Protein Dossier — TNFAIP6 (Tumor necrosis factor-inducible gene 6 protein)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level |
0.279 |
0.0862 |
0.00121 |
Wald ratio |
1 |
cis |
NA |
| Triglycerides |
-0.0277 |
0.00858 |
0.00122 |
Wald ratio |
1 |
cis |
NA |
| Height |
-0.0159 |
0.00529 |
0.0027 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: basal cell carcinoma |
-0.152 |
0.0551 |
0.00568 |
Wald ratio |
1 |
cis |
NA |
| Neuroticism |
0.0146 |
0.00548 |
0.00766 |
Wald ratio |
1 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
-0.0155 |
0.00584 |
0.00814 |
Wald ratio |
1 |
cis |
NA |
| Hirschsprung’s disease |
-0.615 |
0.235 |
0.00897 |
Wald ratio |
1 |
cis |
NA |
| Myocardial infarction |
-0.0473 |
0.0188 |
0.0119 |
Wald ratio |
1 |
cis |
NA |
| Inflammatory bowel disease |
-0.0463 |
0.0191 |
0.0155 |
Wald ratio |
1 |
cis |
NA |
| Juvenile idiopathic arthritis |
-0.24 |
0.101 |
0.0176 |
Wald ratio |
1 |
cis |
NA |
| Ulcerative colitis |
-0.0549 |
0.024 |
0.0223 |
Wald ratio |
1 |
cis |
NA |
| Knee osteoarthritis |
-0.113 |
0.0496 |
0.0227 |
Wald ratio |
1 |
cis |
NA |
| …and 106 more outcomes (see JSON) |
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|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5036_50_1 |
TSG-6 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
42 association rows across 26 traits (38 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Serum levels of protein TNFAIP6 |
1e-228 |
rs2278089 |
2 |
GCST90088890 |
no MR -> candidate analysis |
| Tumor necrosis factor-inducible gene 6 protein levels |
1e-135 |
rs2278089 |
7 |
GCST90249989 |
no MR -> candidate analysis |
| Blood protein levels |
7e-132 |
rs2278089 |
1 |
GCST006585 |
no MR -> candidate analysis |
| NMI protein levels |
4e-49 |
rs61345365 |
6 |
GCST90470056 |
no MR -> candidate analysis |
| Tumor necrosis factor-inducible gene 6 protein levels (TNFAI |
2e-25 |
rs201323554 |
1 |
GCST90243184 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein TNFAIP6 levels |
2e-21 |
rs3771893 |
1 |
GCST90943990 |
no MR -> candidate analysis |
| Estimated glomerular filtration rate (creatinine) |
6e-18 |
rs77964389 |
2 |
GCST90100220 |
no MR -> candidate analysis |
| mean corpuscular volume (MCV, minimum, inv-norm transformed) |
2e-15 |
rs13020769 |
1 |
GCST90479677 |
no MR -> candidate analysis |
| mean corpuscular hemoglobin (MCH, minimum, inv-norm transfor |
1e-14 |
rs3948498 |
1 |
GCST90479674 |
no MR -> candidate analysis |
| Skeletal muscle NMI levels |
3e-14 |
rs12476687 |
1 |
GCST90808044 |
no MR -> candidate analysis |
| mean corpuscular hemoglobin (MCH, mean, inv-norm transformed |
4e-14 |
rs3845843 |
1 |
GCST90479673 |
no MR -> candidate analysis |
| Estimated glomerular filtration rate (creatinine, cystatin c |
5e-14 |
rs10930576 |
1 |
GCST90428446 |
no MR -> candidate analysis |
| …and 14 more traits (see JSON) |
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|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 394 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| cardiac transplant |
0.425 |
— |
common-variant locus |
no MR -> candidate analysis |
| type 2 diabetes mellitus |
0.367 |
— |
common-variant locus |
no MR -> candidate analysis |
| diabetes mellitus |
0.316 |
— |
common-variant locus |
no MR -> candidate analysis |
| pneumoconiosis |
0.182 |
— |
common-variant locus |
no MR -> candidate analysis |
| prostate carcinoma |
0.107 |
— |
common-variant locus |
no MR -> candidate analysis |
| brain cancer |
0.076 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 6 rows above, 6 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1.4e-13, LOEUF=1.41 — LoF-tolerant |
| GWAS Catalog |
55 unique SNPs / 98 rows |
| ClinVar |
73 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 394 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘TNFAIP6’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 73 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 26 traits by best p-value, aggregated from 42 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P98066 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000123610/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/TNFAIP6 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TNFAIP6 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TNFAIP6%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TNFAIP6 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:25:10 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none