MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Potassium in urine | 0.0504 | 0.0141 | 3.65e-04 | Wald ratio | 1 | trans | NA |
| Sodium in urine | 0.0381 | 0.0137 | 0.00548 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis | 0.271 | 0.102 | 0.00773 | Wald ratio | 1 | trans | NA |
| Fractured bone site(s): Wrist | 0.208 | 0.0813 | 0.0105 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: mania or bipolar disorder or manic depression | 0.447 | 0.182 | 0.014 | Wald ratio | 1 | trans | NA |
| Cancer code self-reported: malignant melanoma | 0.277 | 0.122 | 0.0229 | Wald ratio | 1 | trans | NA |
| Squamous cell lung cancer | 0.335 | 0.148 | 0.0235 | Wald ratio | 1 | trans | NA |
| Autism | -0.371 | 0.171 | 0.0302 | Wald ratio | 1 | trans | NA |
| Happiness | -0.0369 | 0.0172 | 0.0316 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain | -0.166 | 0.08 | 0.0381 | Wald ratio | 1 | trans | NA |
| Creatinine (enzymatic) in urine | 0.0271 | 0.0133 | 0.042 | Wald ratio | 1 | trans | NA |
| Urate | -0.062 | 0.0317 | 0.0507 | Wald ratio | 1 | trans | NA |
| …and 72 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
68 association rows across 52 traits (26 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Transmembrane protein 132B levels | 2e-23 | rs148179158 | 2 | GCST90249903 | no MR -> candidate analysis |
| Type 2 diabetes | 6e-23 | rs11058150 | 1 | GCST90134620 | MR: beta=0.0722, p=0.323 (trans) |
| Smoking initiation | 5e-21 | rs1666839 | 3 | GCST90243985 | no MR -> candidate analysis |
| Serum levels of protein ASH2L | 8e-13 | rs146549691 | 1 | GCST90087257 | no MR -> candidate analysis |
| Bone mineral density mean | 4e-11 | rs188062158 | 1 | GCST90321120 | no MR -> candidate analysis |
| Protein quantitative trait loci (liver) | 5e-11 | rs74824119 | 1 | GCST011427 | no MR -> candidate analysis |
| Gut microbial network clusters (Turquoise (at 3 months) x An | 6e-11 | rs12578940 | 1 | GCST90569243 | no MR -> candidate analysis |
| Non-alcoholic fatty liver disease or type 2 diabetes | 7e-11 | rs73233361 | 1 | GCST90272881 | no MR -> candidate analysis |
| Triglyceride levels x short total sleep time interaction (2d | 9e-11 | rs10744213 | 1 | GCST009363 | no MR -> candidate analysis |
| Smoking initiation (ever regular vs never regular) (MTAG) | 4e-10 | rs1666839 | 1 | GCST007468 | no MR -> candidate analysis |
| Risk-taking behavior (multivariate analysis) | 1e-9 | rs326391 | 1 | GCST90239693 | no MR -> candidate analysis |
| Lifetime major depressive disorder (AutoComplete Impute and | 3e-9 | rs434211 | 1 | GCST90449002 | no MR -> candidate analysis |
| …and 40 more traits (see JSON) |
Top diseases by Open Targets association (of 123 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| smoking initiation | 0.601 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.571 | — | common-variant locus | no MR -> candidate analysis |
| major depressive disorder | 0.512 | — | common-variant locus | no MR -> candidate analysis |
| stomach disorder | 0.512 | — | common-variant locus | no MR -> candidate analysis |
| risk-taking behaviour | 0.509 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.504 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.489 | — | common-variant locus | no MR -> candidate analysis |
| preeclampsia | 0.479 | — | common-variant locus | no MR -> candidate analysis |
| deficiency anemia | 0.479 | — | common-variant locus | no MR -> candidate analysis |
| metabolic dysfunction-associated steatotic liver disease | 0.477 | — | common-variant locus | no MR -> candidate analysis |
| peripheral vascular disease | 0.472 | — | common-variant locus | no MR -> candidate analysis |
| Thromboembolism | 0.472 | — | common-variant locus | no MR -> candidate analysis |
| corneal degeneration | 0.47 | — | common-variant locus | no MR -> candidate analysis |
| nephrotic syndrome | 0.41 | — | common-variant locus | no MR -> candidate analysis |
| ovarian neoplasm | 0.41 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1, LOEUF=0.294 — LoF-INTOLERANT |
| GWAS Catalog | 71 unique SNPs / 129 rows |
| ClinVar | 165 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 123 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘TMEM132B’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 165 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 52 traits by best p-value, aggregated from 68 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q14DG7 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000139364/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/TMEM132B — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TMEM132B — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TMEM132B%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TMEM132B — GWAS Catalog search API (live; release not exposed)