MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: joint disorder | 0.521 | 0.16 | 0.00109 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: high cholesterol | -0.183 | 0.0582 | 0.00163 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertension | -0.0873 | 0.0332 | 0.00866 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K40 Inguinal hernia | -0.468 | 0.181 | 0.00985 | Wald ratio | 1 | cis | NA |
| Hirschsprung’s disease | -2.36 | 0.93 | 0.0112 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K60 Fissure and fistula of anal and rectal regions | 0.439 | 0.177 | 0.0131 | Wald ratio | 1 | cis | NA |
| Low grade serous ovarian cancer | -0.847 | 0.372 | 0.0227 | Wald ratio | 1 | cis | NA |
| Sodium in urine | -0.0379 | 0.0176 | 0.0308 | Wald ratio | 1 | cis | NA |
| Weight | -0.0321 | 0.0158 | 0.0418 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.0352 | 0.0178 | 0.0485 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | -0.355 | 0.185 | 0.0555 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level | 0.536 | 0.288 | 0.0629 | Wald ratio | 1 | cis | NA |
| …and 48 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
95 association rows across 70 traits (85 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating TNFRSF10B levels | 6e-794 | rs7841989 | 3 | GCST90859758 | no MR -> candidate analysis |
| Circulating TNFRSF10C levels | 6e-588 | rs149683200 | 2 | GCST90859942 | no MR -> candidate analysis |
| TNF-related apoptosis-inducing ligand receptor 2 levels | 1e-172 | rs2293400 | 4 | GCST90012021 | no MR -> candidate analysis |
| TNFRSF10B protein levels | 1e-130 | rs35974498 | 7 | GCST90470900 | no MR -> candidate analysis |
| Cerebrospinal fluid protein TNFRSF10B levels | 4e-90 | rs4871844 | 1 | GCST90943992 | no MR -> candidate analysis |
| Tumor necrosis factor receptor superfamily member 10B levels | 1e-85 | rs4871844 | 1 | GCST90427023 | no MR -> candidate analysis |
| Circulating TNFSF10 levels (id: OID00488_OID20611) | 2e-22 | rs149683200 | 3 | GCST90859847 | no MR -> candidate analysis |
| monocyte (fraction, mean, inv-norm transformed) | 2e-21 | rs4871844 | 2 | GCST90475511 | no MR -> candidate analysis |
| Circulating TNFSF10 levels (id: OID00672_OID20611) | 2e-21 | rs149683200 | 3 | GCST90860016 | no MR -> candidate analysis |
| Aspartate aminotransferase levels (UKB data field 30650) | 4e-21 | rs4871844 | 1 | GCST90468063 | no MR -> candidate analysis |
| Cerebrospinal fluid protein TNFRSF10C levels | 1e-20 | rs143033493 | 1 | GCST90944917 | no MR -> candidate analysis |
| TNFRSF10A protein levels | 3e-20 | rs56108503 | 2 | GCST90470899 | no MR -> candidate analysis |
| …and 58 more traits (see JSON) |
Top diseases by Open Targets association (of 534 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| basal cell carcinoma | 0.762 | — | common-variant locus | MR: beta=-0.987, p=0.394 (cis) |
| head and neck squamous cell carcinoma | 0.657 | — | established (curated) | no MR -> candidate analysis |
| Iron deficiency anemia | 0.637 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.636 | — | common-variant locus | no MR -> candidate analysis |
| renal carcinoma | 0.536 | — | common-variant locus | no MR -> candidate analysis |
| clear cell renal carcinoma | 0.401 | — | established (curated) | no MR -> candidate analysis |
| vascular disorder | 0.476 | — | common-variant locus | no MR -> candidate analysis |
| intestinal disorder | 0.476 | — | common-variant locus | no MR -> candidate analysis |
| prostate carcinoma | 0.418 | — | common-variant locus | no MR -> candidate analysis |
| non-melanoma skin carcinoma | 0.412 | — | common-variant locus | no MR -> candidate analysis |
| skin cancer | 0.307 | — | common-variant locus | no MR -> candidate analysis |
| bipolar disorder | 0.291 | — | common-variant locus | no MR -> candidate analysis |
| jaw disease | 0.291 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.287 | — | common-variant locus | no MR -> candidate analysis |
| ovarian dysfunction | 0.238 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 7 known modulators (Tumor necrosis factor receptor superfamily member 10B) |
| gnomAD constraint | pLI=8.5e-11, LOEUF=1.12 — LoF-tolerant |
| GWAS Catalog | 100 unique SNPs / 200 rows |
| ClinVar | 188 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 534 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘TNFRSF10B’ and resolved to ‘Tumor necrosis factor receptor superfamily member 10B’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 188 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 70 traits by best p-value, aggregated from 95 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O14763 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000120889/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1075153/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/TNFRSF10B — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TNFRSF10B — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TNFRSF10B%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TNFRSF10B — GWAS Catalog search API (live; release not exposed)