MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Eye problems or disorders: Glaucoma | 0.246 | 0.075 | 0.00104 | Wald ratio | 1 | trans | NA |
| Systolic blood pressure automated reading | 0.0364 | 0.0117 | 0.00188 | Wald ratio | 1 | trans | NA |
| Fractured bone site(s): Wrist | 0.199 | 0.0673 | 0.00312 | Wald ratio | 1 | trans | NA |
| Mean cell haemoglobin concentration | 0.0482 | 0.0172 | 0.00494 | Wald ratio | 1 | trans | NA |
| Cough on most days | 0.142 | 0.0511 | 0.00562 | Wald ratio | 1 | trans | NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | -0.135 | 0.0589 | 0.0219 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: G47 Sleep disorders | 0.263 | 0.117 | 0.0239 | Wald ratio | 1 | trans | NA |
| Small vessel disease | -0.379 | 0.17 | 0.026 | Wald ratio | 1 | trans | NA |
| Percent emphysema | -0.194 | 0.0909 | 0.033 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: M54 Dorsalgia | 0.16 | 0.0762 | 0.0356 | Wald ratio | 1 | trans | NA |
| Forearm bone mineral density | 0.15 | 0.0743 | 0.043 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: D25 Leiomyoma of uterus | 0.17 | 0.086 | 0.0479 | Wald ratio | 1 | trans | NA |
| …and 92 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
No GWAS Catalog associations mapped to this gene.
Top diseases by Open Targets association (of 124 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Inguinal hernia | 0.699 | — | established (curated) | no MR -> candidate analysis |
| Hypertelorism | 0.699 | — | established (curated) | no MR -> candidate analysis |
| myopia | 0.699 | — | established (curated) | no MR -> candidate analysis |
| Retinal dystrophy | 0.699 | — | established (curated) | no MR -> candidate analysis |
| Abnormal sternum morphology | 0.699 | — | established (curated) | no MR -> candidate analysis |
| Joint hypermobility | 0.699 | — | established (curated) | no MR -> candidate analysis |
| smoking initiation | 0.644 | — | common-variant locus | no MR -> candidate analysis |
| ventricular septal defect | 0.517 | — | common-variant locus | no MR -> candidate analysis |
| atherosclerosis | 0.509 | — | common-variant locus | no MR -> candidate analysis |
| substance abuse | 0.501 | — | common-variant locus | no MR -> candidate analysis |
| attention deficit-hyperactivity disorder | 0.501 | — | common-variant locus | no MR -> candidate analysis |
| rheumatoid arthritis | 0.482 | — | common-variant locus | no MR -> candidate analysis |
| eye disorder | 0.456 | — | common-variant locus | no MR -> candidate analysis |
| benign prostatic hyperplasia | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| congenital heart disease | 0.285 | — | established (curated) | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | not available |
| GWAS Catalog | no mapped SNPs |
| ClinVar | no records |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 124 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘TMEM2’.gnomad — No gnomAD constraint data.gwas — No GWAS Catalog SNPs mapped to this gene.clinvar — No ClinVar records.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — No GWAS Catalog associations mapped to this gene.uniprot: https://www.uniprot.org/uniprotkb/Q9UHN6 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000135048/associations — Open Targets data release 26.06