MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Ischemic stroke | 0.171 | 0.0587 | 0.00358 | Inverse variance weighted | 2 | cis | NA |
| Ischemic stroke | 0.171 | 0.0587 | 0.00358 | Inverse variance weighted | 2 | trans | NA |
| Thyroid cancer | -0.887 | 0.306 | 0.00378 | Inverse variance weighted | 2 | cis | NA |
| Thyroid cancer | -0.887 | 0.306 | 0.00378 | Inverse variance weighted | 2 | trans | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | 0.137 | 0.0522 | 0.00847 | Inverse variance weighted | 2 | cis | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | 0.137 | 0.0522 | 0.00847 | Inverse variance weighted | 2 | trans | NA |
| Diagnoses - main ICD10: L03 Cellulitis | 0.204 | 0.0781 | 0.00917 | Inverse variance weighted | 2 | cis | NA |
| Diagnoses - main ICD10: L03 Cellulitis | 0.204 | 0.0781 | 0.00917 | Inverse variance weighted | 2 | trans | NA |
| Ferritin | 0.115 | 0.0497 | 0.0208 | Wald ratio | 1 | trans | NA |
| Fasting glucose | 0.0884 | 0.0405 | 0.0291 | Wald ratio | 1 | trans | NA |
| Depressive symptoms | -0.0479 | 0.0221 | 0.0303 | Wald ratio | 1 | trans | NA |
| Autism | -0.208 | 0.0996 | 0.0369 | Inverse variance weighted | 2 | cis | NA |
| …and 173 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
67 association rows across 54 traits (28 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Serum levels of protein TMEM132C | 4e-41 | rs7979166 | 2 | GCST90089706 | no MR -> candidate analysis |
| Transmembrane protein 132C levels | 9e-40 | rs11608284 | 3 | GCST90249904 | no MR -> candidate analysis |
| Blood protein levels | 3e-27 | rs28654182 | 1 | GCST006585 | no MR -> candidate analysis |
| Transmembrane protein 132C levels (TMEM132C.7173.141.3) | 2e-18 | rs11059617 | 2 | GCST90243090 | no MR -> candidate analysis |
| Random glucose levels | 1e-12 | rs78405915 | 1 | GCST90134505 | no MR -> candidate analysis |
| Fracture of hand or wrist (PheCode 804) | 9e-12 | rs542492963 | 1 | GCST90480603 | no MR -> candidate analysis |
| Core binding factor acute myeloid leukemia | 1e-11 | rs6486446; rs11059599 | 4 | GCST008413 | no MR -> candidate analysis |
| Cholelithiasis with acute cholecystitis (PheCode 574.11) | 3e-11 | rs141689732 | 1 | GCST90480349 | no MR -> candidate analysis |
| Uterine fibroids | 4e-10 | rs10773567 | 1 | GCST90461957 | MR: beta=0.0755, p=0.24 (cis) |
| Adolescent idiopathic scoliosis | 7e-10 | rs1713616 | 3 | GCST006287 | no MR -> candidate analysis |
| Alzheimer’s disease or family history of Alzheimer’s disease | 1e-9 | rs1875936746 | 2 | GCST90624094 | no MR -> candidate analysis |
| Neurofibrillary tangles (SNP x SNP interaction) | 3e-9 | rs10773782 x rs6486496 | 2 | GCST010343 | no MR -> candidate analysis |
| …and 42 more traits (see JSON) |
Top diseases by Open Targets association (of 98 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| alcohol drinking | 0.722 | — | common-variant locus | no MR -> candidate analysis |
| adolescent idiopathic scoliosis | 0.504 | — | common-variant locus | no MR -> candidate analysis |
| Hydrocephalus | 0.492 | — | common-variant locus | no MR -> candidate analysis |
| bone remodeling disease | 0.485 | — | common-variant locus | no MR -> candidate analysis |
| immune system disorder | 0.484 | — | common-variant locus | no MR -> candidate analysis |
| Meniere disease | 0.479 | — | common-variant locus | no MR -> candidate analysis |
| injury | 0.473 | — | common-variant locus | MR: beta=0.463, p=0.195 (cis) |
| cervical carcinoma | 0.443 | — | common-variant locus | no MR -> candidate analysis |
| squamous cell carcinoma | 0.426 | — | common-variant locus | no MR -> candidate analysis |
| pernicious anemia | 0.426 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.426 | — | common-variant locus | no MR -> candidate analysis |
| osteoarthritis, hip | 0.408 | — | common-variant locus | no MR -> candidate analysis |
| disease of peritoneum | 0.407 | — | common-variant locus | no MR -> candidate analysis |
| jaw disease | 0.407 | — | common-variant locus | no MR -> candidate analysis |
| uterine corpus leiomyoma | 0.407 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.0037, LOEUF=0.644 — LoF-tolerant |
| GWAS Catalog | 89 unique SNPs / 166 rows |
| ClinVar | 263 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 98 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘TMEM132C’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 263 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 54 traits by best p-value, aggregated from 67 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q8N3T6 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000181234/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/TMEM132C — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TMEM132C — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TMEM132C%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TMEM132C — GWAS Catalog search API (live; release not exposed)