Protein Dossier — TNFRSF19 (Tumor necrosis factor receptor superfamily member 19)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Cancer code self-reported: small intestine or small bowel cancer |
1.05 |
0.287 |
2.56e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis |
0.195 |
0.0534 |
2.61e-04 |
Wald ratio |
1 |
cis |
NA |
| Heel bone mineral density (BMD) T-score automated |
-0.0681 |
0.0203 |
8.22e-04 |
Wald ratio |
1 |
cis |
NA |
| Serum cystatin C (eGFRcys) |
0.0355 |
0.012 |
0.00318 |
Wald ratio |
1 |
cis |
NA |
| Nucleus accumbens volume |
-20.8 |
7.13 |
0.0035 |
Wald ratio |
1 |
cis |
NA |
| Chronic kidney disease |
-0.271 |
0.102 |
0.00812 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
-0.478 |
0.184 |
0.00934 |
Wald ratio |
1 |
cis |
NA |
| Age at menopause |
-0.301 |
0.12 |
0.0124 |
Wald ratio |
1 |
cis |
NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
-0.1 |
0.0404 |
0.0132 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
0.097 |
0.04 |
0.0153 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Wrist |
0.218 |
0.0911 |
0.0168 |
Wald ratio |
1 |
cis |
NA |
| Major depressive disorder |
0.323 |
0.139 |
0.0205 |
Wald ratio |
1 |
cis |
NA |
| …and 73 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5131_15_3 |
TAJ |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
51 association rows across 28 traits (39 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating TNFRSF19 levels |
9e-324 |
rs61947047 |
8 |
GCST90860060 |
no MR -> candidate analysis |
| TNFRSF19 protein levels |
1e-293 |
rs4770465 |
7 |
GCST90470909 |
no MR -> candidate analysis |
| JAM2/TNFRSF19 protein level ratio |
2e-261 |
rs11616958 |
1 |
GCST90315241 |
no MR -> candidate analysis |
| TGFBR2/TNFRSF19 protein level ratio |
3e-253 |
rs11616958 |
1 |
GCST90315917 |
no MR -> candidate analysis |
| CLMP/TNFRSF19 protein level ratio |
1e-247 |
rs11616958 |
1 |
GCST90314136 |
no MR -> candidate analysis |
| ACVRL1/TNFRSF19 protein level ratio |
2e-222 |
rs11616958 |
1 |
GCST90313159 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein TNFRSF19 levels |
3e-23 |
rs9553003 |
1 |
GCST90943994 |
no MR -> candidate analysis |
| Height |
4e-23 |
rs1928117 |
2 |
GCST90245848 |
MR: beta=-0.0139, p=0.472 (cis) |
| Tumor necrosis factor receptor superfamily member 19 levels |
2e-22 |
rs754106586 |
3 |
GCST90249837 |
no MR -> candidate analysis |
| Estimated bone mineral density |
7e-19 |
rs7337936 |
3 |
GCST90726625 |
no MR -> candidate analysis |
| Heel bone mineral density |
9e-19 |
rs7987593 |
4 |
GCST007066 |
MR: beta=-0.0681, p=8.22e-04 (cis) |
| Serum levels of protein TNFRSF19 |
4e-15 |
rs3814787 |
1 |
GCST90088947 |
no MR -> candidate analysis |
| …and 16 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 145 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| nasopharyngeal neoplasm |
0.596 |
— |
common-variant locus |
no MR -> candidate analysis |
| bone remodeling disease |
0.511 |
— |
common-variant locus |
no MR -> candidate analysis |
| male infertility |
0.482 |
— |
common-variant locus |
no MR -> candidate analysis |
| cutaneous lupus erythematosus |
0.465 |
— |
common-variant locus |
no MR -> candidate analysis |
| stroke disorder |
0.353 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.353 |
— |
common-variant locus |
no MR -> candidate analysis |
| lung carcinoma |
0.258 |
— |
common-variant locus |
no MR -> candidate analysis |
| Parkinson disease |
0.091 |
— |
common-variant locus |
no MR -> candidate analysis |
| cutaneous melanoma |
0.062 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 9 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=2.4e-05, LOEUF=0.803 — LoF-tolerant |
| GWAS Catalog |
50 unique SNPs / 100 rows |
| ClinVar |
178 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 145 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘TNFRSF19’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 178 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 28 traits by best p-value, aggregated from 51 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q9NS68 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000127863/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/TNFRSF19 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TNFRSF19 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TNFRSF19%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TNFRSF19 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:26:15 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none