Protein Dossier — TNFRSF6B (Tumor necrosis factor receptor superfamily member 6B)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Invasive mucinous ovarian cancer |
-0.731 |
0.267 |
0.00625 |
Wald ratio |
1 |
cis |
NA |
| ER-negative Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
-0.123 |
0.0763 |
0.107 |
Wald ratio |
1 |
cis |
NA |
| Birth weight |
-0.0402 |
0.033 |
0.224 |
Wald ratio |
1 |
cis |
NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) |
-0.0446 |
0.0415 |
0.282 |
Wald ratio |
1 |
cis |
NA |
| Endometrioid ovarian cancer |
0.149 |
0.185 |
0.421 |
Wald ratio |
1 |
cis |
NA |
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5070_76_3 |
DcR3 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
183 association rows across 84 traits (170 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Telomere length (principal component 1) |
1e-300 |
rs35640778 |
9 |
GCST90435144 |
no MR -> candidate analysis |
| Circulating TNFRSF6B levels |
2e-199 |
rs118149249 |
3 |
GCST90860007 |
no MR -> candidate analysis |
| Leukocyte telomere length |
3e-144 |
rs35640778 |
9 |
GCST90709782 |
no MR -> candidate analysis |
| Atopic dermatitis |
5e-109 |
rs6062486 |
17 |
GCST90244787 |
no MR -> candidate analysis |
| TNFRSF6B protein levels |
4e-59 |
rs115610405 |
5 |
GCST90470914 |
no MR -> candidate analysis |
| Glioblastoma |
4e-46 |
rs2297440 |
4 |
GCST004349 |
no MR -> candidate analysis |
| Inflammatory bowel disease |
2e-44 |
rs6062496 |
4 |
GCST90292538 |
no MR -> candidate analysis |
| Glioma |
2e-42 |
rs2297440 |
8 |
GCST004347 |
no MR -> candidate analysis |
| Telomere length |
3e-33 |
rs41309367 |
8 |
GCST90103979 |
no MR -> candidate analysis |
| Chronic inflammatory diseases (ankylosing spondylitis, Crohn |
2e-30 |
rs6062496 |
1 |
GCST005537 |
no MR -> candidate analysis |
| Ulcerative colitis |
4e-26 |
rs6062496 |
3 |
GCST90446794 |
no MR -> candidate analysis |
| Prostate cancer |
7e-26 |
rs77552606 |
7 |
GCST90274713 |
no MR -> candidate analysis |
| …and 72 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 327 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Wheezing |
0.66 |
— |
common-variant locus |
no MR -> candidate analysis |
| prostate carcinoma |
0.624 |
— |
common-variant locus |
no MR -> candidate analysis |
| atopic eczema |
0.64 |
— |
common-variant locus |
no MR -> candidate analysis |
| idiopathic pulmonary fibrosis |
0.63 |
— |
common-variant locus |
no MR -> candidate analysis |
| Crohn disease |
0.513 |
— |
common-variant locus |
no MR -> candidate analysis |
| lower respiratory tract disorder |
0.495 |
— |
common-variant locus |
no MR -> candidate analysis |
| Abnormality of the skeletal system |
0.483 |
— |
common-variant locus |
no MR -> candidate analysis |
| dermatitis |
0.464 |
— |
common-variant locus |
no MR -> candidate analysis |
| metabolic syndrome |
0.454 |
— |
common-variant locus |
no MR -> candidate analysis |
| ulcerative colitis |
0.433 |
— |
common-variant locus |
no MR -> candidate analysis |
| inflammatory bowel disease |
0.43 |
— |
common-variant locus |
no MR -> candidate analysis |
| type 2 diabetes mellitus |
0.417 |
— |
common-variant locus |
no MR -> candidate analysis |
| respiratory system disorder |
0.366 |
— |
common-variant locus |
no MR -> candidate analysis |
| actinic keratosis |
0.359 |
— |
common-variant locus |
no MR -> candidate analysis |
| asthma |
0.313 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=4.3e-10, LOEUF=1.82 — LoF-tolerant |
| GWAS Catalog |
178 unique SNPs / 492 rows |
| ClinVar |
561 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 327 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘TNFRSF6B’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 561 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 84 traits by best p-value, aggregated from 183 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/O95407 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000243509/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/TNFRSF6B — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TNFRSF6B — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TNFRSF6B%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TNFRSF6B — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T05:26:49 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none