MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: C50 Malignant neoplasm of breast | 0.237 | 0.0697 | 6.63e-04 | Wald ratio | 1 | cis | NA |
| Hippocampus volume | -66 | 22.5 | 0.00329 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | -0.0479 | 0.0166 | 0.00394 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: high cholesterol | 0.0772 | 0.0282 | 0.00613 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine | 0.176 | 0.0666 | 0.0081 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: D12 Benign neoplasm of colon rectum anus and anal canal | -0.295 | 0.13 | 0.0235 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: small intestine or small bowel cancer | 0.667 | 0.303 | 0.0276 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: muscle or soft tissue injuries | 0.207 | 0.109 | 0.0581 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R55 Syncope and collapse | 0.189 | 0.0998 | 0.0585 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level | 0.377 | 0.203 | 0.0626 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Glaucoma | -0.2 | 0.117 | 0.0877 | Wald ratio | 1 | cis | NA |
| Pallidum volume | -15.2 | 9.3 | 0.103 | Wald ratio | 1 | cis | NA |
| …and 56 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
94 association rows across 78 traits (26 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Bone mineral density mean | 1e-300 | rs117043263 | 1 | GCST90321120 | no MR -> candidate analysis |
| Transmembrane protein 132B levels | 7e-60 | rs73159540 | 2 | GCST90249903 | no MR -> candidate analysis |
| Transmembrane protein 132D levels | 2e-52 | rs61943557 | 1 | GCST90249905 | no MR -> candidate analysis |
| Serum levels of protein TMEM132D | 9e-34 | rs61943547 | 1 | GCST90087429 | no MR -> candidate analysis |
| Transmembrane protein 132D levels (TMEM132D.13416.8.3) | 3e-27 | rs139574809 | 1 | GCST90243092 | no MR -> candidate analysis |
| Cerebellar grey matter morphology (MOSTest) | 1e-23 | rs10773610 | 2 | GCST90728589 | no MR -> candidate analysis |
| Blood protein levels | 1e-18 | rs61943549 | 1 | GCST006585 | no MR -> candidate analysis |
| GLIPR1 protein levels | 8e-13 | rs529141134 | 1 | GCST90469357 | no MR -> candidate analysis |
| Serum levels of protein TMEM132B | 2e-12 | rs12369635 | 1 | GCST90090363 | no MR -> candidate analysis |
| Transmembrane protein 132B levels (TMEM132B.8890.9.3) | 3e-12 | rs73159540 | 1 | GCST90243089 | no MR -> candidate analysis |
| Free Cholesterol to Cholesteryl Esters in Small HDL ratio | 4e-12 | rs73151095 | 1 | GCST90827928 | no MR -> candidate analysis |
| Pulmonary embolism | 1e-11 | rs708362 | 1 | GCST90278093 | no MR -> candidate analysis |
| …and 66 more traits (see JSON) |
Top diseases by Open Targets association (of 103 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| cutaneous melanoma | 0.6 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.578 | — | common-variant locus | no MR -> candidate analysis |
| cardiovascular disorder | 0.55 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.543 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.535 | — | common-variant locus | no MR -> candidate analysis |
| upper respiratory tract disorder | 0.517 | — | common-variant locus | no MR -> candidate analysis |
| herpes simplex infectious disease | 0.5 | — | common-variant locus | no MR -> candidate analysis |
| pulmonary embolism | 0.497 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.49 | — | common-variant locus | no MR -> candidate analysis |
| bursitis | 0.485 | — | common-variant locus | no MR -> candidate analysis |
| autoimmune disorder of musculoskeletal system | 0.485 | — | common-variant locus | no MR -> candidate analysis |
| optic neuritis | 0.485 | — | common-variant locus | no MR -> candidate analysis |
| neuropathy | 0.485 | — | common-variant locus | no MR -> candidate analysis |
| type 1 diabetes nephropathy | 0.482 | — | common-variant locus | no MR -> candidate analysis |
| polyp | 0.472 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.99, LOEUF=0.485 — LoF-INTOLERANT |
| GWAS Catalog | 108 unique SNPs / 213 rows |
| ClinVar | 252 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 103 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘TMEM132D’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 252 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 78 traits by best p-value, aggregated from 94 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q14C87 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000151952/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/TMEM132D — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TMEM132D — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TMEM132D%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TMEM132D — GWAS Catalog search API (live; release not exposed)