |
| Epidermal Inclusion Cyst | 0.202 | — | common-variant locus | no MR -> candidate analysis |
| sebaceous gland disorder | 0.158 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.067 | — | common-variant locus | no MR -> candidate analysis |
| skin infection | 0.065 | — | common-variant locus | no MR -> candidate analysis |
| subcutaneous tissue infection | 0.065 | — | common-variant locus | no MR -> candidate analysis |
| abdominal aortic aneurysm | 0.058 | — | common-variant locus | no MR -> candidate analysis |
Of the 10 rows above, 10 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Transmembrane emp24 domain-containing protein 10) |
| gnomAD constraint | pLI=0.91, LOEUF=0.57 — LoF-INTOLERANT |
| GWAS Catalog | 45 unique SNPs / 90 rows |
| ClinVar | 50 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 130 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘TMED10’ and resolved to ‘Transmembrane emp24 domain-containing protein 10’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 50 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 14 of 14 traits by best p-value, aggregated from 16 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P49755 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000170348/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4295772/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/TMED10 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TMED10 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TMED10%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TMED10 — GWAS Catalog search API (live; release not exposed)