MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: depression | 0.172 | 0.031 | 2.81e-08 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.0355 | 0.00894 | 6.98e-05 | Wald ratio | 1 | cis | NA |
| Sleep duration | -0.027 | 0.00698 | 1.08e-04 | Wald ratio | 1 | cis | NA |
| Height | 0.0404 | 0.011 | 2.46e-04 | Wald ratio | 1 | cis | NA |
| Autism | 0.312 | 0.106 | 0.00324 | Wald ratio | 1 | cis | NA |
| Vascular or heart problems diagnosed by doctor: Angina | 0.129 | 0.0441 | 0.0035 | Wald ratio | 1 | cis | NA |
| Melanoma | 0.592 | 0.208 | 0.00439 | Wald ratio | 1 | cis | NA |
| Coronary heart disease | -0.1 | 0.0354 | 0.00474 | Wald ratio | 1 | cis | NA |
| Childhood intelligence | -0.132 | 0.0478 | 0.00589 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: high cholesterol | 0.06 | 0.0228 | 0.00841 | Wald ratio | 1 | cis | NA |
| Myocardial infarction | -0.102 | 0.0393 | 0.00913 | Wald ratio | 1 | cis | NA |
| Depressive symptoms | -0.0368 | 0.0147 | 0.0124 | Wald ratio | 1 | cis | NA |
| …and 119 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
195 association rows across 134 traits (148 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Height | 1e-79 | rs6460895 | 5 | GCST90245848 | MR: beta=0.0404, p=2.46e-04 (cis) |
| Transmembrane protein 106B levels | 6e-59 | rs5011434 | 2 | GCST90249753 | no MR -> candidate analysis |
| Serum levels of protein TMEM106B | 1e-42 | rs1548884 | 1 | GCST90090262 | no MR -> candidate analysis |
| DPP4 protein levels | 4e-31 | rs10644564 | 1 | GCST90469033 | no MR -> candidate analysis |
| GFAP protein levels | 1e-28 | rs6460901 | 1 | GCST90469325 | no MR -> candidate analysis |
| Blood protein levels | 6e-27 | rs10950398 | 1 | GCST006585 | no MR -> candidate analysis |
| Circulating DPP4 levels | 7e-27 | rs4721061 | 1 | GCST90860464 | no MR -> candidate analysis |
| Educational attainment | 8e-26 | rs7810903 | 3 | GCST90105038 | no MR -> candidate analysis |
| Depression | 8e-24 | rs2043539 | 7 | GCST007342 | MR: beta=0.172, p=2.81e-08 (cis) |
| Differential aging in older adults (frontal cortex) | 3e-23 | rs1990622 | 1 | GCST008795 | no MR -> candidate analysis |
| Core binding factor acute myeloid leukemia | 7e-20 | rs10237821; rs12537849; rs7794113; rs10269431 | 2 | GCST008413 | no MR -> candidate analysis |
| GLIPR1 protein levels | 1e-19 | rs76752104 | 2 | GCST90469357 | no MR -> candidate analysis |
| …and 122 more traits (see JSON) |
Top diseases by Open Targets association (of 885 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| leukodystrophy, hypomyelinating, 16 | 0.774 | — | established (curated) | no MR -> candidate analysis |
| major depressive disorder | 0.852 | — | common-variant locus | MR: beta=-0.123, p=0.12 (cis) |
| type 2 diabetes mellitus | 0.81 | — | common-variant locus | no MR -> candidate analysis |
| coronary artery disorder | 0.737 | — | common-variant locus | no MR -> candidate analysis |
| Alzheimer disease | 0.701 | — | common-variant locus | no MR -> candidate analysis |
| diabetes mellitus | 0.725 | — | common-variant locus | no MR -> candidate analysis |
| frontotemporal dementia | 0.659 | — | common-variant locus | no MR -> candidate analysis |
| dementia | 0.659 | — | common-variant locus | no MR -> candidate analysis |
| mental disorder | 0.684 | — | common-variant locus | no MR -> candidate analysis |
| insomnia | 0.656 | — | common-variant locus | no MR -> candidate analysis |
| aging | 0.638 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.636 | — | common-variant locus | no MR -> candidate analysis |
| sleep disorder | 0.634 | — | common-variant locus | MR: beta=0.217, p=0.022 (cis) |
| neurodegenerative disease | 0.539 | — | common-variant locus | no MR -> candidate analysis |
| depressive disorder | 0.539 | — | common-variant locus | MR: beta=-0.123, p=0.12 (cis) |
Of the 15 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.028, LOEUF=0.743 — LoF-tolerant |
| GWAS Catalog | 112 unique SNPs / 244 rows |
| ClinVar | 183 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 885 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘TMEM106B’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 183 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 134 traits by best p-value, aggregated from 195 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9NUM4 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000106460/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/TMEM106B — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TMEM106B — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TMEM106B%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TMEM106B — GWAS Catalog search API (live; release not exposed)