Protein Dossier — TNC (Tenascin)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Body mass index (BMI) |
-0.0121 |
0.00389 |
0.00196 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
-0.0848 |
0.0295 |
0.00408 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertrophic cardiomyopathy (hcm or hocm) |
0.415 |
0.188 |
0.0272 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis |
-0.146 |
0.0663 |
0.0275 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
-0.113 |
0.052 |
0.0303 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: iron deficiency anaemia |
0.103 |
0.0482 |
0.0331 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: osteoarthritis |
0.0266 |
0.0127 |
0.0359 |
Wald ratio |
1 |
cis |
NA |
| Pulse rate |
-0.0137 |
0.00687 |
0.0459 |
Wald ratio |
1 |
cis |
NA |
| Fracture resulting from simple fall |
-0.0197 |
0.0105 |
0.0593 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip] |
0.0577 |
0.0306 |
0.0594 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R04 Haemorrhage from respiratory passages |
-0.113 |
0.0608 |
0.0627 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: L03 Cellulitis |
-0.0873 |
0.0474 |
0.0655 |
Wald ratio |
1 |
cis |
NA |
| …and 55 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4155_3_2 |
Tenascin |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
106 association rows across 65 traits (94 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Tenascin levels |
4e-1960 |
rs1138545 |
11 |
GCST90249798 |
no MR -> candidate analysis |
| Tenascin (analyte X4155.3) levels |
3e-910 |
rs1138545 |
1 |
GCST90425965 |
no MR -> candidate analysis |
| Chymotrypsin-like elastase family member 1 levels |
3e-579 |
rs1138545 |
3 |
GCST90247434 |
no MR -> candidate analysis |
| Prolargin levels (PRELP.5675.6.3) |
2e-489 |
rs1138545 |
2 |
GCST90242391 |
no MR -> candidate analysis |
| Tenascin (analyte X5675.6) levels |
2e-388 |
rs1138545 |
1 |
GCST90426445 |
no MR -> candidate analysis |
| Blood protein levels |
2e-333 |
rs72758637 |
6 |
GCST006585 |
no MR -> candidate analysis |
| Serum levels of protein TNC |
4e-299 |
rs7021589 |
2 |
GCST90088611 |
no MR -> candidate analysis |
| Serum levels of protein CETP |
4e-294 |
rs7029844 |
1 |
GCST90089679 |
no MR -> candidate analysis |
| Serum levels of protein CELA1 |
1e-258 |
rs7029844 |
1 |
GCST90089284 |
no MR -> candidate analysis |
| Circulating TNC levels |
3e-213 |
rs34810955 |
2 |
GCST90860463 |
no MR -> candidate analysis |
| Tenascin (analyte X7131.207) levels |
2e-193 |
rs1138545 |
1 |
GCST90426927 |
no MR -> candidate analysis |
| Height |
2e-176 |
rs1250023 |
7 |
GCST90245848 |
no MR -> candidate analysis |
| …and 53 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1002 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| autosomal dominant nonsyndromic hearing loss |
0.787 |
— |
established (curated) |
no MR -> candidate analysis |
| deafness |
0.832 |
— |
established (curated) |
no MR -> candidate analysis |
| osteoarthritis, hip |
0.846 |
— |
common-variant locus |
no MR -> candidate analysis |
| Dupuytren Contracture |
0.723 |
— |
common-variant locus |
no MR -> candidate analysis |
| Abnormality of the skeletal system |
0.713 |
— |
common-variant locus |
no MR -> candidate analysis |
| total hip arthroplasty |
0.709 |
— |
common-variant locus |
no MR -> candidate analysis |
| medical procedure |
0.635 |
— |
common-variant locus |
no MR -> candidate analysis |
| osteoarthritis, knee |
0.631 |
— |
common-variant locus |
no MR -> candidate analysis |
| osteoarthritis |
0.593 |
— |
common-variant locus |
MR: beta=0.0266, p=0.0359 (cis) |
| vein disorder |
0.594 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.573 |
— |
common-variant locus |
no MR -> candidate analysis |
| lymphatic system disorder |
0.555 |
— |
common-variant locus |
no MR -> candidate analysis |
| Varicose veins |
0.553 |
— |
common-variant locus |
MR: beta=-0.0404, p=0.153 (cis) |
| asthma |
0.499 |
— |
common-variant locus |
MR: beta=0.0102, p=0.346 (cis) |
| total joint arthroplasty |
0.512 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
4 known modulators (Tenascin) |
| gnomAD constraint |
pLI=3.2e-15, LOEUF=0.631 — LoF-tolerant |
| GWAS Catalog |
128 unique SNPs / 275 rows |
| ClinVar |
691 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1002 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘TNC’ and resolved to ‘Tenascin’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 691 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 65 traits by best p-value, aggregated from 106 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P24821 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000041982/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3712856/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/TNC — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TNC — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TNC%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TNC — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:24:58 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none