MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Sodium in urine | -0.0319 | 0.00986 | 0.00121 | Wald ratio | 1 | cis | NA |
| Creatinine (enzymatic) in urine | -0.0309 | 0.00959 | 0.00129 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | 0.0295 | 0.01 | 0.00318 | Wald ratio | 1 | cis | NA |
| HbA1C | -0.0424 | 0.0144 | 0.00325 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | -0.0221 | 0.00822 | 0.00717 | Wald ratio | 1 | cis | NA |
| Rheumatoid arthritis | -0.168 | 0.0657 | 0.0105 | Wald ratio | 1 | cis | NA |
| Fasting glucose | -0.0317 | 0.0132 | 0.0161 | Wald ratio | 1 | cis | NA |
| Urate | 0.0535 | 0.0226 | 0.0181 | Wald ratio | 1 | cis | NA |
| Potassium in urine | -0.0234 | 0.0102 | 0.0211 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux | 0.0999 | 0.0438 | 0.0223 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: uterine fibroids | 0.159 | 0.0694 | 0.0224 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | -0.0188 | 0.00867 | 0.0302 | Wald ratio | 1 | cis | NA |
| …and 77 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
13 association rows across 11 traits (9 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Protein-tyrosine sulfotransferase 2 levels | 4e-80 | rs6005067 | 1 | GCST90249186 | no MR -> candidate analysis |
| Protein-tyrosine sulfotransferase 2 levels (TPST2.8024.64.3) | 6e-23 | rs2283824 | 1 | GCST90242535 | no MR -> candidate analysis |
| Serum levels of protein TPST2 | 1e-15 | rs4275 | 1 | GCST90089994 | no MR -> candidate analysis |
| CRYBB1 protein levels | 4e-15 | rs186949153 | 1 | GCST90468874 | no MR -> candidate analysis |
| Hypotony of eye (PheCode 360.3) | 1e-12 | rs535337559 | 1 | GCST90480038 | no MR -> candidate analysis |
| Body mass index | 8e-12 | rs2283824 | 2 | GCST90662912 | MR: beta=0.0295, p=0.00318 (cis) |
| Episodic memory (pairs-matching) | 2e-9 | rs1007876 | 1 | GCST90011295 | no MR -> candidate analysis |
| Personality traits or cognitive traits (multivariate analysi | 4e-8 | rs12169970 | 1 | GCST90270074 | no MR -> candidate analysis |
| Gut microbial network clusters (Cyan (at 3 months) x Homesmo | 2e-7 | rs4822735 | 1 | GCST90569280 | no MR -> candidate analysis |
| Developmental language disorder (linguistic errors) | 2e-6 | rs5761618 | 1 | GCST003397 | no MR -> candidate analysis |
| Anti-saccade response | 4e-6 | rs2283831 | 2 | GCST005025 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 302 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| diabetes mellitus | 0.456 | — | common-variant locus | no MR -> candidate analysis |
| ocular hypotension | 0.451 | — | common-variant locus | no MR -> candidate analysis |
| episodic memory | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| arthropathy | 0.389 | — | common-variant locus | no MR -> candidate analysis |
| pathological myopia | 0.389 | — | common-variant locus | no MR -> candidate analysis |
| type 1 diabetes mellitus | 0.389 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.114 | — | common-variant locus | no MR -> candidate analysis |
| skin cancer | 0.107 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.1 | — | common-variant locus | no MR -> candidate analysis |
| bacterial arthritis | 0.097 | — | common-variant locus | no MR -> candidate analysis |
| adverse effect | 0.094 | — | common-variant locus | no MR -> candidate analysis |
| mathematical ability | 0.084 | — | common-variant locus | no MR -> candidate analysis |
Of the 12 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Protein-tyrosine sulfotransferase 2) |
| gnomAD constraint | pLI=0.0016, LOEUF=0.876 — LoF-tolerant |
| GWAS Catalog | 32 unique SNPs / 63 rows |
| ClinVar | 85 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 302 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘TPST2’ and resolved to ‘Protein-tyrosine sulfotransferase 2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 85 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 11 of 11 traits by best p-value, aggregated from 13 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O60704 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000128294/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3178/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/TPST2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/TPST2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=TPST2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/TPST2 — GWAS Catalog search API (live; release not exposed)